• Gene id: 341019

Gene Summary

• Gene Symbol: DCDC1   Gene   UCSC   Ensembl
• Aliases: DCDC5
• Gene name: doublecortin domain containing 1
• Alternate names: doublecortin domain-containing protein 1, doublecortin domain-containing 5 protein, doublecortin domain-containing protein 5,
• Gene location: 11p13 (31369809: 30863602)     Exons: 51     NC_000011.10
• Gene summary(Entrez): This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This g
• OMIM: 601746

Protein Summary

• Protein general information: M0R2J8  
  • Name: Doublecortin domain containing protein 1 (Doublecortin domain containing 5 protein)
  • Length: 1783  
  • Mass: 200591
• Sequence:

  MAKTGAEDHREALSQSSLSLLTEAMEVLQQSSPEGTLDGNTVNPIYKYILNDLPREFMSSQAKAVIKTTDDYLQS
  QFGPNRLVHSAAVSEGSGLQDCSTHQTASDHSHDEISDLDSYKSNSKNNSCSISASKRNRPVSAPVGQLRVAEFS
  SLKFQSARNWQKLSQRHKLQPRVIKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALE
  PEDIPHEADVYVSTGEPFLNPFKKIKDHLLLIKKVTWTMNGLMLPTDIKRRKTKPVLSIRMKKLTERTSVRILFF
  KNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSKG
  EGFSPSGAKMYIQGVLLALYQRLKSAKKYYKQLNLVMNEQKEKITEKVILSMTAKEHHKEQEEVSRLIDELQTAI
  KSNIGHLCKLGPQLQAEQEQFSSYVYQHIKSLPANTLVPGGLQLKVFENGKNTGEISVGISKKDLGSDSPIQTDH
  MMERLLLKIHQRLQGSSINPPGLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYGRAYRSPLNLALGLTFDRVSA
  FARGDIMVAYKTFLDPNAVLLPGCGNWEVCEGFPINFNCTSQQIPDQFEKVDLENHFLQNKVDPNIVLHASVSIG
  KWSFSGSEASSRSQIAPSILWPVASVWLITKTGMILSRAITQGCLAIGHPIRVKAAEGTSLEGYKLILQKRHSGD
  DSQKWVFGTDGCIYSKAYPQFVLTYLEELNAQVDVTQTEYHIHHGAWTTAHQEHGRNLAEEVLQESASNLGLKQL
  PEPSDTHLMPEGSLEETGELTVALVRKLEEKHPKASAQRWAIKHEGTSKPGQWKHSRVENPLWNKLTYMWPVLPS
  GQLNEEFDWPIQGLLVPSSPPMKKPICKTTEPYAPVRLRVLQNGEKNKNRSVTILGPDISPGRKTQCTEILNLPS
  AARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDLSIAQQKKQIFLRNLESDIAKIQIFCSTHKIEALVLEV
  QSDIVSGSKLAVHKPVAIFGEEKQVTEPEEKQMQEDPLTTENASSEILDSHVRAHLRMKACHTLPRYAWQETSHD
  FDEDDSLPKKTEKGLFENVEPQKKHSCSPKHSKLHKHCHQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLV
  EKKSDGSHQRWIHQEDSRTFHLVSNPDLVLAVSMTKTRNEVCGYPVIVQKYKPYNNGAANQKWHYMKNIKALVAF
  HSTALDKEITSANYAGVCTSSVIKEENIDQPGYCYLSPDGKRKTMLCLACGQSMRTEKGLKQLLPGVPFLCISGT
  KTQKPFLQGPFKVISVAEVDLSCDKAEKTLSYYQARLLSLRMKTCTQAASHSGMAATHQKAVKIIAYKNGDGYRN
  GKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDLVLWALDESFLQRDSEKQKQDAAPVGKEQIIVE
  KNPRMKVKNRLFAKSVTSDSLDGIDKSLLTLILRNPIAIWVSCGEPFLPPNALQKAEKLEKQNWLKKDRILADLD
  TMRHKMRQLKGRRVAACQPATMVPTKSPVQPVVVEGGWTEQTQQEIKLMELIRHTEAHLSEIQEMESKINFPIAT
  KRIAVKPSNLYKQPNTKRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIER
  DMVICVSMGHGFKTPKELKQLMEIRANYARIRRQQGPQATDIVVSPSTKLLSLAHLHN

• Structural information:
  • Protein Domains: (168..25-)
    (/note="Doublecortin-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00072-)
    (702..80-)
    lectin (/note="Ricin-B-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00174-)
    (925..101-)
    (/note="Doublecortin-2)
    (/evidence="ECO:000-)
  • Interpro: IPR003533  IPR036572  IPR035992  IPR000772  
  • Prosite: PS50309 PS50231
  • CDD: cd00161
  • STRING: ENSP00000385936
• Other Databases: GeneCards:  DCDC1  Malacards:  DCDC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0090543	Flemming body	IDA	cellular component
GO:0008017	microtubule binding	IDA	molecular function
GO:0072686	mitotic spindle	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:1902412	regulation of mitotic cytokinesis	IMP	biological process
GO:0008017	microtubule binding	IEA	molecular function
GO:1902412	regulation of mitotic cytokinesis	IEA	biological process
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0090543	Flemming body	IEA	cellular component
GO:0030496	midbody	IEA	cellular component
GO:0005819	spindle	IEA	cellular component
GO:0090543	Flemming body	IDA	cellular component
GO:0008017	microtubule binding	IDA	molecular function
GO:0072686	mitotic spindle	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:1902412	regulation of mitotic cytokinesis	IMP	biological process
GO:0008017	microtubule binding	IEA	molecular function
GO:1902412	regulation of mitotic cytokinesis	IEA	biological process
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0090543	Flemming body	IEA	cellular component
GO:0030496	midbody	IEA	cellular component
GO:0005819	spindle	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881