• Gene id: 30836

Gene Summary

• Gene Symbol: DNTTIP2   Gene   UCSC   Ensembl
• Aliases: ERBP, FCF2, HSU15552, LPTS-RP2, TdIF2
• Gene name: deoxynucleotidyltransferase terminal interacting protein 2
• Alternate names: deoxynucleotidyltransferase terminal-interacting protein 2, LPTS-interacting protein 2, acidic 82 kDa protein mRNA, estrogen receptor binding protein, tdT-interacting factor 2,
• Gene location: 1p22.1 (93879205: 93866283)     Exons: 7     NC_000001.11
• Gene summary(Entrez): This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase
• OMIM: 611199

Protein Summary

• Protein general information: Q5QJE6  
  • Name: Deoxynucleotidyltransferase terminal interacting protein 2 (Estrogen receptor binding protein) (LPTS interacting protein 2) (LPTS RP2) (Terminal deoxynucleotidyltransferase interacting factor 2) (TdIF2) (TdT interacting factor 2)
  • Length: 756  
  • Mass: 84469
  • Tissue specificity: Widely expressed with higher levels in testis. {ECO
• Sequence:

  MVVTRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDARTTAESQTTGKQSLIPRTPKARKRKSRTTGSL
  PKGTEPSTDGETSEAESNYSVSEHHDTILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGI
  SRIVLPTEKTTGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKDSKIVPGN
  EKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSENILTVHEQANVESLKETKQNCKDLD
  EDANGITDEGKEINEKSSQLKNLSELQDTSLQQLVSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRW
  NNNKKSPIKASDLTKFGDCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDES
  QQSENSENEEDTLCFVENSGQRESLSGDTGSLSCDNALFVIDTTPGMSADKNFYLEEEDKASEVAIEEEKEEEED
  EKSEEDSSDHDENEDEFSDEEDFLNSTKAKLLKLTSSSIDPGLSIKQLGGLYINFNADKLQSNKRTLTQIKEKKK
  NELLQKAVITPDFEKNHCVPPYSESKYQLQKKRRKERQKTAGDGWFGMKAPEMTNELKNDLKALKMRASMDPKRF
  YKKNDRDGFPKYFQIGTIVDNPADFYHSRIPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRK
  KKKFRN

• Structural information:
  • Interpro: IPR039883  IPR014810  
  • STRING: ENSP00000411010
• Other Databases: GeneCards:  DNTTIP2  Malacards:  DNTTIP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)