• Gene id: 30816

Gene Summary

• Gene Symbol: ERVW-1   Gene   UCSC   Ensembl
• Aliases: ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV
• Gene name: endogenous retrovirus group W member 1, envelope
• Alternate names: syncytin-1, HERV-7q envelope protein, HERV-W Env glycoprotein, HERV-W envelope protein, HERV-W_7q21.2 provirus ancestral Env polyprotein, HERV-tryptophan envelope protein, endogenous retroviral family W, env(C7), member 1, endogenous retrovirus group W member 1, ,
• Gene location: 7q21.2 (92477945: 92468379)     Exons: 2     NC_000007.14
• Gene summary(Entrez): Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivati
• OMIM: 604659

Protein Summary

• Protein general information: Q9UQF0  
  • Name: Syncytin 1 (Endogenous retrovirus group W member 1) (Env W) (Envelope polyprotein gPr73) (Enverin) (HERV 7q Envelope protein) (HERV W envelope protein) (HERV W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50
  • Length: 538  
  • Mass: 59866
  • Tissue specificity: Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, th
• Sequence:

  MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHMPRNCYHS
  ATLCMHANTHYWTGKMINPSCPGGLGVTVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLD
  LSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVS
  NLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIY
  TEQDLYSYVISKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSL
  AAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILP
  FLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASPRSDVNDIKGTPPEEISA
  AQPLLRPNSAGSS

• Structural information:
  • Interpro: IPR018154  
  • PDB: 5HA6 6RX1
  • PDBsum: 5HA6 6RX1
  • STRING: ENSP00000419945
• Other Databases: GeneCards:  ERVW-1  Malacards:  ERVW-1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000768	syncytium formation by plasma membrane fusion	IBA	biological process
GO:0006949	syncytium formation	IDA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0019031	viral envelope	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0019012	virion	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0009653	anatomical structure morphogenesis	TAS	biological process
GO:0007520	myoblast fusion	IMP	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0000768	syncytium formation by plasma membrane fusion	IDA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)