• Gene id: 344558

Gene Summary

• Gene Symbol: SH3RF3   Gene   UCSC   Ensembl
• Aliases: POSH2, SH3MD4
• Gene name: SH3 domain containing ring finger 3
• Alternate names: E3 ubiquitin-protein ligase SH3RF3, SH3 domain-containing RING finger protein 3, SH3 multiple domains 4, plenty of SH3s-2,
• Gene location: 2q13 (109129204: 109504634)     Exons: 12     NC_000002.12

Protein Summary

• Protein general information: Q8TEJ3  
  • Name: E3 ubiquitin protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain containing RING finger protein 3) (SH3 multiple domains protein 4)
  • Length: 882  
  • Mass: 92776
• Sequence:

  MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVCLERLDTTAKVLPCQH
  TFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLA
  GGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRR
  KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEG
  MLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKN
  TKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAA
  SVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSR
  VPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTA
  SQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAI
  TPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQV
  AVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPR
  ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF

• Structural information:
  • Protein Domains: (194..25-)
    (/note="SH3-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
    (256..31-)
    (/note="SH3-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
    (464..52-)
    (/note="SH3-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
    (-)
  • Interpro: IPR036028  IPR001452  IPR028502  IPR035816  IPR035612   IPR001841  IPR013083  IPR017907  
  • Prosite: PS50002 PS00518 PS50089
  • CDD: cd11925 cd11785
  • DIP: 43763
  • STRING: ENSP00000309186
• Other Databases: GeneCards:  SH3RF3  Malacards:  SH3RF3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061630	ubiquitin protein ligase activity	IMP	molecular function
GO:0046330	positive regulation of JNK cascade	IMP	biological process
GO:0051865	protein autoubiquitination	IMP	biological process
GO:0046328	regulation of JNK cascade	IEA	biological process
GO:0006915	apoptotic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016567	protein ubiquitination	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq