• Gene id: 3565

Gene Summary

• Gene Symbol: IL4   Gene   UCSC   Ensembl
• Aliases: BCGF-1, BCGF1, BSF-1, BSF1, IL-4
• Gene name: interleukin 4
• Alternate names: interleukin-4, B cell growth factor 1, B_cell stimulatory factor 1, binetrakin, interleukin 4 variant 2, lymphocyte stimulatory factor 1, pitrakinra,
• Gene location: 5q31.1 (132673985: 132682677)     Exons: 5     NC_000005.10
• Gene summary(Entrez): The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytok
• OMIM: 147780

Protein Summary

• Protein general information: P05112  
  • Name: Interleukin 4 (IL 4) (B cell stimulatory factor 1) (BSF 1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
  • Length: 153  
  • Mass: 17,492
• Sequence:

  MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATV
  LRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSK
  CSS

• Structural information:
  • Interpro: IPR009079  IPR002354  IPR001325  IPR018096  
  • Prosite: PS00838
  • PDB: 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX
  • PDBsum: 1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX
  • DIP: 3222
  • STRING: ENSP00000231449
• Other Databases: GeneCards:  IL4  Malacards:  IL4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001774	microglial cell activation	IEA	biological process
GO:0002227	innate immune response in mucosa	IEA	biological process
GO:0002230	positive regulation of defense response to virus by host	IEA	biological process
GO:0002296	T-helper 1 cell lineage commitment	IEA	biological process
GO:0002674	negative regulation of acute inflammatory response	IEA	biological process
GO:0002677	negative regulation of chronic inflammatory response	IEA	biological process
GO:0005125	cytokine activity	IBA	molecular function
GO:0005136	interleukin-4 receptor binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005615	extracellular space	TAS	cellular component
GO:0006935	chemotaxis	TAS	biological process
GO:0006955	immune response	TAS	biological process
GO:0006968	cellular defense response	TAS	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0007584	response to nutrient	IEA	biological process
GO:0008083	growth factor activity	NAS	molecular function
GO:0008203	cholesterol metabolic process	ISS	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0010155	regulation of proton transport	IEA	biological process
GO:0010633	negative regulation of epithelial cell migration	IDA	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0030183	B cell differentiation	TAS	biological process
GO:0030890	positive regulation of B cell proliferation	ISS	biological process
GO:0031296	B cell costimulation	IEA	biological process
GO:0032733	positive regulation of interleukin-10 production	IEA	biological process
GO:0032736	positive regulation of interleukin-13 production	IDA	biological process
GO:0034097	response to cytokine	IEA	biological process
GO:0035745	T-helper 2 cell cytokine production	IDA	biological process
GO:0042092	type 2 immune response	TAS	biological process
GO:0042102	positive regulation of T cell proliferation	ISS	biological process
GO:0042104	positive regulation of activated T cell proliferation	IEA	biological process
GO:0042325	regulation of phosphorylation	ISS	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	IEA	biological process
GO:0042832	defense response to protozoan	IEA	biological process
GO:0043011	myeloid dendritic cell differentiation	IDA	biological process
GO:0043031	negative regulation of macrophage activation	IEA	biological process
GO:0043066	negative regulation of apoptotic process	ISS	biological process
GO:0043306	positive regulation of mast cell degranulation	IEA	biological process
GO:0045019	negative regulation of nitric oxide biosynthetic process	IEA	biological process
GO:0045064	T-helper 2 cell differentiation	IEA	biological process
GO:0045080	positive regulation of chemokine biosynthetic process	IEA	biological process
GO:0045189	connective tissue growth factor biosynthetic process	TAS	biological process
GO:0045191	regulation of isotype switching	TAS	biological process
GO:0045348	positive regulation of MHC class II biosynthetic process	ISS	biological process
GO:0045471	response to ethanol	IEA	biological process
GO:0045582	positive regulation of T cell differentiation	IDA	biological process
GO:0045671	negative regulation of osteoclast differentiation	ISS	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISS	biological process
GO:0048295	positive regulation of isotype switching to IgE isotypes	ISS	biological process
GO:0048304	positive regulation of isotype switching to IgG isotypes	ISS	biological process
GO:0050776	regulation of immune response	ISS	biological process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IBA	biological process
GO:0060041	retina development in camera-type eye	IEA	biological process
GO:0070351	negative regulation of white fat cell proliferation	IEA	biological process
GO:0071288	cellular response to mercury ion	IEA	biological process
GO:0071677	positive regulation of mononuclear cell migration	IEA	biological process
GO:0097028	dendritic cell differentiation	IDA	biological process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IEA	biological process
GO:1901741	positive regulation of myoblast fusion	IEA	biological process
GO:1903660	negative regulation of complement-dependent cytotoxicity	IMP	biological process
GO:2000320	negative regulation of T-helper 17 cell differentiation	IEA	biological process
GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	biological process
GO:2000424	positive regulation of eosinophil chemotaxis	IEA	biological process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IEA	biological process
GO:0001774	microglial cell activation	IEA	biological process
GO:0001934	positive regulation of protein phosphorylation	IEA	biological process
GO:0002227	innate immune response in mucosa	IEA	biological process
GO:0002230	positive regulation of defense response to virus by host	IEA	biological process
GO:0002296	T-helper 1 cell lineage commitment	IEA	biological process
GO:0002639	positive regulation of immunoglobulin production	IEA	biological process
GO:0002674	negative regulation of acute inflammatory response	IEA	biological process
GO:0002677	negative regulation of chronic inflammatory response	IEA	biological process
GO:0005125	cytokine activity	IEA	molecular function
GO:0005125	cytokine activity	IBA	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0005126	cytokine receptor binding	IEA	molecular function
GO:0005136	interleukin-4 receptor binding	IEA	molecular function
GO:0005136	interleukin-4 receptor binding	TAS	molecular function
GO:0005136	interleukin-4 receptor binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	TAS	cellular component
GO:0005615	extracellular space	TAS	cellular component
GO:0006935	chemotaxis	TAS	biological process
GO:0006955	immune response	IEA	biological process
GO:0006955	immune response	TAS	biological process
GO:0006968	cellular defense response	TAS	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0007584	response to nutrient	IEA	biological process
GO:0008083	growth factor activity	IEA	molecular function
GO:0008083	growth factor activity	IEA	molecular function
GO:0008083	growth factor activity	NAS	molecular function
GO:0008203	cholesterol metabolic process	IEA	biological process
GO:0008203	cholesterol metabolic process	ISS	biological process
GO:0008284	positive regulation of cell proliferation	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0010155	regulation of proton transport	IEA	biological process
GO:0010633	negative regulation of epithelial cell migration	IDA	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0030183	B cell differentiation	TAS	biological process
GO:0030890	positive regulation of B cell proliferation	IEA	biological process
GO:0030890	positive regulation of B cell proliferation	ISS	biological process
GO:0031296	B cell costimulation	IEA	biological process
GO:0032733	positive regulation of interleukin-10 production	IEA	biological process
GO:0032736	positive regulation of interleukin-13 production	IDA	biological process
GO:0034097	response to cytokine	IEA	biological process
GO:0035745	T-helper 2 cell cytokine production	IDA	biological process
GO:0042092	type 2 immune response	TAS	biological process
GO:0042102	positive regulation of T cell proliferation	IEA	biological process
GO:0042102	positive regulation of T cell proliferation	ISS	biological process
GO:0042104	positive regulation of activated T cell proliferation	IEA	biological process
GO:0042113	B cell activation	IEA	biological process
GO:0042113	B cell activation	IEA	biological process
GO:0042325	regulation of phosphorylation	ISS	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	IEA	biological process
GO:0042832	defense response to protozoan	IEA	biological process
GO:0043011	myeloid dendritic cell differentiation	IDA	biological process
GO:0043031	negative regulation of macrophage activation	IEA	biological process
GO:0043066	negative regulation of apoptotic process	ISS	biological process
GO:0043306	positive regulation of mast cell degranulation	IEA	biological process
GO:0045019	negative regulation of nitric oxide biosynthetic process	IEA	biological process
GO:0045064	T-helper 2 cell differentiation	IEA	biological process
GO:0045080	positive regulation of chemokine biosynthetic process	IEA	biological process
GO:0045189	connective tissue growth factor biosynthetic process	TAS	biological process
GO:0045191	regulation of isotype switching	TAS	biological process
GO:0045348	positive regulation of MHC class II biosynthetic process	IEA	biological process
GO:0045348	positive regulation of MHC class II biosynthetic process	ISS	biological process
GO:0045471	response to ethanol	IEA	biological process
GO:0045582	positive regulation of T cell differentiation	IDA	biological process
GO:0045671	negative regulation of osteoclast differentiation	IEA	biological process
GO:0045671	negative regulation of osteoclast differentiation	ISS	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IEA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISS	biological process
GO:0048295	positive regulation of isotype switching to IgE isotypes	IEA	biological process
GO:0048295	positive regulation of isotype switching to IgE isotypes	ISS	biological process
GO:0048304	positive regulation of isotype switching to IgG isotypes	IEA	biological process
GO:0048304	positive regulation of isotype switching to IgG isotypes	ISS	biological process
GO:0050727	regulation of inflammatory response	IEA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0050776	regulation of immune response	IEA	biological process
GO:0050776	regulation of immune response	ISS	biological process
GO:0050868	negative regulation of T cell activation	IEA	biological process
GO:0050871	positive regulation of B cell activation	IEA	biological process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IEA	biological process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IBA	biological process
GO:0060041	retina development in camera-type eye	IEA	biological process
GO:0070351	negative regulation of white fat cell proliferation	IEA	biological process
GO:0071288	cellular response to mercury ion	IEA	biological process
GO:0071677	positive regulation of mononuclear cell migration	IEA	biological process
GO:0097028	dendritic cell differentiation	IDA	biological process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IEA	biological process
GO:1901741	positive regulation of myoblast fusion	IEA	biological process
GO:1903660	negative regulation of complement-dependent cytotoxicity	IMP	biological process
GO:2000320	negative regulation of T-helper 17 cell differentiation	IEA	biological process
GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	biological process
GO:2000424	positive regulation of eosinophil chemotaxis	IEA	biological process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IEA	biological process
GO:0005125	cytokine activity	IBA	molecular function
GO:0005136	interleukin-4 receptor binding	TAS	molecular function
GO:0005136	interleukin-4 receptor binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005615	extracellular space	TAS	cellular component
GO:0005615	extracellular space	TAS	cellular component
GO:0006935	chemotaxis	TAS	biological process
GO:0006955	immune response	TAS	biological process
GO:0006968	cellular defense response	TAS	biological process
GO:0008083	growth factor activity	NAS	molecular function
GO:0008203	cholesterol metabolic process	ISS	biological process
GO:0010633	negative regulation of epithelial cell migration	IDA	biological process
GO:0030183	B cell differentiation	TAS	biological process
GO:0030890	positive regulation of B cell proliferation	ISS	biological process
GO:0032736	positive regulation of interleukin-13 production	IDA	biological process
GO:0035745	T-helper 2 cell cytokine production	IDA	biological process
GO:0042092	type 2 immune response	TAS	biological process
GO:0042102	positive regulation of T cell proliferation	ISS	biological process
GO:0042325	regulation of phosphorylation	ISS	biological process
GO:0043011	myeloid dendritic cell differentiation	IDA	biological process
GO:0043066	negative regulation of apoptotic process	ISS	biological process
GO:0045189	connective tissue growth factor biosynthetic process	TAS	biological process
GO:0045191	regulation of isotype switching	TAS	biological process
GO:0045348	positive regulation of MHC class II biosynthetic process	ISS	biological process
GO:0045582	positive regulation of T cell differentiation	IDA	biological process
GO:0045671	negative regulation of osteoclast differentiation	ISS	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISS	biological process
GO:0048295	positive regulation of isotype switching to IgE isotypes	ISS	biological process
GO:0048304	positive regulation of isotype switching to IgG isotypes	ISS	biological process
GO:0050776	regulation of immune response	ISS	biological process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IBA	biological process
GO:0097028	dendritic cell differentiation	IDA	biological process
GO:1903660	negative regulation of complement-dependent cytotoxicity	IMP	biological process
GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04640	Hematopoietic cell lineage
hsa04660	T cell receptor signaling pathway
hsa04658	Th1 and Th2 cell differentiation
hsa04659	Th17 cell differentiation
hsa04657	IL-17 signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04672	Intestinal immune network for IgA production
hsa05200	Pathways in cancer
hsa05310	Asthma
hsa05320	Autoimmune thyroid disease
hsa05321	Inflammatory bowel disease
hsa05330	Allograft rejection
hsa05140	Leishmaniasis

Diseases

Associated diseases	References
Cancer (noncardia gastric)	GAD: 14753224
Cancer (non-Hodgkin lymphoma)	GAD: 16449530
Cancer (prostate)	GAD: 18694328
Cancer (Renal cell)	GAD: 17327605
Cancer (Squamous cell)	GAD: 19495883
Cancer (stomach)	GAD: 16289646
Brill-Symmers disease	GAD: 17653830
Cancer	GAD: 14675394
Cancer (Adenocarcinoma)	GAD: 18628242
Cancer (Biliary tract neoplasms)	GAD: 18676870
Cancer (bladder)	GAD: 16938461
Cancer (brain)	GAD: 17548690
Cancer (Central nervous system)	GAD: 20299965
Cancer (colorectal)	GAD: 17454884
Cancer (esophageal)	GAD: 19801321
Cancer (Hepatocellular)	GAD: 19126646
Cancer (leiomyoma)	GAD: 17222831
Cancer (leukemia)	GAD: 15932621
Cancer (lung)	GAD: 18676680
Cancer (lymphoma)	GAD: 18633131
Cancer (melanoma)	GAD: 14675394
Cancer (mouth)	GAD: 15900573
Cancer (myeloma)	GAD: 20568250
Cancer (breast)	GAD: 19544973
Apoplexy	GAD: 14681304
Atherosclerosis	GAD: 19347053
Cardiovascular disease	GAD: 16184405
Cerebral infarction	GAD: 18696265
Coronary heart disease	GAD: 20364398
Brain ischemia	GAD: 19028820
Restenosis	GAD: 12082592
Bronchopulmonary dysplasia	GAD: 15627726
Irritable bowel syndrome	GAD: 20177758
Gastric atrophy	GAD: 15904474
Necrotizing enterocolitis	GAD: 14523823
Hyperparathyroidism	GAD: 20424473
Graves disease	GAD: 16195814
Sarcoidosis	GAD: 21086908
Hemophilia	GAD: 16380445
Mucocutaneous lymph node syndrome	GAD: 21048327
Hodgkin disease	GAD: 21061265
Idiopathic thrombocytopenic purpura	GAD: 15755291
Kawasaki disease	GAD: 15900570
Aggressive periodontitis	GAD: 19892918
Allergy	GAD: 17209513
Ankylosing spondylitis	GAD: 20030788
Arthritis	GAD: 11315919
Asthma	GAD: 11202474
Bronchial hyperreactivity	GAD: 19536153
Asthma	GAD: 11704288
Celiac disease	GAD: 15713213
Crohn's disease	GAD: 11294568
Sjogren's syndrome	GAD: 16166103
Ulcerative colitis	GAD: 12133437
Rheumatoid arthritis	GAD: 11035134
Multiple sclerosis	GAD: 12667657
Scleroderma	GAD: 20603050
Psoriasis	GAD: 11298547
Systemic lupus erythematosus (SLE)	GAD: 12587822
Atopy	GAD: 15969687
Autoimmune diseases	GAD: 20082482
Bullous pemphigoid	GAD: 16403098
Juvenile arthritis	GAD: 15170937
Hypersensitivity	GAD: 20413987
Cholelithiasis	GAD: 16083600
Diabetes	GAD: 16100774
Degenerative arthropathy	GAD: 20219689
Osteomyelitis	GAD: 18971305
Bone diseases	GAD: 16520888
Fibromyalgia	GAD: 16547693
Idiopathic inflammatory myopathies	GAD: 17405833
Rheumatic diseases	GAD: 16043936
Migraine disorder	GAD: 19559392
Giant cell arteritis	GAD: 15570643
Alzheimer's disease	GAD: 19141999
Parkinson disease	GAD: 18568448
Cerebral palsy	GAD: 19566553
Schizophrenia	GAD: 16091861
Albuminuria	GAD: 21054877
Chronic renal failure	GAD: 21085059
Kidney diseases	GAD: 17524861
Abortion	GAD: 15274656
Chorioamnionitis	GAD: 20452482
Placenta diseases	GAD: 18156980
Preeclampsia	GAD: 18651887
Recurrent pregnancy loss (RPL)	GAD: 15811521
Recurrent pregnancy loss (RPL)	GAD: 15811521
Spontaneous abortion	GAD: 15042002
Pelvic endometriosis	INFBASE: 26871558
Multiple implantation failures	INFBASE: 12660269
Endometriosis	INFBASE: 11264613
Female infertility	INFBASE: 11968047
Female infertility	INFBASE: 26871558
Unexplained infertility	INFBASE: 12607776
Recurrent pregnancy loss (RPL)	INFBASE: 12660269
Unexplained infertility	INFBASE: 24368037
Male factor infertility	MIK: 15595690
Leukocytospermia	MIK: 10509791
Female infertility	INFBASE: 24368037
Chronic obstructive pulmonary disease (COPD)	GAD: 19625176
Interstitial lung diseases	GAD: 19117745
Pulmonary fibrosis	GAD: 16573560
Asthma	GAD: 10810222
Rhinitis	GAD: 19222422
Eczema	GAD: 17121586
Dermatitis	GAD: 11922633
Vitiligo	GAD: 19129082
Atopic dermatitis	GAD: 9643293
Atopic eczema	GAD: 11678851
Pemphigus vulgaris	GAD: 19470040
Connective tissue diseases	GAD: 19527514
Chronic periodontitis	GAD: 18834248
Nephropathy	GAD: 12552499
Nephrosis	GAD: 16053729
Nephrotic syndrome	GAD: 11980568
Minimal change nephrotic syndrome	GAD: 12900808
Male infertility	MIK: 9272207
Leukocytospermia	MIK: 10509791

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
15595690	Male infertility			146 (126 infertile males, 20 males)	Male infertility	IL1b IL4 IL10
10509791	Male infertility with leukocytospermia			200 (176 infertile men, 24 fertile controls )	Male infertlity	TNFalpha  IL-4
9272207	Male infertility			38 (18 fertile, 20 infertile subjects)	Male infertility	IL-4 IL-6