• Gene id: 341947

Gene Summary

• Gene Symbol: COX8C   Gene   UCSC   Ensembl
• Aliases: COX8-3
• Gene name: cytochrome c oxidase subunit 8C
• Alternate names: cytochrome c oxidase subunit 8C, mitochondrial, COX VIII-3, cytochrome c oxidase polypeptide 8, cytochrome c oxidase polypeptide VIII, cytochrome c oxidase subunit 8-3, cytochrome c oxidase subunit VIII, cytochrome c oxidase subunit VIIIC,
• Gene location: 14q32.12 (93347181: 93348355)     Exons: 2     NC_000014.9

Protein Summary

• Protein general information: Q7Z4L0  
  • Name: Cytochrome c oxidase subunit 8C, mitochondrial (Cytochrome c oxidase polypeptide 8 isoform 3) (Cytochrome c oxidase polypeptide VIII isoform 3) (COX VIII 3) (Cytochrome c oxidase subunit 8 3) (COX8 3) (Cytochrome c oxidase subunit VIIIC)
  • Length: 72  
  • Mass: 8129
  • Tissue specificity: It is not yet known where COX8C is expressed.
• Sequence:

  MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFRRN

• Structural information:
  • Interpro: IPR003205  IPR036548  
  • STRING: ENSP00000340568
• Other Databases: GeneCards:  COX8C  Malacards:  COX8C

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005739	mitochondrion	IBA	cellular component
GO:0045277	respiratory chain complex IV	IBA	cellular component
GO:0004129	cytochrome-c oxidase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:1902600	proton transmembrane transport	IEA	biological process
GO:0022900	electron transport chain	IEA	biological process
GO:0006119	oxidative phosphorylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05010	Alzheimer disease
hsa05016	Huntington disease
hsa05012	Parkinson disease
hsa04714	Thermogenesis
hsa00190	Oxidative phosphorylation
hsa04932	Non-alcoholic fatty liver disease
hsa04260	Cardiac muscle contraction

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881