• Gene id: 3455

Gene Summary

• Gene Symbol: IFNAR2   Gene   UCSC   Ensembl
• Aliases: IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45
• Gene name: interferon alpha and beta receptor subunit 2
• Alternate names: interferon alpha/beta receptor 2, IFN-R-2, IFN-alpha/beta receptor 2, human interferon alpha/beta receptor, interferon (alpha, beta and omega) receptor 2, interferon alpha binding protein, interferon receptor, interferon-alpha/beta receptor beta chain, ty,
• Gene location: 21q22.11 (33229894: 33264512)     Exons: 10     NC_000021.9
• Gene summary(Entrez): The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several prote
• OMIM: 602376

Protein Summary

• Protein general information: P48551  
  • Name: Interferon alpha/beta receptor 2 (IFN R 2) (IFN alpha binding protein) (IFN alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
  • Length: 515  
  • Mass: 57,759
• Sequence:

  MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSK
  PEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINV
  MVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPL
  KCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
  MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDV
  ELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLS
  SHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR

• Structural information:
  • Interpro: IPR003961  IPR036116  IPR013783  IPR015373  
  • PDB: 1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
  • PDBsum: 1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
  • DIP: 945
  • STRING: ENSP00000343957
• Other Databases: GeneCards:  IFNAR2  Malacards:  IFNAR2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004905	type I interferon receptor activity	IDA	molecular function
GO:0004905	type I interferon receptor activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005622	intracellular	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007259	JAK-STAT cascade	TAS	biological process
GO:0008283	cell proliferation	IEA	biological process
GO:0009615	response to virus	TAS	biological process
GO:0019901	protein kinase binding	IPI	molecular function
GO:0019962	type I interferon binding	IPI	molecular function
GO:0035455	response to interferon-alpha	IDA	biological process
GO:0042015	interleukin-20 binding	IBA	molecular function
GO:0060337	type I interferon signaling pathway	IDA	biological process
GO:0060337	type I interferon signaling pathway	TAS	biological process
GO:0060338	regulation of type I interferon-mediated signaling pathway	TAS	biological process
GO:0004905	type I interferon receptor activity	IEA	molecular function
GO:0004905	type I interferon receptor activity	IDA	molecular function
GO:0004905	type I interferon receptor activity	IDA	molecular function
GO:0004905	type I interferon receptor activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005622	intracellular	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007259	JAK-STAT cascade	TAS	biological process
GO:0008283	cell proliferation	IEA	biological process
GO:0009615	response to virus	TAS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0019901	protein kinase binding	IPI	molecular function
GO:0019962	type I interferon binding	IPI	molecular function
GO:0035455	response to interferon-alpha	IDA	biological process
GO:0042015	interleukin-20 binding	IBA	molecular function
GO:0060337	type I interferon signaling pathway	IEA	biological process
GO:0060337	type I interferon signaling pathway	IDA	biological process
GO:0060337	type I interferon signaling pathway	TAS	biological process
GO:0060338	regulation of type I interferon-mediated signaling pathway	TAS	biological process
GO:0004905	type I interferon receptor activity	IDA	molecular function
GO:0004905	type I interferon receptor activity	IDA	molecular function
GO:0004905	type I interferon receptor activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007259	JAK-STAT cascade	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0019901	protein kinase binding	IPI	molecular function
GO:0019962	type I interferon binding	IPI	molecular function
GO:0035455	response to interferon-alpha	IDA	biological process
GO:0042015	interleukin-20 binding	IBA	molecular function
GO:0060337	type I interferon signaling pathway	IDA	biological process
GO:0060337	type I interferon signaling pathway	TAS	biological process
GO:0060338	regulation of type I interferon-mediated signaling pathway	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04217	Necroptosis
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04380	Osteoclast differentiation
hsa05200	Pathways in cancer
hsa05162	Measles
hsa05164	Influenza A
hsa05160	Hepatitis C
hsa05168	Herpes simplex virus 1 infection
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa05169	Epstein-Barr virus infection
hsa05165	Human papillomavirus infection

Diseases

Associated diseases	References
Cancer	GAD: 18676680
Cancer (lung)	GAD: 18676680
Cancer (bladder)	GAD: 19692168
Cancer (Hepatocellular)	GAD: 19817957
Cancer (esophageal)	GAD: 20453000
Cancer (myeloid leukemia)	GAD: 20065083
Atherosclerosis	GAD: 20485444
Behcet's disease	GAD: 19796549
Multiple sclerosis	GAD: 12618863
Bone diseases	GAD: 19453261
Male factor infertility	MIK: 10813851
Chronic obstructive pulmonary disease (COPD)	GAD: 19625176
Male infertility	MIK: 10813851

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
10813851	Male infertility				Male infertility