• Gene id: 353322

Gene Summary

• Gene Symbol: ANKRD37   Gene   UCSC   Ensembl
• Aliases: Lrp2bp
• Gene name: ankyrin repeat domain 37
• Alternate names: ankyrin repeat domain-containing protein 37, low density lipoprotein receptor-related protein binding protein, low-density lipoprotein receptor-related protein 2-binding protein,
• Gene location: 4q35.1 (185396840: 185400242)     Exons: 4     NC_000004.12

Protein Summary

• Protein general information: Q7Z713  
  • Name: Ankyrin repeat domain containing protein 37 (Low density lipoprotein receptor related protein 2 binding protein) (hLrp2bp)
  • Length: 158  
  • Mass: 16872
  • Tissue specificity: Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells. {ECO
• Sequence:

  MLLLDCNPEVDGLKHLLETGASVNAPPDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVG
  SLECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPDCAKFLTTIKCMQTIKASEHPDRNDCVAVLRQKRSLGSVE
  NTSGKRKC

• Structural information:
  • Interpro: IPR002110  IPR020683  IPR036770  
  • Prosite: PS50297 PS50088
  • STRING: ENSP00000335147
• Other Databases: GeneCards:  ANKRD37  Malacards:  ANKRD37

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881