• Gene id: 3421

Gene Summary

• Gene Symbol: IDH3G   Gene   UCSC   Ensembl
• Aliases: H-IDHG
• Gene name: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
• Alternate names: isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, IDH-gamma, NAD (H)-specific isocitrate dehydrogenase gamma subunit, NAD(+)-specific ICDH subunit gamma, NAD+-specific ICDH, isocitrate dehydrogenase (NAD(+)) 3 gamma, isocitrate dehydrogenase 3 (NAD(+,
• Gene location: Xq28 (153794374: 153785767)     Exons: 12     NC_000023.11
• Gene summary(Entrez): Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases
• OMIM: 300089

Protein Summary

• Protein general information: P51553  
  • Name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+) specific ICDH subunit gamma)
  • Length: 393  
  • Mass: 42794
• Sequence:

  MALKVATVAGSAAKAVLGPALLCRPWEVLGAHEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKS
  VFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKS
  LPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIM
  KLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG
  HVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEA
  IQDVIRHIRVINGRAVEA

• Structural information:
  • Interpro: IPR019818  IPR004434  IPR024084  
  • Prosite: PS00470
  • PDB: 5GRE 5GRF 5GRH 5GRI 5GRL 5YVT
  • PDBsum: 5GRE 5GRF 5GRH 5GRI 5GRL 5YVT
  • STRING: ENSP00000217901
• Other Databases: GeneCards:  IDH3G  Malacards:  IDH3G

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006099	tricarboxylic acid cycle	IBA	biological process
GO:0004449	isocitrate dehydrogenase (NAD+) activity	IBA	molecular function
GO:0006102	isocitrate metabolic process	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0000287	magnesium ion binding	IEA	molecular function
GO:0004449	isocitrate dehydrogenase (NAD+) activity	IEA	molecular function
GO:0006099	tricarboxylic acid cycle	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	molecular function
GO:0051287	NAD binding	IEA	molecular function
GO:0006099	tricarboxylic acid cycle	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004449	isocitrate dehydrogenase (NAD+) activity	TAS	molecular function
GO:0005975	carbohydrate metabolic process	NAS	biological process
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006099	tricarboxylic acid cycle	TAS	biological process
GO:0005739	mitochondrion	IDA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0004449	isocitrate dehydrogenase (NAD+) activity	ISS	molecular function
GO:0006102	isocitrate metabolic process	ISS	biological process
GO:0005739	mitochondrion	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa01230	Biosynthesis of amino acids
hsa00020	Citrate cycle
hsa01210	2-Oxocarboxylic acid metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq