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Gene id 3576
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol CXCL8   Gene   UCSC   Ensembl
Aliases GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1
Gene name C-X-C motif chemokine ligand 8
Alternate names interleukin-8, T-cell chemotactic factor, alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protei,
Gene location 4q13.3 (73740505: 73743715)     Exons: 4     NC_000004.12
Gene summary(Entrez) The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to
OMIM 146930

Protein Summary
Protein general information P10145  

Name: Interleukin 8 (IL 8) (C X C motif chemokine 8) (Chemokine (C X C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP 1) (Monocyte derived neutrophil chemotactic factor) (MDNCF) (Monocyte derived neutrophil activating peptide) (MONAP) (Ne

Length: 99  Mass: 11,098

Sequence MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRE
LCLDPKENWVQRVVEKFLKRAENS
Structural information
Interpro:  IPR001089  IPR018048  IPR001811  IPR033899  IPR028469  
IPR036048  
Prosite:   PS00471
CDD:   cd00273

PDB:  		 1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ
PDBsum:   1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ

DIP:  
3778
STRING:   ENSP00000306512
Other Databases GeneCards:  CXCL8  Malacards:  CXCL8

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0001525 angiogenesis
 TAS biological process
GO:0002237 response to molecule of b
acterial origin
 IDA biological process
GO:0005153 interleukin-8 receptor bi
nding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005615 extracellular space
 IEA cellular component
GO:0005622 intracellular
 IEA cellular component
GO:0006928 movement of cell or subce
llular component
 TAS biological process
GO:0006935 chemotaxis
 TAS biological process
GO:0006954 inflammatory response
 TAS biological process
GO:0006955 immune response
 IBA biological process
GO:0007050 cell cycle arrest
 IDA biological process
GO:0007165 signal transduction
 TAS biological process
GO:0007186 G-protein coupled recepto
r signaling pathway
 TAS biological process
GO:0008009 chemokine activity
 TAS molecular function
GO:0008285 negative regulation of ce
ll proliferation
 TAS biological process
GO:0019722 calcium-mediated signalin
g
 TAS biological process
GO:0030155 regulation of cell adhesi
on
 IDA biological process
GO:0030593 neutrophil chemotaxis
 IGI biological process
GO:0031623 receptor internalization
 IDA biological process
GO:0034976 response to endoplasmic r
eticulum stress
 IDA biological process
GO:0035556 intracellular signal tran
sduction
 IDA biological process
GO:0036499 PERK-mediated unfolded pr
otein response
 TAS biological process
GO:0042119 neutrophil activation
 TAS biological process
GO:0044344 cellular response to fibr
oblast growth factor stim
ulus
 IEP biological process
GO:0045091 regulation of single stra
nded viral RNA replicatio
n via double stranded DNA
intermediate
 IDA biological process
GO:0045744 negative regulation of G-
protein coupled receptor
protein signaling pathway
 IDA biological process
GO:0045766 positive regulation of an
giogenesis
 IDA biological process
GO:0048566 embryonic digestive tract
development
 IEP biological process
GO:0050930 induction of positive che
motaxis
 IGI biological process
GO:0070098 chemokine-mediated signal
ing pathway
 IBA biological process
GO:0071222 cellular response to lipo
polysaccharide
 IDA biological process
GO:0071347 cellular response to inte
rleukin-1
 IEP biological process
GO:0071356 cellular response to tumo
r necrosis factor
 IEP biological process
GO:0090023 positive regulation of ne
utrophil chemotaxis
 TAS biological process
GO:0001525 angiogenesis
 TAS biological process
GO:0002237 response to molecule of b
acterial origin
 IDA biological process
GO:0005125 cytokine activity
 IEA molecular function
GO:0005153 interleukin-8 receptor bi
nding
 IEA molecular function
GO:0005153 interleukin-8 receptor bi
nding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005576 extracellular region
 IEA cellular component
GO:0005576 extracellular region
 IEA cellular component
GO:0005576 extracellular region
 IEA cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005615 extracellular space
 IEA cellular component
GO:0005615 extracellular space
 TAS cellular component
GO:0005622 intracellular
 IEA cellular component
GO:0006928 movement of cell or subce
llular component
 TAS biological process
GO:0006935 chemotaxis
 IEA biological process
GO:0006935 chemotaxis
 TAS biological process
GO:0006954 inflammatory response
 IEA biological process
GO:0006954 inflammatory response
 TAS biological process
GO:0006954 inflammatory response
 TAS biological process
GO:0006955 immune response
 IEA biological process
GO:0006955 immune response
 IBA biological process
GO:0007050 cell cycle arrest
 IDA biological process
GO:0007165 signal transduction
 TAS biological process
GO:0007186 G-protein coupled recepto
r signaling pathway
 TAS biological process
GO:0008009 chemokine activity
 IEA molecular function
GO:0008009 chemokine activity
 TAS molecular function
GO:0008009 chemokine activity
 TAS molecular function
GO:0008285 negative regulation of ce
ll proliferation
 TAS biological process
GO:0019722 calcium-mediated signalin
g
 TAS biological process
GO:0030155 regulation of cell adhesi
on
 IDA biological process
GO:0030593 neutrophil chemotaxis
 IEA biological process
GO:0030593 neutrophil chemotaxis
 IGI biological process
GO:0031623 receptor internalization
 IDA biological process
GO:0034976 response to endoplasmic r
eticulum stress
 IDA biological process
GO:0035556 intracellular signal tran
sduction
 IDA biological process
GO:0036499 PERK-mediated unfolded pr
otein response
 TAS biological process
GO:0042119 neutrophil activation
 IEA biological process
GO:0042119 neutrophil activation
 TAS biological process
GO:0044344 cellular response to fibr
oblast growth factor stim
ulus
 IEP biological process
GO:0045091 regulation of single stra
nded viral RNA replicatio
n via double stranded DNA
intermediate
 IDA biological process
GO:0045744 negative regulation of G-
protein coupled receptor
protein signaling pathway
 IDA biological process
GO:0045766 positive regulation of an
giogenesis
 IDA biological process
GO:0048566 embryonic digestive tract
development
 IEP biological process
GO:0050930 induction of positive che
motaxis
 IGI biological process
GO:0070098 chemokine-mediated signal
ing pathway
 IBA biological process
GO:0071222 cellular response to lipo
polysaccharide
 IDA biological process
GO:0071347 cellular response to inte
rleukin-1
 IEP biological process
GO:0071356 cellular response to tumo
r necrosis factor
 IEP biological process
GO:0090023 positive regulation of ne
utrophil chemotaxis
 TAS biological process
GO:0001525 angiogenesis
 TAS biological process
GO:0002237 response to molecule of b
acterial origin
 IDA biological process
GO:0005153 interleukin-8 receptor bi
nding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005576 extracellular region
 TAS cellular component
GO:0005615 extracellular space
 TAS cellular component
GO:0006928 movement of cell or subce
llular component
 TAS biological process
GO:0006935 chemotaxis
 TAS biological process
GO:0006954 inflammatory response
 TAS biological process
GO:0006954 inflammatory response
 TAS biological process
GO:0006955 immune response
 IBA biological process
GO:0007050 cell cycle arrest
 IDA biological process
GO:0007165 signal transduction
 TAS biological process
GO:0007186 G-protein coupled recepto
r signaling pathway
 TAS biological process
GO:0008009 chemokine activity
 TAS molecular function
GO:0008009 chemokine activity
 TAS molecular function
GO:0008285 negative regulation of ce
ll proliferation
 TAS biological process
GO:0019722 calcium-mediated signalin
g
 TAS biological process
GO:0030155 regulation of cell adhesi
on
 IDA biological process
GO:0030593 neutrophil chemotaxis
 IGI biological process
GO:0031623 receptor internalization
 IDA biological process
GO:0034976 response to endoplasmic r
eticulum stress
 IDA biological process
GO:0035556 intracellular signal tran
sduction
 IDA biological process
GO:0036499 PERK-mediated unfolded pr
otein response
 TAS biological process
GO:0042119 neutrophil activation
 TAS biological process
GO:0044344 cellular response to fibr
oblast growth factor stim
ulus
 IEP biological process
GO:0045091 regulation of single stra
nded viral RNA replicatio
n via double stranded DNA
intermediate
 IDA biological process
GO:0045744 negative regulation of G-
protein coupled receptor
protein signaling pathway
 IDA biological process
GO:0045766 positive regulation of an
giogenesis
 IDA biological process
GO:0048566 embryonic digestive tract
development
 IEP biological process
GO:0050930 induction of positive che
motaxis
 IGI biological process
GO:0070098 chemokine-mediated signal
ing pathway
 IBA biological process
GO:0071222 cellular response to lipo
polysaccharide
 IDA biological process
GO:0071347 cellular response to inte
rleukin-1
 IEP biological process
GO:0071356 cellular response to tumo
r necrosis factor
 IEP biological process
GO:0090023 positive regulation of ne
utrophil chemotaxis
 TAS biological process

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa04072Phospholipase D signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04061Viral protein interaction with cytokine and cytokine receptor
hsa04218Cellular senescence
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04657IL-17 signaling pathway
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05219Bladder cancer
hsa05323Rheumatoid arthritis
hsa04932Non-alcoholic fatty liver disease
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05131Shigellosis
hsa05135Yersinia infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05164Influenza A
hsa05161Hepatitis B
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05146Amoebiasis
hsa05144Malaria
hsa05142Chagas disease

Diseases

Expand All | Collapse All
Associated diseases References
Cancer GAD: 18457043
Cancer (colon) GAD: 18550579
Cancer (colorectal) GAD: 12839942
Cancer (esophageal) GAD: 15598788
Cancer (gastric) GAD: 19013788
Cancer (Hepatocellular) GAD: 12668613
Cancer (laryngeal) GAD: 17356794
Cancer (leiomyoma) GAD: 17222831
Cancer (leukemia) GAD: 19074885
Cancer (lung) GAD: 14604894
Cancer (lymphoma) GAD: 17327408
Cancer (melanoma) GAD: 14675394
Cancer (meningeal) GAD: 20406964
Cancer (myeloma) GAD: 20568250
Cancer (nasopharyngeal) GAD: 17720627
Cancer (non-melanoma skin cancer) GAD: 17307204
Cancer (oral) GAD: 17174061
Cancer (ovarian) GAD: 20628624
Cancer (prostate) GAD: 12067976
Cancer (Squamous cell) GAD: 20133197
Cancer (stomach) GAD: 15579481
Cancer (endometrial) INFBASE: 20074813
Cancer (Adenocarcinoma) GAD: 18542040
Cancer (Biliary tract neoplasms) GAD: 18676870
Cancer (bladder) GAD: 16110031
Cancer (cervical) GAD: 19012493
Cancer (breast) GAD: 15265021
Apoplexy GAD: 17802898
Atherosclerosis GAD: 19347053
Brain ischemia GAD: 18549840
Cardiovascular disease GAD: 18385984
Cystic fibrosis GAD: 17336597
Enterocolitis GAD: 21058913
Graves disease GAD: 16313297
Choroidal neovascularization GAD: 18235016
Macular degeneration GAD: 18310311
Mucocutaneous lymph node syndrome GAD: 21048327
Hodgkin disease GAD: 21061265
Arthritis GAD: 18799095
Asthma GAD: 15356575
Behcet's disease GAD: 15630732
Bullous pemphigoid GAD: 16403098
Ulcerative colitis GAD: 19348790
Multiple sclerosis GAD: 16793206
Psoriasis GAD: 17388919
Systemic lupus erythematosus (SLE) GAD: 12081586
Systemic lupus erythematosus (SLE) GAD: 12081586
Diabetes GAD: 19357773
Osteoarthritis GAD: 15708897
Alzheimer's disease GAD: 15854776
Parkinson disease GAD: 15120188
Cerebral palsy GAD: 18977990
Cirrhosis GAD: 15220553
Chronic renal failure GAD: 21085059
Chorioamnionitis GAD: 20452482
Infertility INFBASE: 8792937
Adenomyosis INFBASE: 16500343
Endometriosis INFBASE: 17706208
Polycystic ovary syndrome (PCOS) INFBASE: 23900753
Poor ovarian response (POR) INFBASE: 25083184
Recurrent implantation failure (RIF) INFBASE: 22201617
Ectopic endometriosis INFBASE: 10087426
Follicular size INFBASE: 19285667
Ovarian endometriosis INFBASE: 15005245
Female infertility INFBASE: 10783347
Ovarian hyperstimulation syndrome (OHSS) INFBASE: 18171700
Unexplained infertility INFBASE: 17688616
Oligoasthenozoospermia MIK: 19239426
Asthenozoospermia MIK: 11839394
Leukocytospermia MIK: 11839394
Sperm autoantibodies MIK: 19239426
Obstructive azoospermia MIK: 19811461
Male subfertility MIK: 19811461
Prostate inflammatory diseases MIK: 21738005
Leukocytospermia MIK: 12749127
Asthenozoospermia MIK: 19239426
Male subfertility MIK: 19811461
Male factor infertility MIK: 21244563
Asthenozoospermia MIK: 19811461
Male factor infertility MIK: 19811461
Oligozoospermia MIK: 11839394
Oligozoospermia MIK: 17341438
Female infertility INFBASE: 25797583
Asthenozoospermia MIK: 17341438
Female infertility INFBASE: 25376627
Endometriosis INFBASE: 8612850
Endometriosis-associated infertility INFBASE: 17688616
Female infertility INFBASE: 17688616
Female infertility INFBASE: 15552530
Fertilizing defects INFBASE: 18228126
Chronic obstructive pulmonary disease (COPD) GAD: 16007706
Dermatitis GAD: 18416756
Connective tissue diseases GAD: 19527514
Atrophy GAD: 18301299
Barrett's esophagus GAD: 18192685
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Asthenozoospermia MIK: 11839394
Oligozoospermia MIK: 11839394
Leukocytospermia MIK: 7789553
Male infertility MIK: 14555327
Sperm autoantibodies MIK: 19239426
Oligoasthenozoospermia MIK: 19239426
Male subfertility MIK: 19811461
Azoospermia MIK: 19811461
Spermatogenic defects MIK: 31037746
Teratozoospermia MIK: 17327269

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21244563 Male Infer
tility
57 (33 controls
, 24 infertile
)
 Male infertility IL-23
IL-6
IL-8 and TNF-? 
 Show abstract
19811461 Male subfe
rtility
73 male partner
s of an inferti
le couple
 Male infertility IL-6
IL-8
IL-10
IL-11
IL-12
 TNF-alpha and IFN-gamma
 Show abstract
20576636 Infertilit
y
96 (male infert
ility, n = 61;
female infertil
ity factors, n
= 35)
 Male infertility, Female infertility
Show abstract
19811461 Subfertile
men
74 male partner
s
 Male infertility IL-6
IL-10
TNF-alpha
IFN-gamma
 Show abstract
17341438 Oligozoosp
ermia, ast
henozoospe
rmia
62 (34 controls
, 28 men with o
ligozoospermia
or asthenozoosp
ermia)
 Male infertility IL-6
IL-8
VEGF
TNFalpha
IL-1beta
TGFbeta1 and G-CSF
 Show abstract
14555327 Male infer
tility

Male infertility Fas
IL-6
IL-8
 Show abstract
19811461 Obstructed
azoosperm
ia, asthen
ospermia
73 male partner
s of an inferti
le couple atten
ding a regional
andrology unit
 
 Male infertility  IL-6
IL-8
IL-10
IL-11
IL-12
TNF-alpha and IFN-gamma
 Show abstract
14555327 Male infer
tility

Male infertility Fas
IL-6 and IL-8
 Show abstract
19239426 Male infer
tility, Sp
erm autoan
tibodies,
oligoasthe
nospermia,
asthenosp
ermia

Male infertility IL-1beta
IL-2
 IL-4
IL-5
IL-6
IL-8
IL-10
IL-12p70 TNF-alpha
and IFN-gamma
 Show abstract
11839394 Asthenozoo
spermia, o
ligozoospe
rmia, leuk
ocytosperm
ia
86 (62 subjects
in the normozo
ospermic group,
24 subjects sh
owing abnormal
sperm parameter
s (azoospermia,
n=5; oligozoos
permia, n=4; as
thenozoospermia
, n=15))
 Male infertility interleukin [IL]-1alpha
IL-2
 IL-4
IL-6
IL-8
tumor necrosis factor-alpha [TNF-alpha]
interferon-gamma
granulocyte colony-stimulating factor [G-CSF]
macrophage CFS [M-CSF]
 Show abstract
12749127 Leukocytos
permia, ma
le inferti
lity
42 (15 normal d
onors, 16 infer
tile men withou
t infection, 11
leukocytosperm
ia)
 Male infertility IL-8
 Show abstract
7789553 Leukocytos
permia

Male infertility Elastase
SOD
IL2
IL-8
 Show abstract
8458511 Male infer
tility, le
ukospermia
58 (34 infertil
e men without l
eukospermia, 10
infertile men
with leukosperm
ia, 14 proven f
ertile men)
 Male infertility IL-8
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
31037746 Spermatoge
nic defect
s
16 (1 control,
15 cases)
 Male infertility GSE6023 analyzed using GEO2R
 Show abstract