• Gene id: 3620

Gene Summary

• Gene Symbol: IDO1   Gene   UCSC   Ensembl
• Aliases: IDO, IDO-1, INDO
• Gene name: indoleamine 2,3-dioxygenase 1
• Alternate names: indoleamine 2,3-dioxygenase 1, indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, indoleamine-pyrrole 2,3-dioxygenase,
• Gene location: 8p11.21 (39913890: 39928789)     Exons: 10     NC_000008.11
• Gene summary(Entrez): This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5
• OMIM: 147435

Protein Summary

• Protein general information: P14902  
  • Name: Indoleamine 2,3 dioxygenase 1 (IDO 1) (EC 1.13.11.52) (Indoleamine pyrrole 2,3 dioxygenase)
  • Length: 403  
  • Mass: 45326
  • Tissue specificity: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as
• Sequence:

  MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKS
  QRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDV
  LFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKA
  FFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
  PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLE
  AKGTGGTDLMNFLKTVRSTTEKSLLKEG

• Structural information:
  • Interpro: IPR000898  IPR037217  
  • Prosite: PS00876 PS00877
  • PDB: 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6MQ6 6O3I 6PU7 6PZ1 6R63
  • PDBsum: 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6MQ6 6O3I 6PU7 6PZ1 6R63
  • STRING: ENSP00000430950
• Other Databases: GeneCards:  IDO1  Malacards:  IDO1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0004833	tryptophan 2,3-dioxygenase activity	IBA	molecular function
GO:0019441	tryptophan catabolic process to kynurenine	IBA	biological process
GO:0033754	indoleamine 2,3-dioxygenase activity	IBA	molecular function
GO:0034354	'de novo' NAD biosynthetic process from tryptophan	IBA	biological process
GO:0019441	tryptophan catabolic process to kynurenine	IEA	biological process
GO:0020037	heme binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006569	tryptophan catabolic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051213	dioxygenase activity	IEA	molecular function
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006569	tryptophan catabolic process	TAS	biological process
GO:0007565	female pregnancy	TAS	biological process
GO:0033754	indoleamine 2,3-dioxygenase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006569	tryptophan catabolic process	TAS	biological process
GO:0070233	negative regulation of T cell apoptotic process	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0033555	multicellular organismal response to stress	IEA	biological process
GO:0032735	positive regulation of interleukin-12 production	IEA	biological process
GO:0032693	negative regulation of interleukin-10 production	IEA	biological process
GO:0032496	response to lipopolysaccharide	IEA	biological process
GO:0032421	stereocilium bundle	IEA	cellular component
GO:0030485	smooth muscle contractile fiber	IEA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0002830	positive regulation of type 2 immune response	IEA	biological process
GO:0002678	positive regulation of chronic inflammatory response	IEA	biological process
GO:0002534	cytokine production involved in inflammatory response	IEA	biological process
GO:0042130	negative regulation of T cell proliferation	IEA	biological process
GO:0036269	swimming behavior	IEA	biological process
GO:0034276	kynurenic acid biosynthetic process	IEA	biological process
GO:0019441	tryptophan catabolic process to kynurenine	IEA	biological process
GO:0004833	tryptophan 2,3-dioxygenase activity	IEA	molecular function
GO:0002666	positive regulation of T cell tolerance induction	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0022900	electron transport chain	IEA	biological process
GO:0019441	tryptophan catabolic process to kynurenine	IEA	biological process
GO:0033754	indoleamine 2,3-dioxygenase activity	IMP	molecular function
GO:0046006	regulation of activated T cell proliferation	IMP	NOT|biological process
GO:0070234	positive regulation of T cell apoptotic process	IMP	biological process
GO:0009055	electron transfer activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00380	Tryptophan metabolism
hsa05143	African trypanosomiasis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)