• Gene id: 3491

Gene Summary

• Gene Symbol: CCN1   Gene   UCSC   Ensembl
• Aliases: CYR61, GIG1, IGFBP10
• Gene name: cellular communication network factor 1
• Alternate names: CCN family member 1, IBP-10, IGF-binding protein 10, IGFBP-10, cysteine rich angiogenic inducer 61, cysteine-rich heparin-binding protein 61, cysteine-rich, anigogenic inducer, 61, insulin-like growth factor-binding protein 10, protein CYR61,
• Gene location: 1p22.3 (85580760: 85583949)     Exons: 5     NC_000001.11
• Gene summary(Entrez): The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell prolife
• OMIM: 602369

Protein Summary

• Protein general information: O00622  
  • Name: CCN family member 1 (Cellular communication network factor 1) (Cysteine rich angiogenic inducer 61) (Insulin like growth factor binding protein 10) (IBP 10) (IGF binding protein 10) (IGFBP 10) (Protein CYR61) (Protein GIG1)
  • Length: 381  
  • Mass: 42027
• Sequence:

  MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKG
  LECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRL
  VKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQ
  GQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
  AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFND
  IHKFRD

• Structural information:
  • Protein Domains: (25..9-)
    (/note="IGFBP-N-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00653-)
    (98..16-)
    (/note="VWFC-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00220-)
    (228..27-)
    (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PR-)
  • Interpro: IPR006207  IPR006208  IPR009030  IPR000867  IPR012395   IPR017891  IPR000884  IPR036383  IPR001007  
  • Prosite: PS01185 PS01225 PS00222 PS51323 PS50092 PS01208 PS50184
  • PDB: 4D0Z 4D11
  • PDBsum: 4D0Z 4D11
  • STRING: ENSP00000398736
• Other Databases: GeneCards:  CCN1  Malacards:  CCN1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007165	signal transduction	IBA	biological process
GO:0031012	extracellular matrix	IBA	cellular component
GO:0060548	negative regulation of cell death	IBA	biological process
GO:0005178	integrin binding	IBA	molecular function
GO:0007155	cell adhesion	IBA	biological process
GO:0008201	heparin binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005520	insulin-like growth factor binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0019838	growth factor binding	IEA	molecular function
GO:0007155	cell adhesion	IEA	biological process
GO:0006935	chemotaxis	IEA	biological process
GO:0008201	heparin binding	IEA	molecular function
GO:0044267	cellular protein metabolic process	TAS	biological process
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0043687	post-translational protein modification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0098609	cell-cell adhesion	IEA	biological process
GO:0061036	positive regulation of cartilage development	IEA	biological process
GO:0060716	labyrinthine layer blood vessel development	IEA	biological process
GO:0060413	atrial septum morphogenesis	IEA	biological process
GO:0050840	extracellular matrix binding	IEA	molecular function
GO:0045597	positive regulation of cell differentiation	IEA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0030335	positive regulation of cell migration	IEA	biological process
GO:0010811	positive regulation of cell-substrate adhesion	IEA	biological process
GO:0001649	osteoblast differentiation	IEA	biological process
GO:2000304	positive regulation of ceramide biosynthetic process	IEA	biological process
GO:0072593	reactive oxygen species metabolic process	IEA	biological process
GO:0060710	chorio-allantoic fusion	IEA	biological process
GO:0060591	chondroblast differentiation	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0030198	extracellular matrix organization	IEA	biological process
GO:0010518	positive regulation of phospholipase activity	IEA	biological process
GO:0007155	cell adhesion	IEA	biological process
GO:0005178	integrin binding	IEA	molecular function
GO:0003281	ventricular septum development	IEA	biological process
GO:0003278	apoptotic process involved in heart morphogenesis	IEA	biological process
GO:0003181	atrioventricular valve morphogenesis	IEA	biological process
GO:0002041	intussusceptive angiogenesis	IEA	biological process
GO:0030501	positive regulation of bone mineralization	IDA	biological process
GO:0030335	positive regulation of cell migration	IDA	biological process
GO:0033690	positive regulation of osteoblast proliferation	IDA	biological process
GO:0044319	wound healing, spreading of cells	IDA	biological process
GO:0045669	positive regulation of osteoblast differentiation	IDA	biological process
GO:0070372	regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0001934	positive regulation of protein phosphorylation	IDA	biological process
GO:0045860	positive regulation of protein kinase activity	IDA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	biological process
GO:0030513	positive regulation of BMP signaling pathway	IGI	biological process
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospadias	MIK: 17437852
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17437852	Hypospadias			2 (1 case, 1 control)	Male infertility
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
24778562	Hypospadias			13 (5 controls, 8 cases)	Male infertility	Microarray