• Gene id: 338442

Gene Summary

• Gene Symbol: HCAR2   Gene   UCSC   Ensembl
• Aliases: GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g
• Gene name: hydroxycarboxylic acid receptor 2
• Alternate names: hydroxycarboxylic acid receptor 2, G protein-coupled receptor HM74a, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, hydroxy-carboxylic acid receptor 2, niacin receptor 1, nicotinic acid receptor,
• Gene location: 12q24.31 (122703356: 122701292)     Exons: 1     NC_000012.12
• OMIM: 612974

Protein Summary

• Protein general information: Q8TDS4  
  • Name: Hydroxycarboxylic acid receptor 2 (G protein coupled receptor 109A) (G protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)
  • Length: 363  
  • Mass: 41850
  • Tissue specificity: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO
• Sequence:

  MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFL
  LIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCL
  LWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAK
  IKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
  FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP

• Structural information:
  • Interpro: IPR000276  IPR017452  IPR028017  
  • Prosite: PS00237 PS50262
  • STRING: ENSP00000375066
• Other Databases: GeneCards:  HCAR2  Malacards:  HCAR2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0006915	apoptotic process	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0030054	cell junction	IDA	cellular component
GO:0033031	positive regulation of neutrophil apoptotic process	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0001781	neutrophil apoptotic process	IDA	biological process
GO:0070553	nicotinic acid receptor activity	ISS	molecular function
GO:0070165	positive regulation of adiponectin secretion	ISS	biological process
GO:0050995	negative regulation of lipid catabolic process	ISS	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0006915	apoptotic process	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0030054	cell junction	IDA	cellular component
GO:0033031	positive regulation of neutrophil apoptotic process	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0001781	neutrophil apoptotic process	IDA	biological process
GO:0070553	nicotinic acid receptor activity	ISS	molecular function
GO:0070165	positive regulation of adiponectin secretion	ISS	biological process
GO:0050995	negative regulation of lipid catabolic process	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04024	cAMP signaling pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881