• Gene id: 332

Gene Summary

• Gene Symbol: BIRC5   Gene   UCSC   Ensembl
• Aliases: API4, EPR-1
• Gene name: baculoviral IAP repeat containing 5
• Alternate names: baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, apoptosis inhibitor survivin, survivin variant 3 alpha,
• Gene location: 17q25.3 (78214195: 78225634)     Exons: 6     NC_000017.11
• Gene summary(Entrez): This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes pro
• OMIM: 603352

Protein Summary

• Protein general information: O15392  
  • Name: Baculoviral IAP repeat containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
  • Length: 142  
  • Mass: 16,389
  • Tissue specificity: Skeletal muscle specific.
• Sequence:

  MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIE
  EHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD

• Structural information:
  • Interpro: IPR001370  
  • Prosite: PS50143
  • CDD: cd00022
  • PDB: 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
  • PDBsum: 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
  • DIP: 34662
• Other Databases: GeneCards:  BIRC5  Malacards:  BIRC5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000086	G2/M transition of mitotic cell cycle	IDA	biological process
GO:0000228	nuclear chromosome	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000777	condensed chromosome kinetochore	IDA	cellular component
GO:0000910	cytokinesis	IMP	biological process
GO:0004842	ubiquitin-protein transferase activity	IBA	molecular function
GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005814	centriole	IDA	cellular component
GO:0005819	spindle	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005876	spindle microtubule	IDA	cellular component
GO:0005876	spindle microtubule	IDA	cellular component
GO:0005881	cytoplasmic microtubule	IDA	cellular component
GO:0006351	transcription, DNA-templated	IEA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0007062	sister chromatid cohesion	TAS	biological process
GO:0007067	mitotic nuclear division	TAS	biological process
GO:0008017	microtubule binding	TAS	molecular function
GO:0008017	microtubule binding	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0008270	zinc ion binding	NAS	molecular function
GO:0008284	positive regulation of cell proliferation	TAS	biological process
GO:0008536	Ran GTPase binding	IPI	molecular function
GO:0009966	regulation of signal transduction	IBA	biological process
GO:0015631	tubulin binding	IDA	molecular function
GO:0016567	protein ubiquitination	IEA	biological process
GO:0016925	protein sumoylation	TAS	biological process
GO:0019899	enzyme binding	IPI	molecular function
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0031021	interphase microtubule organizing center	IDA	cellular component
GO:0031503	protein complex localization	IMP	biological process
GO:0031536	positive regulation of exit from mitosis	IMP	biological process
GO:0031577	spindle checkpoint	IMP	biological process
GO:0032133	chromosome passenger complex	IPI	cellular component
GO:0032133	chromosome passenger complex	IPI	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0042981	regulation of apoptotic process	TAS	biological process
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	molecular function
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IMP	biological process
GO:0045931	positive regulation of mitotic cell cycle	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0048037	cofactor binding	IDA	molecular function
GO:0050897	cobalt ion binding	NAS	molecular function
GO:0051087	chaperone binding	IPI	molecular function
GO:0051301	cell division	IEA	biological process
GO:0051301	cell division	IMP	biological process
GO:0051303	establishment of chromosome localization	IMP	biological process
GO:0090307	mitotic spindle assembly	IBA	biological process
GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IBA	biological process
GO:0000086	G2/M transition of mitotic cell cycle	IDA	biological process
GO:0000228	nuclear chromosome	IDA	cellular component
GO:0000775	chromosome, centromeric region	IEA	cellular component
GO:0000775	chromosome, centromeric region	IEA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000776	kinetochore	IEA	cellular component
GO:0000777	condensed chromosome kinetochore	IEA	cellular component
GO:0000777	condensed chromosome kinetochore	IDA	cellular component
GO:0000910	cytokinesis	IMP	biological process
GO:0004842	ubiquitin-protein transferase activity	IBA	molecular function
GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005814	centriole	IDA	cellular component
GO:0005819	spindle	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005876	spindle microtubule	IDA	cellular component
GO:0005876	spindle microtubule	IDA	cellular component
GO:0005881	cytoplasmic microtubule	IDA	cellular component
GO:0006351	transcription, DNA-templated	IEA	biological process
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0006915	apoptotic process	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0007059	chromosome segregation	IEA	biological process
GO:0007062	sister chromatid cohesion	TAS	biological process
GO:0007067	mitotic nuclear division	IEA	biological process
GO:0007067	mitotic nuclear division	TAS	biological process
GO:0008017	microtubule binding	TAS	molecular function
GO:0008017	microtubule binding	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0008270	zinc ion binding	NAS	molecular function
GO:0008284	positive regulation of cell proliferation	TAS	biological process
GO:0008536	Ran GTPase binding	IPI	molecular function
GO:0009966	regulation of signal transduction	IBA	biological process
GO:0010466	negative regulation of peptidase activity	IEA	biological process
GO:0015631	tubulin binding	IDA	molecular function
GO:0016567	protein ubiquitination	IEA	biological process
GO:0016925	protein sumoylation	TAS	biological process
GO:0019899	enzyme binding	IPI	molecular function
GO:0030414	peptidase inhibitor activity	IEA	molecular function
GO:0030496	midbody	IEA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0031021	interphase microtubule organizing center	IDA	cellular component
GO:0031503	protein complex localization	IMP	biological process
GO:0031536	positive regulation of exit from mitosis	IMP	biological process
GO:0031577	spindle checkpoint	IMP	biological process
GO:0032133	chromosome passenger complex	IPI	cellular component
GO:0032133	chromosome passenger complex	IPI	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0042981	regulation of apoptotic process	TAS	biological process
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	molecular function
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IMP	biological process
GO:0045931	positive regulation of mitotic cell cycle	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0048037	cofactor binding	IDA	molecular function
GO:0050897	cobalt ion binding	NAS	molecular function
GO:0051087	chaperone binding	IPI	molecular function
GO:0051301	cell division	IEA	biological process
GO:0051301	cell division	IMP	biological process
GO:0051303	establishment of chromosome localization	IMP	biological process
GO:0090307	mitotic spindle assembly	IBA	biological process
GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IBA	biological process
GO:0000086	G2/M transition of mitotic cell cycle	IDA	biological process
GO:0000228	nuclear chromosome	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IDA	cellular component
GO:0000777	condensed chromosome kinetochore	IDA	cellular component
GO:0000910	cytokinesis	IMP	biological process
GO:0004842	ubiquitin-protein transferase activity	IBA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005814	centriole	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005876	spindle microtubule	IDA	cellular component
GO:0005876	spindle microtubule	IDA	cellular component
GO:0005881	cytoplasmic microtubule	IDA	cellular component
GO:0006468	protein phosphorylation	IDA	biological process
GO:0007062	sister chromatid cohesion	TAS	biological process
GO:0007067	mitotic nuclear division	TAS	biological process
GO:0008017	microtubule binding	TAS	molecular function
GO:0008017	microtubule binding	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0008270	zinc ion binding	NAS	molecular function
GO:0008284	positive regulation of cell proliferation	TAS	biological process
GO:0008536	Ran GTPase binding	IPI	molecular function
GO:0009966	regulation of signal transduction	IBA	biological process
GO:0015631	tubulin binding	IDA	molecular function
GO:0016925	protein sumoylation	TAS	biological process
GO:0019899	enzyme binding	IPI	molecular function
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0031021	interphase microtubule organizing center	IDA	cellular component
GO:0031503	protein complex localization	IMP	biological process
GO:0031536	positive regulation of exit from mitosis	IMP	biological process
GO:0031577	spindle checkpoint	IMP	biological process
GO:0032133	chromosome passenger complex	IPI	cellular component
GO:0032133	chromosome passenger complex	IPI	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0042981	regulation of apoptotic process	TAS	biological process
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	molecular function
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IMP	biological process
GO:0045931	positive regulation of mitotic cell cycle	IMP	biological process
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0048037	cofactor binding	IDA	molecular function
GO:0050897	cobalt ion binding	NAS	molecular function
GO:0051087	chaperone binding	IPI	molecular function
GO:0051301	cell division	IMP	biological process
GO:0051303	establishment of chromosome localization	IMP	biological process
GO:0090307	mitotic spindle assembly	IBA	biological process
GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IBA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04210	Apoptosis
hsa04215	Apoptosis - multiple species
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05161	Hepatitis B
hsa01524	Platinum drug resistance

Diseases

Associated diseases	References
Cancer	GAD: 20057973
Cancer (pancreatic)	GAD: 20357690
Cancer (transitional cell)	GAD: 19038421
Cancer (colorectal)	GAD: 18946675
Cancer (Adenocarcinoma)	GAD: 19352701
Cancer (head and neck)	GAD: 20819778
Cancer (leukemia)	GAD: 19074885
Cancer (cervical)	GAD: 16714396
Cancer (lung)	GAD: 20881643
Cancer (esophageal)	GAD: 20453000
Cancer (ovarian)	GAD: 20057973
Implantation failure	INFBASE: 23011643
Ovarian endometriosis	INFBASE: 16309234
Tubal factor infertility	INFBASE: 22958786
Male factor infertility	MIK: 17509581
Azoospermia	MIK: 15139971
Non obstructive azoospermia	MIK: 19152933
Oligoasthenozoospermia	MIK: 19152933
Obstructive azoospermia	MIK: 19152933
Spermatogenesis defects	MIK: 15831281
Spermatogenesis defects	MIK: 15896468
Endometriosis	INFBASE: 24661731
Chronic renal failure	GAD: 21085059
Azoopsermia	MIK: 15139971
Oligoasthenozoospermia	MIK: 19152933
Nonobstructive azoospermia	MIK: 19152933
Male infertility	MIK: 16372125
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
19152933	Obstructive azoospermia, oligo-asthenozoospermia, nonobstructive azoospermia			94 (23 healthy fertile volunteers, 22 men with oligo-asthenozoospermia, 37 with nonobstructive azoospermia and 12 with obstructive azoospermia)	Male infertility
15896468	Spermatogenic defects			69 (testicular germ cell tumors (TGCTs, n=28), normal testes (n=19) and testes with defective spermatogenesis (n=22))	Male infertility
15831281	Spermatogenic failure			49 infertile men presenting with azoospermia	Male infertility
15139971	Male infertility, Spermatogenic defects, Azoopsermia			30 (10 normal spermatogenesis, 6 post meiotic spermatogenic arrest, 2 post-meiotic arrest, 2 pre-meiotic maturation arrest, 10 Sertoli-cell-only syndrome)	Male infertility
16372125	Spermatogenetic defects, Male infertility			39 (11 normal testes, 28 testes with defective spermatogenesis)	Male infertility	hTERT survivin
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R