• Gene id: 3440

Gene Summary

• Gene Symbol: IFNA2   Gene   UCSC   Ensembl
• Aliases: IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A
• Gene name: interferon alpha 2
• Alternate names: interferon alpha-2, alpha-2a interferon, interferon alpha 2a, interferon alpha 2b, interferon alpha A,
• Gene location: 9p21.3 (21385397: 21384254)     Exons: 1     NC_000009.12
• Gene summary(Entrez): This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and
• OMIM: 602767

SNPs

rs3021522

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000012.12   g.2799979C>G
NC_000012.11   g.2909145C>G|SEQ=[C/G]|GENE=FKBP4
ITFG2-AS1   283440

Protein Summary

• Protein general information: P01563  
  • Name: Interferon alpha 2 (IFN alpha 2) (Interferon alpha A) (LeIF A)
  • Length: 188  
  • Mass: 21550
• Sequence:

  MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFGFPQEEFGNQFQKAET
  IPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRIT
  LYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE

• Structural information:
  • Interpro: IPR009079  IPR000471  
  • Prosite: PS00252
  • CDD: cd00095
  • PDB: 1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
  • PDBsum: 1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
  • DIP: 481
  • STRING: ENSP00000369554
• Other Databases: GeneCards:  IFNA2  Malacards:  IFNA2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042100	B cell proliferation	IBA	biological process
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	IBA	biological process
GO:0005132	type I interferon receptor binding	IBA	molecular function
GO:0002323	natural killer cell activation involved in immune response	IBA	biological process
GO:0002250	adaptive immune response	IBA	biological process
GO:0043330	response to exogenous dsRNA	IBA	biological process
GO:0030183	B cell differentiation	IBA	biological process
GO:0019221	cytokine-mediated signaling pathway	IBA	biological process
GO:0006959	humoral immune response	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0005125	cytokine activity	IBA	molecular function
GO:0002286	T cell activation involved in immune response	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005126	cytokine receptor binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0006952	defense response	IEA	biological process
GO:0051607	defense response to virus	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0005132	type I interferon receptor binding	TAS	molecular function
GO:0006915	apoptotic process	TAS	biological process
GO:0006954	inflammatory response	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IMP	biological process
GO:0042327	positive regulation of phosphorylation	IMP	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0007596	blood coagulation	TAS	biological process
GO:0060337	type I interferon signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0051607	defense response to virus	IDA	biological process
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	biological process
GO:0046597	negative regulation of viral entry into host cell	IDA	biological process
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	colocalizes with
GO:0005576	extracellular region	IEA	cellular component
GO:2000663	negative regulation of interleukin-5 secretion	IDA	biological process
GO:2000552	negative regulation of T-helper 2 cell cytokine production	IDA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IDA	biological process
GO:0045581	negative regulation of T cell differentiation	IDA	biological process
GO:2000666	negative regulation of interleukin-13 secretion	IDA	biological process
GO:0010629	negative regulation of gene expression	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa05168	Herpes simplex virus 1 infection
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04060	Cytokine-cytokine receptor interaction
hsa05163	Human cytomegalovirus infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05169	Epstein-Barr virus infection
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa04621	NOD-like receptor signaling pathway
hsa05152	Tuberculosis
hsa04217	Necroptosis
hsa04630	JAK-STAT signaling pathway
hsa05164	Influenza A
hsa05161	Hepatitis B
hsa05160	Hepatitis C
hsa05162	Measles
hsa04650	Natural killer cell mediated cytotoxicity
hsa04620	Toll-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa05320	Autoimmune thyroid disease

Diseases

Associated diseases	References
Non-alcoholic fatty liver disease	PMID:30602382
hepatocellular carcinoma	PMID:29080269
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881