• Gene id: 308

Gene Summary

• Gene Symbol: ANXA5   Gene   UCSC   Ensembl
• Aliases: ANX5, ENX2, HEL-S-7, PP4, RPRGL3
• Gene name: annexin A5
• Alternate names: annexin A5, CBP-I, PAP-I, VAC-alpha, anchorin CII, annexin V, annexin-5, calphobindin I, endonexin II, epididymis secretory protein Li 7, lipocortin V, placental anticoagulant protein 4, placental anticoagulant protein I, thromboplastin inhibitor, vascula,
• Gene location: 4q27 (121696993: 121667996)     Exons: 14     NC_000004.12
• Gene summary(Entrez): The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and
• OMIM: 131230

Protein Summary

• Protein general information: P08758  
  • Name: Annexin A5 (Anchorin CII) (Annexin V) (Annexin 5) (Calphobindin I) (CBP I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP I) (Thromboplastin inhibitor) (Vascular anticoagulant alpha) (VAC a
  • Length: 320  
  • Mass: 35,937
• Sequence:

  MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTG
  KFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQ
  RMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETI
  DRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMI
  KGDTSGDYKKALLLLCGEDD

• Structural information:
  • Interpro: IPR001464  IPR018502  IPR018252  IPR037104  IPR002392  
  • Prosite: PS00223
  • PDB: 1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3
  • PDBsum: 1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3
  • STRING: ENSP00000296511
• Other Databases: GeneCards:  ANXA5  Malacards:  ANXA5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002230	positive regulation of defense response to virus by host	IMP	biological process
GO:0004859	phospholipase inhibitor activity	TAS	molecular function
GO:0005388	calcium-transporting ATPase activity	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005543	phospholipid binding	TAS	molecular function
GO:0005544	calcium-dependent phospholipid binding	IDA	molecular function
GO:0005622	intracellular	IDA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0008021	synaptic vesicle	IEA	cellular component
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0014704	intercalated disc	IEA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0017046	peptide hormone binding	IEA	molecular function
GO:0030018	Z disc	IEA	cellular component
GO:0030195	negative regulation of blood coagulation	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0030971	receptor tyrosine kinase binding	IEA	molecular function
GO:0042383	sarcolemma	IEA	cellular component
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043066	negative regulation of apoptotic process	TAS	biological process
GO:0043086	negative regulation of catalytic activity	IEA	biological process
GO:0043204	perikaryon	IEA	cellular component
GO:0043679	axon terminus	IEA	cellular component
GO:0051260	protein homooligomerization	IEA	biological process
GO:0051592	response to calcium ion	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070588	calcium ion transmembrane transport	IEA	biological process
GO:0071284	cellular response to lead ion	IEA	biological process
GO:0072563	endothelial microparticle	IEA	cellular component
GO:0097066	response to thyroid hormone	IEA	biological process
GO:0097211	cellular response to gonadotropin-releasing hormone	IEA	biological process
GO:0098779	mitophagy in response to mitochondrial depolarization	IGI	biological process
GO:0098792	xenophagy	IMP	biological process
GO:1901317	regulation of flagellated sperm motility	IEA	biological process
GO:1902721	negative regulation of prolactin secretion	IEA	biological process
GO:0002230	positive regulation of defense response to virus by host	IMP	biological process
GO:0004859	phospholipase inhibitor activity	TAS	molecular function
GO:0005388	calcium-transporting ATPase activity	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005543	phospholipid binding	TAS	molecular function
GO:0005544	calcium-dependent phospholipid binding	IEA	molecular function
GO:0005544	calcium-dependent phospholipid binding	IEA	molecular function
GO:0005544	calcium-dependent phospholipid binding	IEA	molecular function
GO:0005544	calcium-dependent phospholipid binding	IDA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0005622	intracellular	IDA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0007599	hemostasis	IEA	biological process
GO:0008021	synaptic vesicle	IEA	cellular component
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0010033	response to organic substance	IEA	biological process
GO:0014704	intercalated disc	IEA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0017046	peptide hormone binding	IEA	molecular function
GO:0030018	Z disc	IEA	cellular component
GO:0030195	negative regulation of blood coagulation	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0030971	receptor tyrosine kinase binding	IEA	molecular function
GO:0042383	sarcolemma	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043066	negative regulation of apoptotic process	TAS	biological process
GO:0043086	negative regulation of catalytic activity	IEA	biological process
GO:0043204	perikaryon	IEA	cellular component
GO:0043679	axon terminus	IEA	cellular component
GO:0050819	negative regulation of coagulation	IEA	biological process
GO:0051260	protein homooligomerization	IEA	biological process
GO:0051592	response to calcium ion	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070588	calcium ion transmembrane transport	IEA	biological process
GO:0071284	cellular response to lead ion	IEA	biological process
GO:0072563	endothelial microparticle	IEA	cellular component
GO:0097066	response to thyroid hormone	IEA	biological process
GO:0097211	cellular response to gonadotropin-releasing hormone	IEA	biological process
GO:0098779	mitophagy in response to mitochondrial depolarization	IGI	biological process
GO:0098792	xenophagy	IMP	biological process
GO:1901317	regulation of flagellated sperm motility	IEA	biological process
GO:1902721	negative regulation of prolactin secretion	IEA	biological process
GO:0002230	positive regulation of defense response to virus by host	IMP	biological process
GO:0004859	phospholipase inhibitor activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005543	phospholipid binding	TAS	molecular function
GO:0005544	calcium-dependent phospholipid binding	IDA	molecular function
GO:0005622	intracellular	IDA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0016020	membrane	IDA	cellular component
GO:0043066	negative regulation of apoptotic process	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0098779	mitophagy in response to mitochondrial depolarization	IGI	biological process
GO:0098792	xenophagy	IMP	biological process

Diseases

Associated diseases	References
Cardiovascular disease	GAD: 16025836
Myocardial Infarction	GAD: 16025836
Venous thrombosis	GAD: 20174767
Hemorrhage	GAD: 20532885
Diabetes	GAD: 17554300
Metabolic syndrome	GAD: 19056482
Cerebral palsy	GAD: 18977990
Kidney diseases	GAD: 19578796
Preeclampsia	GAD: 17137622
Recurrent pregnancy loss (RPL)	GAD: 17339269
Pregnancy loss	GAD: 19652881
Recurrent pregnancy loss (RPL)	GAD: 17339269
Endometriosis	INFBASE: 22736326
Female infertility	INFBASE: 16768047
Asthenozoospermia	MIK: 20231113
Male factor infertility	MIK: 20231113
Chronic obstructive pulmonary disease (COPD)	GAD: 21685187
Pulmonary disease	GAD: 21685187
Femur head necrosis	GAD: 19345290
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Asthenozoospermia	MIK: 20231113
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
20231113	Asthenozoospermia			12 (6 healthy fertile men, 6 asthenozoospermia volunteers)	Male infertility	annexin VI isoform 2 isoform 1 of interleukin-6 receptor subunit beta precursor Mr 400 000 protein cytosolic dynein heavy chain alpha-actinin-4 receptor-type tyrosine-protein phosphatase eta precursor vitamin D-binding protein precursor protein S10
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray