• Gene id: 3416

Gene Summary

• Gene Symbol: IDE   Gene   UCSC   Ensembl
• Aliases: INSULYSIN
• Gene name: insulin degrading enzyme
• Alternate names: insulin-degrading enzyme, Abeta-degrading protease, insulin protease, insulinase,
• Gene location: 10q23.33 (151254733: 151267478)     Exons: 10     NC_000001.11
• Gene summary(Entrez): This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and k
• OMIM: 146680

Protein Summary

• Protein general information: P14735  
  • Name: Insulin degrading enzyme (EC 3.4.24.56) (Abeta degrading protease) (Insulin protease) (Insulinase) (Insulysin)
  • Length: 1019  
  • Mass: 117968
  • Tissue specificity: Detected in brain and in cerebrospinal fluid (at protein level). {ECO
• Sequence:

  MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKV
  LLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYY
  FDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYT
  LETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
  LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFII
  NVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL
  TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP
  TKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
  KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRA
  EQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLI
  EHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRT
  KEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
  SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQ
  NDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL

• Structural information:
  • Interpro: IPR011249  IPR011765  IPR001431  IPR007863  IPR032632  
  • Prosite: PS00143
  • PDB: 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3
  • PDBsum: 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3
  • DIP: 55771
  • STRING: ENSP00000265986
• Other Databases: GeneCards:  IDE  Malacards:  IDE

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006508	proteolysis	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009897	external side of plasma membrane	IDA	cellular component
GO:0004222	metalloendopeptidase activity	TAS	molecular function
GO:0005615	extracellular space	TAS	cellular component
GO:0005615	extracellular space	ISS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	biological process
GO:0150094	amyloid-beta clearance by cellular catabolic process	ISS	biological process
GO:0016323	basolateral plasma membrane	IMP	cellular component
GO:0070062	extracellular exosome	ISS	cellular component
GO:0005777	peroxisome	TAS	cellular component
GO:0045732	positive regulation of protein catabolic process	TAS	biological process
GO:0009986	cell surface	ISS	cellular component
GO:1903715	regulation of aerobic respiration	IGI	biological process
GO:0030163	protein catabolic process	ISS	biological process
GO:0097242	amyloid-beta clearance	ISS	biological process
GO:0097242	amyloid-beta clearance	IMP	biological process
GO:0097242	amyloid-beta clearance	IMP	biological process
GO:0097242	amyloid-beta clearance	ISS	biological process
GO:0097242	amyloid-beta clearance	ISS	biological process
GO:0050435	amyloid-beta metabolic process	IBA	biological process
GO:0051603	proteolysis involved in cellular protein catabolic process	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0005782	peroxisomal matrix	IBA	cellular component
GO:0042447	hormone catabolic process	IBA	biological process
GO:0043171	peptide catabolic process	IBA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0050435	amyloid-beta metabolic process	IDA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0042447	hormone catabolic process	IDA	biological process
GO:1901143	insulin catabolic process	IDA	biological process
GO:0043171	peptide catabolic process	IDA	biological process
GO:0004175	endopeptidase activity	IDA	molecular function
GO:0044257	cellular protein catabolic process	IMP	biological process
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	IMP	biological process
GO:0140036	ubiquitin-dependent protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004222	metalloendopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008152	metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0001618	virus receptor activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005782	peroxisomal matrix	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006625	protein targeting to peroxisome	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0051603	proteolysis involved in cellular protein catabolic process	IEA	biological process
GO:0050435	amyloid-beta metabolic process	IEA	biological process
GO:0044257	cellular protein catabolic process	IEA	biological process
GO:0031626	beta-endorphin binding	IEA	molecular function
GO:0031597	cytosolic proteasome complex	IEA	cellular component
GO:0017046	peptide hormone binding	IEA	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0005829	cytosol	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0150094	amyloid-beta clearance by cellular catabolic process	IEA	biological process
GO:0097242	amyloid-beta clearance	IEA	biological process
GO:0045861	negative regulation of proteolysis	IEA	biological process
GO:0044877	protein-containing complex binding	IEA	molecular function
GO:0043559	insulin binding	IEA	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0042447	hormone catabolic process	IEA	biological process
GO:0016887	ATPase activity	IEA	molecular function
GO:0009986	cell surface	IEA	cellular component
GO:0005782	peroxisomal matrix	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0004222	metalloendopeptidase activity	IEA	molecular function
GO:0001540	amyloid-beta binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0046718	viral entry into host cell	IEA	biological process
GO:0050435	amyloid-beta metabolic process	IDA	biological process
GO:0032092	positive regulation of protein binding	IDA	biological process
GO:0008340	determination of adult lifespan	IDA	biological process
GO:0006508	proteolysis	IDA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:1901143	insulin catabolic process	IDA	biological process
GO:1901143	insulin catabolic process	IDA	biological process
GO:0010992	ubiquitin recycling	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	NOT|cellular component
GO:0005524	ATP binding	IDA	molecular function
GO:0051603	proteolysis involved in cellular protein catabolic process	IDA	biological process
GO:0050435	amyloid-beta metabolic process	IDA	biological process
GO:0008270	zinc ion binding	IDA	molecular function
GO:0006508	proteolysis	IDA	biological process
GO:1901142	insulin metabolic process	IDA	biological process
GO:0043559	insulin binding	IDA	molecular function
GO:0010815	bradykinin catabolic process	IDA	biological process
GO:0010815	bradykinin catabolic process	IDA	biological process
GO:0005777	peroxisome	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0004222	metalloendopeptidase activity	IDA	molecular function
GO:0004222	metalloendopeptidase activity	IDA	molecular function
GO:0043559	insulin binding	IPI	molecular function
GO:0008286	insulin receptor signaling pathway	NAS	biological process
GO:0042277	peptide binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05010	Alzheimer disease

Diseases

Associated diseases	References
Diabetic encephalopathy	PMID:27306699
Alzheimer's disease	PMID:28164769
Alzheimer's disease	PMID:26963025
type 2 diabetes mellitus	PMID:12765971
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R