• Gene id: 347736

Gene Summary

• Gene Symbol: NME9   Gene   UCSC   Ensembl
• Aliases: NM23-H9, NXL2, TXL-2, TXL2, TXNDC6
• Gene name: NME/NM23 family member 9
• Alternate names: thioredoxin domain-containing protein 6, NME gene family member 9, thioredoxin-like protein 2,
• Gene location: 3q22.3 (138331784: 138261435)     Exons: 17     NC_000003.12
• OMIM: 618584

Protein Summary

• Protein general information: Q86XW9  
  • Name: Thioredoxin domain containing protein 6 (Thioredoxin like protein 2) (Txl 2)
  • Length: 330  
  • Mass: 36856
  • Tissue specificity: Detected at very low levels in testis, lung and brain. {ECO
• Sequence:

  MGSRKKEIALQVNISTQELWEEMLSSKGLTVVDVYQGWCGPCKPVVSLFQKMRIEVGLDLLHFALAEADRLDVLE
  KYRGKCEPTFLFYAGGELVAVVRGANAPLLQKTILDQLEAEKKVLAEGRERKVIKDEALSDEDECVSHGKNNGED
  EDMVSSERTCTLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQHKAGEEAFEKLVHHMCSG
  PSHLLILTRTEGFEDVVTTWRTVMGPRDPNVARREQPESLRAQYGTEMPFNAVHGSRDREDADRELALLFPSLKF
  SDKDTEAPQGGEAEATAGPTEALCFPEDVD

• Structural information:
  • Protein Domains: (11..11-)
    (/note="Thioredoxin"-)
  • Interpro: IPR034907  IPR036850  IPR001564  IPR036249  IPR017937   IPR013766  
  • Prosite: PS00194
• Other Databases: GeneCards:  NME9  Malacards:  NME9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006228	UTP biosynthetic process	IEA	biological process
GO:0006241	CTP biosynthetic process	IEA	biological process
GO:0004550	nucleoside diphosphate kinase activity	IEA	molecular function
GO:0006165	nucleoside diphosphate phosphorylation	IEA	biological process
GO:0006183	GTP biosynthetic process	IEA	biological process
GO:0045454	cell redox homeostasis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881