Male Infertility Database

Search Result

Gene id

3123

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed

Gene Summary

Gene Symbol

HLA-DRB1 Gene UCSC Ensembl

Aliases

DRB1, HLA-DR1B, HLA-DRB, SS1

Gene name

major histocompatibility complex, class II, DR beta 1

Alternate names

major histocompatibility complex, class II, DR beta 1, HLA class II histocompatibility antigen, DR-1 beta chain, MHC class II HLA-DR beta 1 chain, human leucocyte antigen DRB1, lymphocyte antigen DRB1,

Gene location

6p21.32 (32589835: 32578768) Exons: 6 NC_000006.12

Gene summary(Entrez)

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derive

OMIM

142857

Protein Summary

Protein general information

P01911

Name: HLA class II histocompatibility antigen, DRB1 15 beta chain (DW2.2/DR2.2) (MHC class II antigen DRB1*15)

Length: 266 Mass: 29,966

Tissue specificity: Specifically expressed in adult testis.

Sequence

MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGE
FRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSG
FYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Structural information

Protein Domains	Ig-like (126-214)
Interpro:	IPR007110 IPR036179 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290
PDB:	1BX2 1YMM 2WBJ
PDBsum:	1BX2 1YMM 2WBJ
STRING:	ENSP00000353099

Other Databases

GeneCards: HLA-DRB1 Malacards: HLA-DRB1

Protein general information

P01912

Name: HLA class II histocompatibility antigen, DRB1 3 chain (Clone P2 beta 3) (MHC class II antigen DRB1*3)

Length: 266 Mass: 30,120

Tissue specificity: Specifically expressed in adult testis.

Sequence

MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTSECHFFNGTERVRYLDRYFHNQEENVRFDSDVGE
FRAVTELGRPDAEYWNSQKDLLEQKRGRVDNYCRHNYGVVESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSG
FYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPRGFLS

Structural information

Protein Domains	Ig-like (126-214)
Interpro:	IPR007110 IPR036179 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290
PDB:	1A6A
PDBsum:	1A6A
DIP:	6064
MINT:

Other Databases

GeneCards: HLA-DRB1 Malacards: HLA-DRB1

Protein general information

P13761

Name: HLA class II histocompatibility antigen, DRB1 7 beta chain (MHC class II antigen DRB1*7) (DR 7) (DR7)

Length: 266 Mass: 29,822

Tissue specificity: Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Un

Sequence

MVCLKLPGGSCMAALTVTLMVLSSPLALAGDTQPRFLWQGKYKCHFFNGTERVQFLERLFYNQEEFVRFDSDVGE
YRAVTELGRPVAESWNSQKDILEDRRGQVDTVCRHNYGVGESFTVQRRVHPEVTVYPAKTQPLQHHNLLVCSVSG
FYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVMSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Structural information

Protein Domains	Ig-like (126-216)
Interpro:	IPR007110 IPR036179 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290

Other Databases

GeneCards: HLA-DRB1 Malacards: HLA-DRB1

Protein general information

Q29974

Name: HLA class II histocompatibility antigen, DRB1 16 beta chain (MHC class II antigen DRB1*16) (DR 16) (DR16)

Length: 266 Mass: 30,030

Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers. {ECO

Sequence

MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGE
YRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSG
FYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Structural information

Protein Domains	Ig-like (126-214)
Interpro:	IPR007110 IPR036179 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290

Other Databases

GeneCards: HLA-DRB1 Malacards: HLA-DRB1

Gene ontology

Expand All | Collapse All

GO accession	Term name	Evidence code	Go category
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002506	polysaccharide assembly w ith MHC class II protein complex	IDA	biological process
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0023026	MHC class II protein comp lex binding	IDA	molecular function
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002376	immune system process	IEA	biological process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological process
GO:0002506	polysaccharide assembly w ith MHC class II protein complex	IDA	biological process
GO:0005764	lysosome	IEA	cellular component
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	IEA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0010008	endosome membrane	IEA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0019882	antigen processing and pr esentation	IEA	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0023026	MHC class II protein comp lex binding	IDA	molecular function
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IEA	cellular component
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002506	polysaccharide assembly w ith MHC class II protein complex	IDA	biological process
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0023026	MHC class II protein comp lex binding	IDA	molecular function
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological process
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002376	immune system process	IEA	biological process
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological process
GO:0005764	lysosome	IEA	cellular component
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	IEA	biological process
GO:0010008	endosome membrane	IEA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0019882	antigen processing and pr esentation	IEA	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IEA	cellular component
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological process
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0042613	MHC class II protein comp lex	IDA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological process
GO:0002437	inflammatory response to antigenic stimulus	IDA	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	TAS	biological process
GO:0006955	immune response	IDA	biological process
GO:0006955	immune response	IDA	biological process
GO:0006955	immune response	IMP	biological process
GO:0009897	external side of plasma m embrane	IDA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	TAS	cellular component
GO:0016045	detection of bacterium	IMP	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032395	MHC class II receptor act ivity	TAS	molecular function
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032673	regulation of interleukin -4 production	IDA	biological process
GO:0032689	negative regulation of in terferon-gamma production	IMP	biological process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	IMP	biological process
GO:0042088	T-helper 1 type immune re sponse	IMP	biological process
GO:0042130	negative regulation of T cell proliferation	IMP	biological process
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0051262	protein tetramerization	IDA	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:2001179	regulation of interleukin -10 secretion	IDA	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002376	immune system process	IEA	biological process
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological process
GO:0002437	inflammatory response to antigenic stimulus	IDA	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005764	lysosome	IEA	cellular component
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	IEA	biological process
GO:0006955	immune response	TAS	biological process
GO:0006955	immune response	IDA	biological process
GO:0006955	immune response	IDA	biological process
GO:0006955	immune response	IMP	biological process
GO:0009897	external side of plasma m embrane	IDA	cellular component
GO:0010008	endosome membrane	IEA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	TAS	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0016045	detection of bacterium	IMP	biological process
GO:0019882	antigen processing and pr esentation	IEA	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IEA	cellular component
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032395	MHC class II receptor act ivity	TAS	molecular function
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032673	regulation of interleukin -4 production	IDA	biological process
GO:0032689	negative regulation of in terferon-gamma production	IMP	biological process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	IMP	biological process
GO:0042088	T-helper 1 type immune re sponse	IMP	biological process
GO:0042130	negative regulation of T cell proliferation	IMP	biological process
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0051262	protein tetramerization	IDA	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:2001179	regulation of interleukin -10 secretion	IDA	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological process
GO:0002437	inflammatory response to antigenic stimulus	IDA	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	TAS	biological process
GO:0006955	immune response	IDA	biological process
GO:0006955	immune response	IDA	biological process
GO:0006955	immune response	IMP	biological process
GO:0009897	external side of plasma m embrane	IDA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	TAS	cellular component
GO:0016045	detection of bacterium	IMP	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032395	MHC class II receptor act ivity	TAS	molecular function
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032673	regulation of interleukin -4 production	IDA	biological process
GO:0032689	negative regulation of in terferon-gamma production	IMP	biological process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	IMP	biological process
GO:0042088	T-helper 1 type immune re sponse	IMP	biological process
GO:0042130	negative regulation of T cell proliferation	IMP	biological process
GO:0042605	peptide antigen binding	IDA	molecular function
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0051262	protein tetramerization	IDA	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:2001179	regulation of interleukin -10 secretion	IDA	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	ISS	biological process
GO:0002437	inflammatory response to antigenic stimulus	ISS	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	ISS	biological process
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	ISS	biological process
GO:0006955	immune response	NAS	biological process
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	NAS	cellular component
GO:0016045	detection of bacterium	ISS	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032395	MHC class II receptor act ivity	NAS	molecular function
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032673	regulation of interleukin -4 production	ISS	biological process
GO:0032689	negative regulation of in terferon-gamma production	ISS	biological process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	ISS	biological process
GO:0042088	T-helper 1 type immune re sponse	ISS	biological process
GO:0042130	negative regulation of T cell proliferation	ISS	biological process
GO:0042605	peptide antigen binding	ISS	molecular function
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0051262	protein tetramerization	ISS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:2001179	regulation of interleukin -10 secretion	ISS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002376	immune system process	IEA	biological process
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	ISS	biological process
GO:0002437	inflammatory response to antigenic stimulus	ISS	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	ISS	biological process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological process
GO:0005764	lysosome	IEA	cellular component
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	IEA	biological process
GO:0006955	immune response	ISS	biological process
GO:0006955	immune response	NAS	biological process
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0010008	endosome membrane	IEA	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	NAS	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0016045	detection of bacterium	ISS	biological process
GO:0019882	antigen processing and pr esentation	IEA	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IEA	cellular component
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032395	MHC class II receptor act ivity	NAS	molecular function
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032673	regulation of interleukin -4 production	ISS	biological process
GO:0032689	negative regulation of in terferon-gamma production	ISS	biological process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	ISS	biological process
GO:0042088	T-helper 1 type immune re sponse	ISS	biological process
GO:0042130	negative regulation of T cell proliferation	ISS	biological process
GO:0042605	peptide antigen binding	ISS	molecular function
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0042613	MHC class II protein comp lex	IEA	cellular component
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0051262	protein tetramerization	ISS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:2001179	regulation of interleukin -10 secretion	ISS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	ISS	biological process
GO:0002437	inflammatory response to antigenic stimulus	ISS	biological process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	ISS	biological process
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005765	lysosomal membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006955	immune response	ISS	biological process
GO:0006955	immune response	NAS	biological process
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular component
GO:0016020	membrane	NAS	cellular component
GO:0016045	detection of bacterium	ISS	biological process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological process
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030658	transport vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030666	endocytic vesicle membran e	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular component
GO:0031295	T cell costimulation	TAS	biological process
GO:0031902	late endosome membrane	IDA	cellular component
GO:0032395	MHC class II receptor act ivity	NAS	molecular function
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032588	trans-Golgi network membr ane	TAS	cellular component
GO:0032673	regulation of interleukin -4 production	ISS	biological process
GO:0032689	negative regulation of in terferon-gamma production	ISS	biological process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	ISS	biological process
GO:0042088	T-helper 1 type immune re sponse	ISS	biological process
GO:0042130	negative regulation of T cell proliferation	ISS	biological process
GO:0042605	peptide antigen binding	ISS	molecular function
GO:0050852	T cell receptor signaling pathway	TAS	biological process
GO:0051262	protein tetramerization	ISS	biological process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular component
GO:2001179	regulation of interleukin -10 secretion	ISS	biological process

KEGG pathways

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Pathway id	Pathway name
hsa00600	Sphingolipid metabolism
hsa00591	Linoleic acid metabolism
hsa00380	Tryptophan metabolism
hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series
hsa00750	Vitamin B6 metabolism
hsa00670	One carbon pool by folate
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa04015	Rap1 signaling pathway
hsa04015	Rap1 signaling pathway
hsa04015	Rap1 signaling pathway
hsa04015	Rap1 signaling pathway
hsa04015	Rap1 signaling pathway
hsa04010	MAPK signaling pathway
hsa04010	MAPK signaling pathway
hsa04010	MAPK signaling pathway
hsa04010	MAPK signaling pathway
hsa04310	Wnt signaling pathway
hsa04310	Wnt signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04390	Hippo signaling pathway
hsa04370	VEGF signaling pathway
hsa04371	Apelin signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04630	JAK-STAT signaling pathway
hsa04514	Cell adhesion molecules
hsa04145	Phagosome
hsa04640	Hematopoietic cell lineage
hsa04612	Antigen processing and presentation
hsa04658	Th1 and Th2 cell differentiation
hsa04659	Th17 cell differentiation
hsa04672	Intestinal immune network for IgA production
hsa05310	Asthma
hsa05322	Systemic lupus erythematosus
hsa05323	Rheumatoid arthritis
hsa05320	Autoimmune thyroid disease
hsa05321	Inflammatory bowel disease
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05416	Viral myocarditis
hsa04940	Type I diabetes mellitus
hsa05150	Staphylococcus aureus infection
hsa05152	Tuberculosis
hsa05166	Human T-cell leukemia virus 1 infection
hsa05164	Influenza A
hsa05168	Herpes simplex virus 1 infection
hsa05169	Epstein-Barr virus infection
hsa05145	Toxoplasmosis
hsa05140	Leishmaniasis

Diseases

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Associated diseases	References
Cancer	GAD: 11027344
Cancer (Adenocarcinoma)	GAD: 11289148
Cancer (B-Cell lymphomas)	GAD: 17311253
Cancer (brain)	GAD: 19487887
Cancer (breast)	GAD: 11027344
Cancer (cervical)	GAD: 12648582
Cancer (chronic B-cell leukemias)	GAD: 17488703
Cancer (colorectal)	GAD: 19251712
Cancer (esophageal)	GAD: 11860824
Cancer (gastric)	GAD: 12870731
Cancer (glaucoma)	GAD: 21031025
Cancer (glioblastoma)	GAD: 16103458
Cancer (granuloma)	GAD: 18196245
Cancer (head and neck)	GAD: 16573562
Cancer (Hematologic)	GAD: 19589487
Cancer (Hepatocellular)	GAD: 11318984
Cancer (Kaposi's sarcoma)	GAD: 15075536
Cancer (kidney)	GAD: 12771724
Cancer (laryngeal)	GAD: 12525627
Cancer (leukemia)	GAD: 16215957
Cancer (liver)	GAD: 15556690
Cancer (lung)	GAD: 19246116
Cancer (lymphoma)	GAD: 15120192
Cancer (melanoma)	GAD: 15191529
Cancer (meningioma)	GAD: 14693734
Cancer (myeloma)	GAD: 18397187
Cancer (nasopharyngeal)	GAD: 19714482
Cancer (ovarian)	GAD: 15935893
Cancer (Papilary)	GAD: 20164547
Cancer (Squamous cell)	GAD: 18535809
Cancer (stomach)	GAD: 11985790
Cancer (testicular)	GAD: 16720210
Cancer (thyroid)	GAD: 16430717
Colorectal cancer	GAD: 19251712
Paraneoplastic syndromes	GAD: 20547426
Aneurysm	GAD: 11436079
Aortic aneurysm	GAD: 17182961
Aortoarteritis	GAD: 12358152
Apoplexy	GAD: 15849775
Atherosclerosis	GAD: 15825968
Brugada syndrome	GAD: 17124999
Cardiovascular disease	GAD: 12820921
Hypertension	GAD: 15192840
Thrombosis	GAD: 19922436
Dilated cardiomyopathy	KEGG: H00294
Brain infarction	GAD: 16700999
Hemochromatosis	GAD: 3569756
Neuropathy	GAD: 16053028
Primary biliary cirrhosis	GAD: 15975271
Liver disease	GAD: 19811438
Hashimoto disease	GAD: 18599937
Polyendocrinopathies	GAD: 18390988
Hashimoto disease	KEGG: H00081
Graves disease	GAD: 15993720
Ophthalmia	GAD: 11222331
Macular degeneration	GAD: 15851575
Eye diseases	GAD: 18385790
Retinopathy	GAD: 12694588
Trachoma	GAD: 18824733
Uveitis	GAD: 16019679
Ocular cicatricial pemphigoid	GAD: 2653736
Agranulocytosis	GAD: 11266078
AHG deficiency disease	GAD: 20536993
Anemia	GAD: 18571007
Aplastic anemia	GAD: 19860590
Hemophilia	GAD: 15357778
Hemorrhagic Fever with Renal Syndrome	GAD: 19473214
Sickle cell anemia	GAD: 11872237
Myelodysplastic syndrome	GAD: 19593744
Sarcoidosis	GAD: 14508706
Neutropenia	GAD: 19210322
Mucocutaneous lymph node syndrome	GAD: 18064508
Hodgkin disease	GAD: 12351419
Eosinophilic granulomatosis with polyangiitis	KEGG: H01468
Idiopathic thrombocytopenic purpura	GAD: 20141578
Pulmonary sarcoidosis	GAD: 12600814
Addison's disease	GAD: 16849401
Allergy	GAD: 15853900
Alopecia areata	GAD: 11978563
Alveolitis	GAD: 16362107
Ankylosing spondylitis	GAD: 12118167
Antiphospholipid syndrome	GAD: 11157139
Arthritis	GAD: 12124858
Carpal tunnel syndrome	GAD: 18854880
Atopy	GAD: 10452762
Autoimmune diseases	GAD: 12734793
Autoimmune diseases	GAD: 12734793
Autoimmune diseases	GAD: 11678832
Behcet's disease	GAD: 19038507
Behcet's disease	GAD: 19038507
Celiac disease	GAD: 11045836
Chronic ulcerative colitis	GAD: 12507822
Churg-Strauss Syndrome	GAD: 17763415
Celiac disease	GAD: 19474744
Ulcerative colitis	GAD: 18416774
Crohn's disease	GAD: 11423176
Cryoglobulinemia	GAD: 11592376
Cutaneous neonatal lupus	GAD: 15334474
Inflammatory bowel disease	GAD: 12656131
Bullous pemphigoid	GAD: 12139680
Juvenile arthritis	GAD: 15641099
Sjogren's syndrome	GAD: 11093441
Rheumatoid arthritis	GAD: 18838388
Ulcerative colitis	GAD: 11113070
Multiple sclerosis	GAD: 15856071
Rheumatoid arthritis	GAD: 14730600
Ankylosing spondylitis	GAD: 19565552
Psoriasis	GAD: 11872240
Inflammatory myopathies	GAD: 11972875
Psoriatic arthritis	GAD: 12022360
Psoriatic arthritis	GAD: 15554365
Systemic lupus erythematosus (SLE)	GAD: 18569076
Systemic lupus erythematosus (SLE)	GAD: 11607787
Asthma	KEGG: H00079
Sjogren's syndrome	KEGG: H01502
Juvenile rheumatoid arthritis	GAD: 19210888
Hypersensitivity	GAD: 19860744
Amyloidosis	GAD: 15175852
Biliary atresia	GAD: 12100571
Cholangitis	GAD: 12235090
Cholelithiasis	GAD: 18554163
Cholestasis	GAD: 18554163
Diabetes	GAD: 7914753
Diabetes	GAD: 2075785
Biliary cirrhosis	GAD: 19003916
Diabetes	KEGG: H00408
Degenerative arthropathy	GAD: 16855521
Osteoarthritis	GAD: 12594107
Osteoporosis	GAD: 17498269
Myopathy	GAD: 12124873
Myositis	GAD: 19690132
Polymyositis	GAD: 15022353
Eosinophilia-Myalgia Syndrome	GAD: 19790128
Dermatomyositis	GAD: 19035492
Rheumatic diseases	GAD: 15124939
Rheumatic diseases	GAD: 14602216
Dystonia	GAD: 14581671
Encephalomyelitis	GAD: 19722042
Paraparesis	GAD: 20851016
Polyneuropathies	GAD: 18789688
Stroke	GAD: 12373032
Giant cell arteritis	KEGG: H01698
Polyangiitis	GAD: 16208405
Microscopic polyangiitis	GAD: 12858454
Vogt-Koyanagi-Harada syndrome	GAD: 12903490
Uveomeningoencephalitic syndrome	GAD: 19452015
Myasthenia gravis	GAD: 12770797
Guillain-Barre syndrome	GAD: 11776098
Fatigue Syndrome	GAD: 19822091
Sporadic inclusion body myositis	GAD: 15496200
Alzheimer's disease	GAD: 10568518
Epilepsy	GAD: 1396421
Arthrofibrosis	GAD: 15122136
Beryllium disease	GAD: 14662898
Chronic fatigue syndrome	GAD: 16049290
Delayed sleep phase syndrome.	GAD: 10498237
Meniere disease	GAD: 17592398
Sensorineural hearing loss	GAD: 16303674
Attention deficit hyperactivity disorder (ADHD)	GAD: 19144284
Autism	GAD: 8765331
Bipolar disorder	GAD: 12109964
Schizophrenia	GAD: 8942447
Psychological disorders	GAD: 20606439
Chronic renal failure	GAD: 14700599
Kidney diseases	GAD: 17401504
Abortion	GAD: 20307907
Congenital adrenal hyperplasia	GAD: 19201236
Azoospermia	GAD: 14718045
Congenital adrenal hyperplasia	GAD: 19201236
Adenomyosis	GAD: 11836687
Hypothyroidism	GAD: 17588142
Preeclampsia	GAD: 12443029
Recurrent pregnancy loss (RPL)	GAD: 16122986
Recurrent pregnancy loss (RPL)	GAD: 16122986
Recurrent pregnancy loss (RPL)	GAD: 14976605
X-linked adrenoleukodystrophy	GAD: 7488132
Endometriosis	INFBASE: 6594014
Female infertility	INFBASE: 20797713
Female infertility	INFBASE: 10708242
Premature ovarian insufficiency (POI)	INFBASE: 21811055
Polycystic ovary syndrome (PCOS)	INFBASE: 21851420
Miscarriage	INFBASE: 9806576
Ovarian endometriosis	INFBASE: 15665016
Premature ovarian failure (POF)	INFBASE: 10084595
Recurrent pregnancy loss (RPL)	INFBASE: 7762569
Turners syndrome	INFBASE: 8082315
Cryptorchidism	MIK: 21955839
Gonadal dysgenesis	MIK: 7834897
Immunoinfertility	MIK: 10708242
Male factor infertility	MIK: 10611211
Male factor infertility	MIK: 11168645
Sperm autoantibodies	MIK: 2609327
Non obstructive azoospermia	MIK: 10452599
Spermatogenesis defects	MIK: 10611211
Unexplained azoospermia	MIK: 26662397
Spermatogenesis defects	MIK: 14718045
Unexplained infertility	MIK: 10668156
Spermatogenesis defects	MIK: 14718045
Spermatogenesis defects	MIK: 26662397
Silicosis	GAD: 14694619
Pulmonary fibrosis	GAD: 16133177
Pulmonary hypertension	GAD: 15640334
Nasal polyposis	GAD: 17305280
Rhinitis	GAD: 12541760
Goodpasture's disease	GAD: 15199166
Dermatitis	GAD: 18007983
Erythema	GAD: 17116345
Warts	GAD: 15257408
Pityriasis rosea	GAD: 16405603
Systemic scleroderma	GAD: 18799094
Systemic Scleroderma	GAD: 19884273
Vitiligo	GAD: 15140072
Systemic sclerosis	KEGG: H01492
Varicose ulcer	GAD: 20854863
Epidermal Necrolysis	GAD: 19668019
Urticaria	GAD: 16201295
Alpha 1-antitrypsin deficiency	GAD: 1975247
Bronchiectasis	GAD: 18241227
Calcinosis	GAD: 19479859
Complex Regional Pain Syndromes	GAD: 19523767
Diffuse panbonchiolitis	GAD: 18846964
Myelopathy	GAD: 11163081
Vulval lichen sclerosus	GAD: 16297186
Adult onset still's disease	KEGG: H01516
Juvenile multiple sclerosis	GAD: 11865153
Renal disease	GAD: 11082516
Nephropathy	GAD: 12651073
Hemoglobinuria	GAD: 18396213
Nephrotic syndrome	GAD: 17180363
Proteinuria	GAD: 18449568
Cryptorchidism	MIK: 21955839
Gonadal dysgenesis	MIK: 7834897
Male infertility	MIK: 11168645
Nonobstructive�azoospermia	MIK: 10452599
Spermatogenic defects	MIK: 31037746
Unexplained azoospermia	MIK: 26662397

PubMed references

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PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
14718045	Spermatoge nic defect s	DRB11302-DQB10604 haplotype	Japanes e	60 infertile pa tients	Male infertility		Show abstract
12366783	Non-obstru ctive�azoo spermia	DRB11302 and DQB10604			Male infertility		Show abstract
10611211	Infertilit y	DRB11501-DQA10102-DQB1*0602		188 (84 tubal i nfertility, 104 male factor in fertility)	Male infertility		Show abstract
10452599	Nonobstruc tive�azoos permia	DRB1*1302	Japanes e	76 infertile me n	Male infertility		Show abstract
21955839	Cryptorchi dism/infer tility	DRB104, DQB106, HLA-DRB*11	Ukraini an	120 ( 60 prepub ertal boys with cryptorchidism , 60 healthy co ntrols )	Male infertility		Show abstract
7834897	Gonadal dy sgenesis			50 patients wit h gonadal dysge nesis (GD), 50 patients thyrog lobulin and/or microsomal anti bodies	Male infertility	HLA-A B and DR	Show abstract
2609327	Male infer tility		Caucasi an	80 ( 22 inferti le with sperm a utoantibodies, 58 infertile wi th sperm autoan tibodies)	Male infertility	HLA-A B and DR	Show abstract
12366783	Non-obstru ctive azoo permia	DRB11302, DQB10604			Male infertility	HLA-DR/DQ	Show abstract
21955839	Cryptorchi dism/infer tility	DRB104, DQB106		120 (60 prepube rtal boys with cryptorchidism, 60 healthy boy s)	Male infertility	HLA-DRB1 HLA-DQB1	Show abstract
10668156	Unexplaine d infertil ity			76 couples (52 couples with un explained infer tility, 15 infe rtile and 9 fer tile couples)	Male infertility, Female infertility		Show abstract
10611211	Spermatoge nesis and male gamet e function				Male infertility		Show abstract
14718045	Severe spe rmatogenic impairmen t	HLA-DRB11302-DQB10604 allele�			Male infertility	HLA-DRB1 HLA- DQB1	Show abstract
11935327	Non-obstru ctive azoo spermia	HLA-DRB1*1302	Japanes e		Male infertility	HLA-DRB1*1302 HLA-A33 -B44	Show abstract
6222922	Unexplaine d infertil ity			14 couples with unexplained in fertility	Male infertility, Female infertility	HLA-DR	Show abstract
2609327	Sperm auto -antibodie s (S.A.A.)		Caucasi an	80 (22 infertil e men with cyto toxic S.A.A. in serum (S) and/ or seminal plas ma (SP), 58 inf ertile men with out cytotoxic S .A.A. in serum (S) and/or semi nal plasma (SP) )	Male infertility	HLA-A HLA-B HLA-DR	Show abstract
11168645	Male infer tility			42 (22 fertile, 20 infertile m en)	Male infertility	HLA I	Show abstract
10452599	Nonobstruc tive azoos permia	�HLA-DRB1*1302 allele			Male infertility	HLA-DR13 HLA-DRB1	Show abstract
10452599	Nonobstruc tive azoos permia	�HLA-DRB1*1302 allele			Male infertility	HLA-DR13 HLA-DRB1	Show abstract
26662397	Unexplaine d azoosper mia	Copy number variations		33 (11 patients with chromosom e abnormalities , 16 males with azoospermia)	Male infertility		Show abstract
31037746	Spermatoge nic defect s			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

Gene ontology

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KEGG pathways

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Diseases

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PubMed references

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

Gene ontology

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KEGG pathways Expand All | Collapse All

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Diseases Expand All | Collapse All

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PubMed references

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KEGG pathways

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Diseases

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