• Gene id: 3176

Gene Summary

• Gene Symbol: HNMT   Gene   UCSC   Ensembl
• Aliases: HMT, HNMT-S1, HNMT-S2, MRT51
• Gene name: histamine N-methyltransferase
• Alternate names: histamine N-methyltransferase,
• Gene location: 2q22.1 (137964067: 138016363)     Exons: 9     NC_000002.12
• Gene summary(Entrez): In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methioni
• OMIM: 605238

Protein Summary

• Protein general information: P50135  
  • Name: Histamine N methyltransferase (HMT) (EC 2.1.1.8)
  • Length: 292  
  • Mass: 33295
• Sequence:

  MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQ
  AQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKD
  IPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMD
  ISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA

• Structural information:
  • Interpro: IPR016673  IPR029063  
  • Prosite: PS51597
  • PDB: 1ICZ 1JQD 1JQE 2AOT 2AOU 2AOV 2AOW 2AOX
  • PDBsum: 1ICZ 1JQD 1JQE 2AOT 2AOU 2AOV 2AOW 2AOX
  • STRING: ENSP00000280097
• Other Databases: GeneCards:  HNMT  Malacards:  HNMT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005829	cytosol	IDA	is active in
GO:0001692	histamine metabolic process	IMP	biological process
GO:0001695	histamine catabolic process	IDA	biological process
GO:0032259	methylation	IDA	biological process
GO:0046539	histamine N-methyltransferase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0008170	N-methyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0007585	respiratory gaseous exchange by respiratory system	TAS	biological process
GO:0046539	histamine N-methyltransferase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006548	histidine catabolic process	TAS	biological process
GO:0046539	histamine N-methyltransferase activity	TAS	molecular function
GO:0070555	response to interleukin-1	IEA	biological process
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0046539	histamine N-methyltransferase activity	IEA	molecular function
GO:0043005	neuron projection	IEA	cellular component
GO:0006972	hyperosmotic response	IEA	biological process
GO:0002347	response to tumor cell	IEA	biological process
GO:0008170	N-methyltransferase activity	IEA	molecular function
GO:0042220	response to cocaine	IEA	biological process
GO:0035902	response to immobilization stress	IEA	biological process
GO:0014075	response to amine	IEA	biological process
GO:0007420	brain development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00340	Histidine metabolism

Diseases

Associated diseases	References
Autosomal recessive mental retardation	KEGG:H00768
Autosomal recessive mental retardation	KEGG:H00768
Pick's disease	PMID:11880199
Huntington's disease	PMID:21106039
Down syndrome	PMID:11880199
Parkinson's disease	PMID:17985251
Asthma	PMID:21040557
Asthma	PMID:10803682
Atopic dermatitis	PMID:19025430
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)