• Gene id: 3596

Gene Summary

• Gene Symbol: IL13   Gene   UCSC   Ensembl
• Aliases: IL-13, P600
• Gene name: interleukin 13
• Alternate names: interleukin-13,
• Gene location: 5q31.1 (133418171: 133406057)     Exons: 11     NC_000009.12
• Gene summary(Entrez): This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype swit
• OMIM: 147683

Protein Summary

• Protein general information: P35225  
  • Name: Interleukin 13 (IL 13)
  • Length: 146  
  • Mass: 15816
• Sequence:

  MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAG
  MYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

• Structural information:
  • Interpro: IPR009079  IPR020470  IPR001325  IPR018096  
  • Prosite: PS00838
  • PDB: 1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
  • PDBsum: 1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
  • DIP: 3224
  • STRING: ENSP00000304915
• Other Databases: GeneCards:  IL13  Malacards:  IL13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:2001181	positive regulation of interleukin-10 secretion	IGI	biological process
GO:0010628	positive regulation of gene expression	IGI	biological process
GO:0010628	positive regulation of gene expression	ISS	biological process
GO:0042116	macrophage activation	IGI	biological process
GO:0050728	negative regulation of inflammatory response	IGI	biological process
GO:0005126	cytokine receptor binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0006955	immune response	IEA	biological process
GO:0005125	cytokine activity	IEA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0006954	inflammatory response	TAS	biological process
GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	biological process
GO:1903660	negative regulation of complement-dependent cytotoxicity	IMP	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0071260	cellular response to mechanical stimulus	IEA	biological process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	IEA	biological process
GO:0050714	positive regulation of protein secretion	IEA	biological process
GO:0048661	positive regulation of smooth muscle cell proliferation	IEA	biological process
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IEA	biological process
GO:0035094	response to nicotine	IEA	biological process
GO:0032723	positive regulation of connective tissue growth factor production	IEA	biological process
GO:0032496	response to lipopolysaccharide	IEA	biological process
GO:0030890	positive regulation of B cell proliferation	IEA	biological process
GO:0001774	microglial cell activation	IEA	biological process
GO:0120162	positive regulation of cold-induced thermogenesis	IEA	biological process
GO:0071345	cellular response to cytokine stimulus	IEA	biological process
GO:0043032	positive regulation of macrophage activation	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:2000231	positive regulation of pancreatic stellate cell proliferation	IEA	biological process
GO:1901215	negative regulation of neuron death	IEA	biological process
GO:0071635	negative regulation of transforming growth factor beta production	IEA	biological process
GO:0045471	response to ethanol	IEA	biological process
GO:0043270	positive regulation of ion transport	IEA	biological process
GO:0033861	negative regulation of NAD(P)H oxidase activity	IEA	biological process
GO:0010628	positive regulation of gene expression	IEA	biological process
GO:0010155	regulation of proton transport	IEA	biological process
GO:0009612	response to mechanical stimulus	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005144	interleukin-13 receptor binding	IEA	molecular function
GO:0002639	positive regulation of immunoglobulin production	IEA	biological process
GO:0043306	positive regulation of mast cell degranulation	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0002639	positive regulation of immunoglobulin production	IEA	biological process
GO:0005576	extracellular region	IDA	cellular component
GO:1901247	negative regulation of lung ciliated cell differentiation	NAS	biological process
GO:1901251	positive regulation of lung goblet cell differentiation	NAS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0120162	positive regulation of cold-induced thermogenesis	ISS	biological process
GO:0005615	extracellular space	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	JAK-STAT signaling pathway
hsa04658	Th1 and Th2 cell differentiation
hsa04657	IL-17 signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa05321	Inflammatory bowel disease
hsa05310	Asthma

Diseases

Associated diseases	References
Allergic rhinitis	KEGG:H01360
Atopic dermatitis	KEGG:H01358
Asthma	KEGG:H00079
Allergic rhinitis	KEGG:H01360
Atopic dermatitis	KEGG:H01358
Asthma	KEGG:H00079
Non-alcoholic fatty liver disease	PMID:18802068
Pulmonary edema	PMID:15635619
Onchocerciasis	PMID:22805723
Vitiligo	PMID:23680073
Graves' disease	PMID:15483090
Graves' disease	PMID:21235536
Sjogren's syndrome	PMID:12051401
Cystic fibrosis	PMID:15463872
Diffuse scleroderma	PMID:16832637
pancreatic cancer	PMID:18758789
pancreatic cancer	PMID:12808442
Multiple sclerosis	PMID:21677024
Dermatitis	PMID:23171465
Bronchiolitis obliterans	PMID:17182591
Asthma	PMID:11758895
Asthma	PMID:17006604
invasive ductal carcinoma	PMID:22135852
Chronic obstructive pulmonary disease	PMID:19796199
Atopic dermatitis	PMID:16672002
Atopic dermatitis	PMID:10887320
Purpura	PMID:16166103
Mastocytosis	PMID:19178408
Pulmonary fibrosis	PMID:19654941
ovarian carcinoma	PMID:14984938
systemic scleroderma	PMID:9034992
Pulmonary hypertension	PMID:19799786
Rheumatoid arthritis	PMID:12051401
Scleroderma	PMID:12920362
Lung disease	PMID:20716936
Psoriasis	PMID:23617596
Psoriatic arthritis	PMID:21349879
Psoriatic arthritis	PMID:19554022
Systemic lupus erythematosus	PMID:12051401
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R