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Gene id 3190
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol HNRNPK   Gene   UCSC   Ensembl
Aliases AUKS, CSBP, HNRPK, TUNP
Gene name heterogeneous nuclear ribonucleoprotein K
Alternate names heterogeneous nuclear ribonucleoprotein K, dC-stretch binding protein, transformation upregulated nuclear protein,
Gene location 9q21.32 (83980781: 83968082)     Exons: 18     NC_000009.12
Gene summary(Entrez) This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in th

Protein Summary
Protein general information P61978  

Name: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up regulated nuclear protein) (TUNP)

Length: 463  Mass: 50976

Sequence METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNAS
VSVPDSSGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLL
IHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPY
DPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRG
GSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAIDTWSPSEWQMAYEPQGGSGYDYSYAG
GRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYL
LQNSVKQYSGKFF
Structural information
Protein Domains
 (42..10-)
(/note="KH-1)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00117-)
(144..20-)
(/note="KH-2)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00117-)
(387..45-)
(/note="KH-3)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00117"-)
Interpro:  IPR033090  IPR004087  IPR004088  IPR036612  IPR012987  
Prosite:   PS50084

PDB:  		 1J5K 1KHM 1ZZI 1ZZJ 1ZZK
PDBsum:   1J5K 1KHM 1ZZI 1ZZJ 1ZZK

DIP:  
31805
MINT:  
STRING:   ENSP00000365439
Other Databases GeneCards:  HNRNPK  Malacards:  HNRNPK

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0010494 cytoplasmic stress granul
e
 ISS cellular component
GO:0003729 mRNA binding
 IBA molecular function
GO:0006357 regulation of transcripti
on by RNA polymerase II
 IBA biological process
GO:0048024 regulation of mRNA splici
ng, via spliceosome
 IBA biological process
GO:0051252 regulation of RNA metabol
ic process
 IBA biological process
GO:0005634 nucleus
 IBA cellular component
GO:0005737 cytoplasm
 IBA cellular component
GO:0010468 regulation of gene expres
sion
 IBA biological process
GO:0071013 catalytic step 2 spliceos
ome
 IDA cellular component
GO:0000398 mRNA splicing, via splice
osome
 IC biological process
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0006357 regulation of transcripti
on by RNA polymerase II
 IEA biological process
GO:0006396 RNA processing
 IEA biological process
GO:0003676 nucleic acid binding
 IEA molecular function
GO:0003677 DNA binding
 IEA molecular function
GO:0003723 RNA binding
 IEA molecular function
GO:0030054 cell junction
 IEA cellular component
GO:0042995 cell projection
 IEA cellular component
GO:0005681 spliceosomal complex
 IEA cellular component
GO:0003723 RNA binding
 IEA molecular function
GO:0003677 DNA binding
 IEA molecular function
GO:0008380 RNA splicing
 IEA biological process
GO:0005737 cytoplasm
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0016032 viral process
 IEA biological process
GO:0006397 mRNA processing
 IEA biological process
GO:0003723 RNA binding
 TAS molecular function
GO:0005737 cytoplasm
 TAS cellular component
GO:0005634 nucleus
 TAS cellular component
GO:0005634 nucleus
 TAS cellular component
GO:0007165 signal transduction
 TAS biological process
GO:0006396 RNA processing
 TAS biological process
GO:0043066 negative regulation of ap
optotic process
 IMP biological process
GO:0005515 protein binding
 IPI molecular function
GO:0000398 mRNA splicing, via splice
osome
 TAS biological process
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0016070 RNA metabolic process
 TAS biological process
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0010494 cytoplasmic stress granul
e
 IEA cellular component
GO:1902165 regulation of intrinsic a
poptotic signaling pathwa
y in response to DNA dama
ge by p53 class mediator
 IEA biological process
GO:0048025 negative regulation of mR
NA splicing, via spliceos
ome
 IEA biological process
GO:0045944 positive regulation of tr
anscription by RNA polyme
rase II
 IEA biological process
GO:0003723 RNA binding
 IEA molecular function
GO:0000978 RNA polymerase II cis-reg
ulatory region sequence-s
pecific DNA binding
 IMP molecular function
GO:0001228 DNA-binding transcription
activator activity, RNA
polymerase II-specific
 IMP molecular function
GO:0045296 cadherin binding
 HDA molecular function
GO:0003697 single-stranded DNA bindi
ng
 TAS molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0048260 positive regulation of re
ceptor-mediated endocytos
is
 IMP biological process
GO:0000790 nuclear chromatin
 IDA cellular component
GO:0010988 regulation of low-density
lipoprotein particle cle
arance
 IMP biological process
GO:0045716 positive regulation of lo
w-density lipoprotein par
ticle receptor biosynthet
ic process
 IMP biological process
GO:0045944 positive regulation of tr
anscription by RNA polyme
rase II
 IMP biological process
GO:0002102 podosome
 IEA cellular component
GO:0005654 nucleoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005654 nucleoplasm
 IDA cellular component
GO:0003723 RNA binding
 HDA molecular function
GO:0003723 RNA binding
 HDA molecular function
GO:0005925 focal adhesion
 HDA cellular component
GO:0070062 extracellular exosome
 HDA cellular component
GO:0070062 extracellular exosome
 HDA cellular component
GO:0016020 membrane
 HDA cellular component
GO:0070062 extracellular exosome
 HDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0019904 protein domain specific b
inding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa05206MicroRNAs in cancer
hsa05203Viral carcinogenesis
hsa03040Spliceosome

Diseases

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Associated diseases References
Au-Kline syndrome KEGG:H01930
Au-Kline syndrome KEGG:H01930
Prostate cancer PMID:19401687
colorectal cancer PMID:21194727
Aberrant CpGs in Low Motility Sperm MIK: 21674046

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract