• Gene id: 3612

Gene Summary

• Gene Symbol: IMPA1   Gene   UCSC   Ensembl
• Aliases: IMP, IMPA, MRT59
• Gene name: inositol monophosphatase 1
• Alternate names: inositol monophosphatase 1, D-galactose 1-phosphate phosphatase, IMP 1, IMPase 1, inositol(myo)-1(or 4)-monophosphatase 1, inositol-1(or 4)-monophosphatase 1, lithium-sensitive myo-inositol monophosphatase A1, myo-inositol monophosphatase 1, testicular tissue pro,
• Gene location: 8q21.13 (81686353: 81656913)     Exons: 10     NC_000008.11
• Gene summary(Entrez): This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second
• OMIM: 602064

Protein Summary

• Protein general information: P29218  
  • Name: Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D galactose 1 phosphate phosphatase) (EC 3.1.3.94) (Inositol 1(or 4) monophosphatase 1) (Lithium sensitive myo inositol monophosphatase A1)
  • Length: 277  
  • Mass: 30189
• Sequence:

  MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAA
  GEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQ
  QEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAG
  IIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED

• Structural information:
  • Interpro: IPR033942  IPR020583  IPR020552  IPR000760  IPR020550  
  • Prosite: PS00629 PS00630
  • CDD: cd01639
  • PDB: 1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4 6GIU 6GJ0
  • PDBsum: 1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4 6GIU 6GJ0
  • STRING: ENSP00000408526
• Other Databases: GeneCards:  IMPA1  Malacards:  IMPA1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046855	inositol phosphate dephosphorylation	IBA	biological process
GO:0007165	signal transduction	IBA	biological process
GO:0008934	inositol monophosphate 1-phosphatase activity	IBA	molecular function
GO:0006020	inositol metabolic process	IBA	biological process
GO:0046855	inositol phosphate dephosphorylation	IDA	biological process
GO:0052834	inositol monophosphate phosphatase activity	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0030145	manganese ion binding	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0031403	lithium ion binding	IDA	molecular function
GO:0046855	inositol phosphate dephosphorylation	IEA	biological process
GO:0008934	inositol monophosphate 1-phosphatase activity	IEA	molecular function
GO:0046854	phosphatidylinositol phosphorylation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0052832	inositol monophosphate 3-phosphatase activity	IEA	molecular function
GO:0052834	inositol monophosphate phosphatase activity	IEA	molecular function
GO:0008934	inositol monophosphate 1-phosphatase activity	IEA	molecular function
GO:0052833	inositol monophosphate 4-phosphatase activity	IEA	molecular function
GO:0046855	inositol phosphate dephosphorylation	IDA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0008934	inositol monophosphate 1-phosphatase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0043647	inositol phosphate metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006021	inositol biosynthetic process	IEA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0007165	signal transduction	IMP	biological process
GO:0008934	inositol monophosphate 1-phosphatase activity	IMP	molecular function
GO:0006796	phosphate-containing compound metabolic process	IMP	biological process
GO:0006661	phosphatidylinositol biosynthetic process	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04070	Phosphatidylinositol signaling system
hsa00562	Inositol phosphate metabolism

Diseases

Associated diseases	References
Autosomal recessive mental retardation	KEGG:H00768
Autosomal recessive mental retardation	KEGG:H00768
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq