• Gene id: 339287

Gene Summary

• Gene Symbol: MSL1   Gene   UCSC   Ensembl
• Aliases: MSL-1
• Gene name: MSL complex subunit 1
• Alternate names: male-specific lethal 1 homolog, MSL1-like 1, male specific lethal 1 homolog, male-specific lethal 1-like 1, male-specific lethal-1 homolog 1,
• Gene location: 17q21.1 (40121970: 40136916)     Exons: 9     NC_000017.11
• OMIM: 614801

Protein Summary

• Protein general information: Q68DK7  
  • Name: Male specific lethal 1 homolog (MSL 1) (Male specific lethal 1 like 1) (MSL1 like 1) (Male specific lethal 1 homolog 1)
  • Length: 614  
  • Mass: 67128
• Sequence:

  MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDEPGAAEAHFLPRHRKLKEPGPPLASSQGGSPAPSPAGCG
  GKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPAAAGAGCSPRPKYQAVLPIQTGSLVAAAKEPT
  PWAGDKGGAASPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSMRKSPLGGGGGSGASSQAACLKQI
  LLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKI
  KLECQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSET
  VCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRESS
  PKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKLELDEKRRKRWDIQRI
  REQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRL
  EIQKKQTPHRTCRK

• Structural information:
  • Interpro: IPR026711  IPR031840  IPR029332  
  • PDB: 4B7Y 4B86 4DNC
  • PDBsum: 4B7Y 4B86 4DNC
  • DIP: 56862
  • STRING: ENSP00000462945
• Other Databases: GeneCards:  MSL1  Malacards:  MSL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003682	chromatin binding	IBA	molecular function
GO:0072487	MSL complex	IBA	cellular component
GO:0043984	histone H4-K16 acetylation	IBA	biological process
GO:0072487	MSL complex	IDA	cellular component
GO:0043984	histone H4-K16 acetylation	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016607	nuclear speck	ISS	cellular component
GO:0043984	histone H4-K16 acetylation	IEA	biological process
GO:0072487	MSL complex	IEA	cellular component
GO:0006325	chromatin organization	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016607	nuclear speck	IEA	cellular component
GO:0043984	histone H4-K16 acetylation	IEA	biological process
GO:0016607	nuclear speck	IEA	cellular component
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq