• Gene id: 338599

Gene Summary

• Gene Symbol: DUPD1   Gene   UCSC   Ensembl
• Aliases: DUSP27, FMDSP
• Gene name: dual specificity phosphatase and pro isomerase domain containing 1
• Alternate names: dual specificity phosphatase DUPD1, atypical dual-specific protein phosphatase, dual specificity phosphatase 27,
• Gene location: 10q22.2 (75073826: 75026426)     Exons: 7     NC_000010.11
• OMIM: 615126

Protein Summary

• Protein general information: Q68J44  
  • Name: Dual specificity phosphatase DUPD1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase 27)
  • Length: 220  
  • Mass: 25336
• Sequence:

  MTSGEVKTSLKNAYSSAKRLSPKMEEEGEEEDYCTPGAFELERLFWKGSPQYTHVNEVWPKLYIGDEATALDRYR
  LQKAGFTHVLNAAHGRWNVDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMG
  RSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQRRRSQRQDGEEEDGREL

• Structural information:
  • Protein Domains: (54..20-)
    (/note="Tyrosine-protein-phosphatase")
  • Interpro: IPR020417  IPR020405  IPR000340  IPR029021  IPR016130   IPR000387  IPR020422  
  • Prosite: PS00383 PS50056 PS50054
  • PDB: 2Y96
  • PDBsum: 2Y96
  • STRING: ENSP00000340609
• Other Databases: GeneCards:  DUPD1  Malacards:  DUPD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006470	protein dephosphorylation	IDA	biological process
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IDA	molecular function
GO:0032991	protein-containing complex	IDA	cellular component
GO:0042803	protein homodimerization activity	IDA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq