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Gene id 3569
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol IL6   Gene   UCSC   Ensembl
Aliases BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Gene name interleukin 6
Alternate names interleukin-6, B-cell differentiation factor, B-cell stimulatory factor 2, CTL differentiation factor, hybridoma growth factor, interferon beta-2, interleukin BSF-2,
Gene location 7p15.3 (22725888: 22732001)     Exons: 6     NC_000007.14
Gene summary(Entrez) This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein
OMIM 147620

Protein Summary

Protein general information P05231  

Name: Interleukin 6 (IL 6) (B cell stimulatory factor 2) (BSF 2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta 2) (IFN beta 2)

Length: 212  Mass: 23,718

Tissue specificity: Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.

Sequence MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKS
NMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVL
IQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Structural information
Interpro:  IPR009079  IPR003574  IPR030474  IPR030473  
Prosite:   PS00254

PDB:  
1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC
PDBsum:   1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC

DIP:  

482

STRING:   ENSP00000258743
Other Databases GeneCards:  IL6  Malacards:  IL6

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04668TNF signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04061Viral protein interaction with cytokine and cytokine receptor
hsa04218Cellular senescence
hsa04640Hematopoietic cell lineage
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04625C-type lectin receptor signaling pathway
hsa04659Th17 cell differentiation
hsa04657IL-17 signaling pathway
hsa04672Intestinal immune network for IgA production
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05323Rheumatoid arthritis
hsa05321Inflammatory bowel disease
hsa05332Graft-versus-host disease
hsa05020Prion diseases
hsa05410Hypertrophic cardiomyopathy
hsa04932Non-alcoholic fatty liver disease
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05135Yersinia infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05152Tuberculosis
hsa05166Human T-cell leukemia virus 1 infection
hsa05162Measles
hsa05164Influenza A
hsa05161Hepatitis B
hsa05168Herpes simplex virus 1 infection
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05169Epstein-Barr virus infection
hsa05146Amoebiasis
hsa05144Malaria
hsa05142Chagas disease
hsa05143African trypanosomiasis
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa01523Antifolate resistance
Associated diseases References
Cancer GAD: 16389181
Cancer (Adenocarcinoma) GAD: 19692203
Cancer (Adenoma) GAD: 20333461
Cancer (basal cell) GAD: 17107380
Cancer (Biliary tract neoplasms) GAD: 18676870
Cancer (bladder) GAD: 16110031
Cancer (brain) GAD: 17916900
Cancer (breast) GAD: 14735187
Cancer (cervical) GAD: 18337305
Cancer (colon) GAD: 18992263
Cancer (colorectal) GAD: 12839942
Chronic lymphocytic leukemia GAD: 10870116
Cancer (endometrial) INFBASE: 20074813
Kaposi's sarcoma OMIM: 147620
Cancer (Endometrial) GAD: 17023036
Cancer (epithelial ovarian) GAD: 19064572
Cancer (esophageal) GAD: 18502691
Cancer (gastric) GAD: 17950274
Cancer (Hepatocellular) GAD: 19126646
Cancer (kidney) GAD: 15784411
Cancer (leukemia) GAD: 12121679
Cancer (liver) GAD: 15763337
Cancer (lung) GAD: 14604894
Cancer (lymphoma) GAD: 18633131
Cancer (melanoma) GAD: 14675394
Cancer (mouth) GAD: 17177164
Cancer (myeloma) GAD: 11167813
Cancer (Neuroblastoma) GAD: 19671870
Cancer (noncardia gastric) GAD: 14753224
Cancer (non-Hodgkin lymphoma) GAD: 16449530
Cancer (non-melanoma skin cancer) GAD: 15914210
Cancer (osteosarcoma) GAD: 17483704
Cancer (ovarian) GAD: 15581980
Cancer (Papilary) GAD: 19494710
Cancer (prostate) GAD: 16618781
Cancer (Squamous cell) GAD: 19495883
Cancer (stomach) GAD: 16411061
Cancer (vulvar) GAD: 16198606
Cancer (Waldenstrom macroglobulinaemia) GAD: 19573080
Aneurysm GAD: 12756345
Angina pectoris GAD: 18927546
Apoplexy GAD: 20161734
Atherosclerosis GAD: 11895465
Atherosclerosis GAD: 11116068
Atrial fibrillation GAD: 12970232
Brain ischemia GAD: 19028820
Cerebral hemorrhage GAD: 15466088
Cerebral infarction GAD: 17016617
Hypertension GAD: 11196657
Intracranial aneurysm GAD: 18487018
Cardiovascular disease GAD: 11113012
Carotid artery diseases GAD: 12919773
Intracranial hemorrhage in brain cerebrovascular malformations OMIM: 147620
Peripheral vascular disease GAD: 19435865
Restenosis GAD: 12082592
Thromboembolism GAD: 17113632
Vascular disease GAD: 17115186
Brain infarction GAD: 18436879
Hemochromatosis GAD: 17847004
Gout GAD: 19032817
Gaucher disease GAD: 12897342
Fabry disease GAD: 18172744
Cystic fibrosis GAD: 17336597
Hyperandrogenism GAD: 11889177
Irritable bowel syndrome GAD: 19844779
Primary biliary cirrhosis GAD: 15562761
Hashimoto disease GAD: 17115419
Graves disease GAD: 16313297
Graves ophthalmopathy GAD: 19798110
Choroidal neovascularization GAD: 18235016
Macular degeneration GAD: 18310311
Macular edema GAD: 17024220
Uveitis GAD: 17005410
Blood coagulation disorders GAD: 20417488
Sarcoidosis GAD: 12737276
Castleman Disease KEGG: H01479
Mucocutaneous lymph node syndrome GAD: 21048327
Hodgkin disease GAD: 15070705
Lymphoproliferative disorders GAD: 16824159
Idiopathic thrombocytopenic purpura GAD: 15755291
Kawasaki disease GAD: 11704800
Aggressive periodontitis GAD: 18752567
Allergy GAD: 15120189
Ankylosing spondylitis GAD: 10852271
Arthritis GAD: 11315919
Asthma GAD: 18773331
Atopy GAD: 15005726
Autoimmune diseases GAD: 10843185
Autoimmune diseases GAD: 10843185
Behcet's disease GAD: 19796538
Behcet's disease GAD: 19796538
Bullous pemphigoid GAD: 16403098
Celiac disease GAD: 16540751
Crohn's disease GAD: 18799360
Sjogren's syndrome GAD: 14872501
Juvenile arthritis GAD: 15901906
Inflammatory bowel disease GAD: 11040178
Multiple sclerosis GAD: 11072134
Scleroderma GAD: 18576303
Systemic juvenile idiopathic arthritis GAD: 14613283
Psoriasis GAD: 19784523
Systemic lupus erythematosus (SLE) GAD: 11197305
Systemic lupus erythematosus (SLE) GAD: 2577114
Crohn's disease OMIM: 147620
Rheumatoid arthritis OMIM: 147620
Juvenile rheumatoid arthritis GAD: 9769329
Amyloidosis GAD: 16299685
Fatty liver GAD: 19403348
Insulin resistance GAD: 15919832
Metabolic syndrome GAD: 20080841
Obesity GAD: 19747414
Diabetes GAD: 12589429
Diabetes OMIM: 147620
Hypercholesterolemia GAD: 16607077
Hyperinsulinism GAD: 12540635
Rhabdomyolysis GAD: 18758806
Bone diseases GAD: 10865225
Bone diseases GAD: 11040178
Osteoarthritis GAD: 19036616
Osteolysis GAD: 18821666
Osteomyelitis GAD: 18971305
Osteoporosis GAD: 18652131
Spinal diseases GAD: 18469698
Juvenile idiopathic arthritis KEGG: H01672
Leukomalacia GAD: 19147624
Migraine disorder GAD: 19559392
Giant cell arteritis GAD: 12051396
Lacunar infarction GAD: 11983287
Stroke GAD: 16051899
Subarachnoid hemorrhage GAD: 15726267
Intracranial arteriovenous malformations GAD: 18841030
Myasthenia gravis GAD: 2577114
Alzheimer's disease GAD: 10632118
Parkinson disease GAD: 11072751
Acute pancreatitis GAD: 19220961
Cerebral palsy GAD: 19238444
Chronic fatigue syndrome GAD: 16762155
Attention deficit hyperactivity disorder (ADHD) GAD: 18580852
Bulimia GAD: 20468064
Depression GAD: 18458677
Mood disorders GAD: 19890236
Psychological disorders GAD: 12086705
Schizophrenia GAD: 14563376
Chronic renal failure GAD: 20551628
Kidney diseases GAD: 15104679
Kidney diseases GAD: 11544437
Abortion GAD: 20587610
Miscarriage GAD: 19778488
Preeclampsia GAD: 16433832
Recurrent pregnancy loss (RPL) GAD: 12571160
Preterm birth risk GAD: 19375805
Preterm birth risk GAD: 15516360
Infertility INFBASE: 8792937
Pelvic adhesions INFBASE: 11756364
Endometriosis INFBASE: 20160446
Premature ovarian insufficiency (POI) INFBASE: 22342295
Pelvic endometriosis INFBASE: 26871558
Deep infiltrating endometriosis INFBASE: 11327093
Ectopic endometriosis INFBASE: 17953945
Endometriosis INFBASE: 12845737
Endometriosis-associated infertility INFBASE: 17688616
Female infertility INFBASE: 11821289
Poor ovarian response (POR) INFBASE: 25083184
Infertility INFBASE: 9077612
Genital endometriosis INFBASE: 16758620
Hypothalamic amenorrhea INFBASE: 17094981
Implantation failure INFBASE: 26952510
Endometriosis INFBASE: 17062580
Recurrent implantation failure (RIF) INFBASE: 22201617
External gential endometriosis INFBASE: 16027877
Female infertility INFBASE: 8224268
Primary unexplained infertility INFBASE: 12161539
Polycystic ovary syndrome (PCOS) INFBASE: 26177495
Ovarian endometriosis INFBASE: 27337799
Lower implantation INFBASE: 16705074
Ovarian hyperstimulation syndrome (OHSS) INFBASE: 23348396
Recurrent pregnancy loss (RPL) INFBASE: 26952510
Ovarian inflammation INFBASE: 25539190
Ovarian dysfunction INFBASE: 16579166
Unexplained infertility INFBASE: 17688616
Tubal factor infertility INFBASE: 9811536
Turners syndrome INFBASE: 22342295
Oligoasthenozoospermia MIK: 19239426
Male factor infertility MIK: 25597177
Impaired human spermatogenesis MIK: 19527232
Leukocytospermia MIK: 12619318
Male subfertility MIK: 19811461
Male factor infertility MIK: 12619318
Oligoasthenozoospermia MIK: 12619318
Male factor infertility MIK: 21244563
Asthenozoospermia MIK: 19239426
Sperm motility MIK: 8723440
Varicocele MIK: 8822435
Asthenozoospermia MIK: 24029665
Spermatogenesis defects MIK: 15166129
Subfertility MIK: 19811461
Prostatitis MIK: 24329571
Prostato-vesiculitis MIK: 24329571
Premature adrenarche MIK: 22654787
Testicular dysfunction MIK: 8822435
Male factor infertility MIK: 16266398
Varicocele MIK: 15533496
Oligozoospermia MIK: 17341438
Male factor infertility MIK: 15533496
Normozoospermia MIK: 24029665
Endometriosis-associated infertility INFBASE: 15166129
Female infertility INFBASE: 25797583
Female infertility INFBASE: 24576416
Chronic obstructive pulmonary disease (COPD) GAD: 18364273
Interstitial lung diseases GAD: 19117745
Pulmonary embolism GAD: 16676071
Pulmonary fibrosis GAD: 11371414
Obstructive sleep apnea GAD: 19218687
Dermatitis GAD: 12694213
Erythema GAD: 19225544
Takayasu arteritis GAD: 17002904
Pemphigus vulgaris GAD: 19470040
Connective tissue diseases GAD: 19527514
Periodontal disease GAD: 15341923
Alpha 1-antitrypsin deficiency GAD: 17690329
Alveolitis GAD: 16722148
Asphyxia neonatorum GAD: 16181755
Barrett's esophagus GAD: 18192685
Bronchiolitis GAD: 12451269
Bronchitis GAD: 15686588
Cachexia GAD: 18469355
Ischemia GAD: 19919828
Respiratory distress syndrome GAD: 18593632
Periventricular mental retardation GAD: 19147624
Nephropathy GAD: 11849463
Nephrotic syndrome GAD: 19008611
Uterine diseases GAD: 18930197
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Celiac disease MIK: 26662429
Spermatogenic defects MIK: 19527232
Leukocytospermia MIK: 12619318
Oligoasthenozoospermia MIK: 12619318
Leydig cell development MIK: 29180110
Male immune infertility MIK: 25597177
Male infertility MIK: 11554690
Prostatitis and prostato-vesiculitis MIK: 24329571
Sperm autoantibodies MIK: 19239426
Asthenozoospermia MIK: 19239426
Oligozoospermia MIK: 24029665
Azoospermia MIK: 8822435
Premature Adrenarche MIK: 22654787
Endometriosis-associated infertility MIK: 15166129
Subfertile men MIK: 19811461
Testicular dysfunction MIK: 8822435
Varicocele MIK: 15533496

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
19811461 Male subfe
rtility

75 male partner
s of an inferti
le couple
Male infertility IL-6
IL-8
IL-10
IL-11
IL-12
 TNF-alpha and IFN-gamma
Show abstract
19527232 Male infer
tility

10 patients obt
ained from pati
ents who had un
dergone orchide
c-tomy resultin
g from prostati
c cancer treatm
ent
Male infertility IL-6
IL-10
 TNF-alpha
TNFR1 and TNFR2
Show abstract
11554690 Infertilit
y

51 (37 infertil
e and 14 fertil
e men)
Male infertility TNF-alpha
Show abstract
7928663 Male infer
tility

28 (15 infertil
e men, 10 ferti
le men)
Male infertility TNF-alpha
IFN-gamma
IL-1 beta
IL-9
Show abstract
26662429 Celiac dis
ease
Italian
(North
east)
288 ((96 DQ2-po
sitive and 96 D
Q8-positive), 9
6 controls)
Male infertility, Female infertility IL-6
TNF-?
Show abstract
26648778 Male infer
tility

82 (27 healthy
controls, 55 in
fertile patient
s (22 patients
with varicocele
, 13 with idiop
athic infertili
ty) )
Male infertility IL-1?
IL-10
IL-18
TGF-?1
IFN-g
IL-6
Show abstract
25597177 Male immun
e infertil
ity

123 (immune inf
ertility group
(n = 41), other
infertility gr
oup A (n = 37),
and other infe
rtility group B
(n = 45))
Male infertility IL6
 ICAM-1
Show abstract
24830311 Male infer
tility

110 azoospermic
men
Male infertility IL-6
TNF-?
Show abstract
24029665 Normozoosp
ermic (idi
opathic un
explained)
, oligozoo
spermic an
d asthenoz
oospermic 
TNF-? G-308A, IL-6 G-174C substitution Uttar P
radesh
populat
ion in
North I
ndia
520 (260 contro
ls, 260 inferti
le patients)
Male infertility TNF-?
IL-6
Show abstract
20576636 Infertilit
y

96 (male infert
ility, n = 61;
female infertil
ity factors, n
= 35)
Male infertility, Female infertility
Show abstract
22654787 Premature
Adrenarche
TNF-? gene -308 G?>?A polymorphism
171 (73 childre
n with PA and 9
8 age- and gend
er-matched cont
rols)
Male infertility, Female infertility TNF-?
IL-6
Show abstract
19811461 Subfertile
men

73 male partner
s
Male infertility IL-6
IL-10
TNF-alpha
IFN-gamma
Show abstract
19527232 Impaired h
uman sperm
atogenesis

39 (10 controls
, 29 azoospermi
c patients (9 S
ertoli cell onl
y syndrome, 7 u
ndefined matura
tion arrest, 4
maturation arre
st at a spermat
ocyte stage, 3
maturation arre
st at a spermat
id stage and OA
, 6 obstructive
azospermia )
)
Male infertility IL-6
IL-10
TNF-alpha
TNFR1 and TNFR2
Show abstract
17341438 Oligozoosp
ermia, ast
henozoospe
rmia

62 (34 controls
, 28 men with o
ligozoospermia
or asthenozoosp
ermia)
Male infertility IL-6
IL-8
VEGF
TNFalpha
IL-1beta
TGFbeta1 and G-CSF
Show abstract
14555327 Male infer
tility


Male infertility Fas
IL-6
IL-8
Show abstract
12623747 Male infer
tility

70 (45 infertil
e undiagnosed a
nd 25 fertile m
en)
Male infertility IL-10
IL-6
Show abstract
11554690 Male infer
tility

51 (37 infertil
e and 14 fertil
e men)
Male infertility IL-6
TNF-alpha
Show abstract
24329571 Male infer
tility, pr
ostatitis
and prosta
to-vesicul
itis

211 (169 infert
ile patients (7
4 chronic bacte
rial prostatiti
s, 95 bilateral
prostato-vesic
ulitis), 42 fer
tile men)
Male infertility TNF-?
IL-6
IL-10
Show abstract
12623747 Male infer
tility

70 (45 infertil
e undiagnosed a
nd 25 fertile m
en)
Male infertility IL10
IL6
Show abstract
19811461 Obstructed
azoosperm
ia, asthen
ospermia

73 male partner
s of an inferti
le couple atten
ding a regional
andrology unit
 
Male infertility  IL-6
IL-8
IL-10
IL-11
IL-12
TNF-alpha and IFN-gamma
Show abstract
14555327 Male infer
tility


Male infertility Fas
IL-6 and IL-8
Show abstract
12623747 Male infer
tility

70 (45 infertil
e, 25 fertile m
en )
Male infertility PGE(2)
IL-10
and IL-6
Show abstract
15166129 Reduced sp
erm motili
ty, endome
triosis-as
sociated i
nfertility

20
Male infertility
Show abstract
19239426 Male infer
tility, Sp
erm autoan
tibodies,
oligoasthe
nospermia,
asthenosp
ermia


Male infertility IL-1beta
IL-2
 IL-4
IL-5
IL-6
IL-8
IL-10
IL-12p70 TNF-alpha
and IFN-gamma
Show abstract
11076089 Sperm moti
lity

83 infertile pa
tients
Male infertility
Show abstract
12619318 Leukocytos
permia, ol
igoastheno
zoospermia

52 (16 fertile
men, 16 with le
ukocytospermia,
20 with oligoa
sthenozoospermi
a)
Male infertility IL-2
IL-6
Show abstract
16266398 Sperm moti
lity

340 patients to
investigate ge
nital tract inf
lammation
Male infertility IL-6
elastase
Show abstract
15533496 Varicocele
, male inf
ertility

50 (15 fertile
donors (control
s), 35 infertil
e patients with
varicocele)
Male infertility
Show abstract
10875860 Sperm moti
lity


Male infertility HGF
Show abstract
9262280 Male infer
tility

140 (21 fertile
subjects, 119
patients with a
range of andro
logical disease
s)
Male infertility IL-beta
IL-2
IL-6
sR IL-2
SR IL-6
Show abstract
9272207 Male infer
tility

38 (18 fertile,
20 infertile s
ubjects)
Male infertility IL-4
IL-6
Show abstract
8723440 Sperm moti
lity, male
infertili
ty

22 (14 infertil
e males, 8 heal
thy control sub
jects)
Male infertility IL-1
IL-6
TNF alpha
Show abstract
12202945 Male infer
tility

79 (24 fertile
men, 55 inferti
le men (23 vari
cocele, 14 pati
ents post varic
ocelectomy (pos
t-varicocele),
10 male accesso
ry gland infect
ion, 8 bilatera
l testicular at
rophy )
Male infertility IL-6
TNF-alpha
Show abstract
8822435 Oligozoosp
ermia, Azo
ospermia,
asthenozoo
spermia, v
aricocele

217 (beta-endor
phin (28 oligoz
oospermic, 15 a
sthenozoospermi
c, 4 azoospermi
c, 7 post-vasec
tomy), IL-6 (46
oligozoospermi
c, 32 asthenozo
ospermic, 13 az
oospermic, 10 p
ost-vasectomy,
39 normozoosper
mic))
Male infertility beta-endorphin
IL-6
Show abstract
29180110 Leydig cel
l developm
ent, Male
infertilit
y


Male infertility
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract