• Gene id: 3101

Gene Summary

• Gene Symbol: HK3   Gene   UCSC   Ensembl
• Aliases: HKIII, HXK3
• Gene name: hexokinase 3
• Alternate names: hexokinase-3, ATP:D-hexose 6-phosphotransferase, HK III, hexokinase 3 (white cell), hexokinase type III, hexokinase-C,
• Gene location: 5q35.2 (176899372: 176880868)     Exons: 22     NC_000005.10
• Gene summary(Entrez): Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [
• OMIM: 139139

Protein Summary

• Protein general information: P52790  
  • Name: Hexokinase 3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase C)
  • Length: 923  
  • Mass: 99025
• Sequence:

  MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRML
  PTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEF
  LDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVG
  TMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLN
  PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLS
  PGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPE
  CDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTF
  VRATPDGSERGDFLALDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
  SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYED
  PRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKM
  ISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMV
  LEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
  DGSGKGAALVTAVACRLAQLTRV

• Structural information:
  • Protein Domains: (27..47-)
    (/note="Hexokinase-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01084-)
    (477..91-)
    (/note="Hexokinase-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01084"-)
  • Interpro: IPR001312  IPR019807  IPR022673  IPR022672  
  • Prosite: PS00378 PS51748
  • PDB: 3HM8
  • PDBsum: 3HM8
  • STRING: ENSP00000292432
• Other Databases: GeneCards:  HK3  Malacards:  HK3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051156	glucose 6-phosphate metabolic process	IBA	biological process
GO:0006096	glycolytic process	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0001678	cellular glucose homeostasis	IBA	biological process
GO:0019158	mannokinase activity	IBA	molecular function
GO:0008865	fructokinase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0004340	glucokinase activity	IBA	molecular function
GO:0008865	fructokinase activity	ISS	molecular function
GO:0004340	glucokinase activity	ISS	molecular function
GO:0051156	glucose 6-phosphate metabolic process	ISS	biological process
GO:0006002	fructose 6-phosphate metabolic process	ISS	biological process
GO:0004396	hexokinase activity	IEA	molecular function
GO:0005536	glucose binding	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0001678	cellular glucose homeostasis	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0006096	glycolytic process	IEA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0006096	glycolytic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0004396	hexokinase activity	IEA	molecular function
GO:0004396	hexokinase activity	IDA	molecular function
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0061621	canonical glycolysis	TAS	biological process
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0019318	hexose metabolic process	IEA	biological process
GO:0006096	glycolytic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05131	Shigellosis
hsa04910	Insulin signaling pathway
hsa01200	Carbon metabolism
hsa04066	HIF-1 signaling pathway
hsa00010	Glycolysis / Gluconeogenesis
hsa00520	Amino sugar and nucleotide sugar metabolism
hsa04930	Type II diabetes mellitus
hsa05230	Central carbon metabolism in cancer
hsa04973	Carbohydrate digestion and absorption
hsa00051	Fructose and mannose metabolism
hsa00500	Starch and sucrose metabolism
hsa00052	Galactose metabolism
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq