• Gene id: 339398

Gene Summary

• Gene Symbol: LINGO4   Gene   UCSC   Ensembl
• Aliases: DAAT9248, LRRN6D, PRO34002
• Gene name: leucine rich repeat and Ig domain containing 4
• Alternate names: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4, leucine-rich repeat neuronal protein 6D,
• Gene location: 1q21.3 (24242673: 24239639)     Exons: 6     NC_000014.9
• OMIM: 609794

Protein Summary

• Protein general information: Q6UY18  
  • Name: Leucine rich repeat and immunoglobulin like domain containing nogo receptor interacting protein 4 (Leucine rich repeat neuronal protein 6D)
  • Length: 593  
  • Mass: 63774
• Sequence:

  MDAATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGL
  QQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG
  AFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALR
  GLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV
  RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRH
  LDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRP
  HGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGIPGPF
  FLDSRGVAMVLAVGFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGGNRVTAKLF

• Structural information:
  • Protein Domains: (29..6-)
    (/note="LRRNT-)
    (358..41-)
    (/note="LRRCT-)
    (412..50-)
    (/note="Ig-like-C2-type")
  • Interpro: IPR000483  IPR007110  IPR036179  IPR013783  IPR013098   IPR003599  IPR003598  IPR001611  IPR003591  IPR032675  IPR000372  
  • Prosite: PS50835 PS51450
  • STRING: ENSP00000357810
• Other Databases: GeneCards:  LINGO4  Malacards:  LINGO4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0031012	extracellular matrix	IBA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)