• Gene id: 3151

Gene Summary

• Gene Symbol: HMGN2   Gene   UCSC   Ensembl
• Aliases: HMG17
• Gene name: high mobility group nucleosomal binding domain 2
• Alternate names: non-histone chromosomal protein HMG-17, high mobility group nucleosome-binding domain-containing protein 2, high mobility group protein N2, high-mobility group (nonhistone chromosomal) protein 17, nonhistone chromosomal protein HMG-17,
• Gene location: 1p36.11 (26472439: 26476641)     Exons: 6     NC_000001.11
• Gene summary(Entrez): The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The pr
• OMIM: 603967

Protein Summary

• Protein general information: P05204  
  • Name: Non histone chromosomal protein HMG 17 (High mobility group nucleosome binding domain containing protein 2)
  • Length: 90  
  • Mass: 9393
• Sequence:

  MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDA
  KTDQAQKAEGAGDAK

• Structural information:
  • Interpro: IPR000079  
  • Prosite: PS00355
  • STRING: ENSP00000355228
• Other Databases: GeneCards:  HMGN2  Malacards:  HMGN2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031492	nucleosomal DNA binding	IEA	molecular function
GO:0000785	chromatin	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0031640	killing of cells of other organism	IMP	biological process
GO:0031640	killing of cells of other organism	IMP	biological process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881