Gene id |
3561 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
IL2RG Gene UCSC Ensembl |
Aliases |
CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1 |
Gene name |
interleukin 2 receptor subunit gamma |
Alternate names |
cytokine receptor common subunit gamma, CD132 antigen, IL-2 receptor subunit gamma, IL-2R subunit gamma, common cytokine receptor gamma chain, gammaC, interleukin 2 receptor, gamma, nonfunctional common cytokine receptor gamma chain, |
Gene location |
Xq13.1 (71111576: 71107403) Exons: 8 NC_000023.11
|
Gene summary(Entrez) |
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined
|
OMIM |
120215 |
Protein Summary
|
Protein general information
| P31785
Name: Cytokine receptor common subunit gamma (Interleukin 2 receptor subunit gamma) (IL 2 receptor subunit gamma) (IL 2R subunit gamma) (IL 2RG) (gammaC) (p64) (CD antigen CD132)
Length: 369 Mass: 42287
|
Sequence |
MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWN SSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQN LVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRS RFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLV TEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET
|
Structural information |
|
Other Databases |
GeneCards: IL2RG Malacards: IL2RG |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0004896 |
cytokine receptor activit y
|
IBA |
molecular function |
GO:0009897 |
external side of plasma m embrane
|
IBA |
cellular component |
GO:0019976 |
interleukin-2 binding
|
IBA |
molecular function |
GO:0019221 |
cytokine-mediated signali ng pathway
|
IBA |
biological process |
GO:0019955 |
cytokine binding
|
IBA |
molecular function |
GO:0043235 |
receptor complex
|
IBA |
cellular component |
GO:0004896 |
cytokine receptor activit y
|
IEA |
molecular function |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0005886 |
plasma membrane
|
IEA |
cellular component |
GO:0016032 |
viral process
|
IEA |
biological process |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0005887 |
integral component of pla sma membrane
|
TAS |
cellular component |
GO:0006955 |
immune response
|
TAS |
biological process |
GO:0007165 |
signal transduction
|
NAS |
biological process |
GO:0000165 |
MAPK cascade
|
TAS |
biological process |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0035723 |
interleukin-15-mediated s ignaling pathway
|
TAS |
biological process |
GO:0005768 |
endosome
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0019221 |
cytokine-mediated signali ng pathway
|
TAS |
biological process |
GO:0019221 |
cytokine-mediated signali ng pathway
|
TAS |
biological process |
GO:0019221 |
cytokine-mediated signali ng pathway
|
TAS |
biological process |
GO:0038110 |
interleukin-2-mediated si gnaling pathway
|
TAS |
biological process |
GO:0038111 |
interleukin-7-mediated si gnaling pathway
|
TAS |
biological process |
GO:0038113 |
interleukin-9-mediated si gnaling pathway
|
TAS |
biological process |
GO:0038114 |
interleukin-21-mediated s ignaling pathway
|
TAS |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005886 |
plasma membrane
|
IEA |
cellular component |
GO:0009986 |
cell surface
|
IEA |
cellular component |
GO:0035771 |
interleukin-4-mediated si gnaling pathway
|
IEA |
biological process |
GO:0042010 |
interleukin-15 receptor a ctivity
|
IDA |
molecular function |
GO:0009986 |
cell surface
|
IDA |
cellular component |
GO:0016020 |
membrane
|
HDA |
cellular component |
GO:0035723 |
interleukin-15-mediated s ignaling pathway
|
IMP |
biological process |
GO:0004917 |
interleukin-7 receptor ac tivity
|
TAS |
contributes to |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0004913 |
interleukin-4 receptor ac tivity
|
TAS |
contributes to |
GO:0004911 |
interleukin-2 receptor ac tivity
|
TAS |
contributes to |
GO:0050766 |
positive regulation of ph agocytosis
|
IMP |
biological process |
GO:0019976 |
interleukin-2 binding
|
ISS |
molecular function |
GO:0009897 |
external side of plasma m embrane
|
ISS |
cellular component |
|
|
|
|
Associated diseases |
References |
Combined immunodeficiency | KEGG:H00093 |
T-B+Severe combined immunodeficiency | KEGG:H00091 |
Combined immunodeficiency | KEGG:H00093 |
T-B+Severe combined immunodeficiency | KEGG:H00091 |
severe combined immunodeficiency | PMID:7557965 |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|