• Gene id: 301

Gene Summary

• Gene Symbol: ANXA1   Gene   UCSC   Ensembl
• Aliases: ANX1, LPC1
• Gene name: annexin A1
• Alternate names: annexin A1, annexin I (lipocortin I), annexin-1, calpactin II, calpactin-2, chromobindin-9, epididymis secretory sperm binding protein, phospholipase A2 inhibitory protein,
• Gene location: 9q21.13 (73151864: 73170392)     Exons: 15     NC_000009.12
• Gene summary(Entrez): This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec
• OMIM: 151690

SNPs

rs2298090

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.26156845A>G
NC_000006.11   g.26157073A>G
NM_005321.2   c.455A>G
NM_005321.3   c.455A>G
NP_005312.1   p.Lys152Arg|SEQ=[A/G]|GENE=H1-4
H2BC5   3017

Protein Summary

• Protein general information: P04083  
  • Name: Annexin A1 (Annexin I) (Annexin 1) (Calpactin II) (Calpactin 2) (Chromobindin 9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)
  • Length: 346  
  • Mass: 38714
  • Tissue specificity: Detected in resting neutrophils (PubMed
• Sequence:

  MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNA
  QRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIR
  DINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTIL
  TTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM
  VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN

• Structural information:
  • Interpro: IPR001464  IPR018502  IPR018252  IPR037104  IPR002388  
  • Prosite: PS00223 PS51897
  • PDB: 1AIN 1BO9 1QLS 5VFW
  • PDBsum: 1AIN 1BO9 1QLS 5VFW
  • DIP: 32875
  • STRING: ENSP00000366109
• Other Databases: GeneCards:  ANXA1  Malacards:  ANXA1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005509	calcium ion binding	IBA	molecular function
GO:0005544	calcium-dependent phospholipid binding	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0006909	phagocytosis	IBA	biological process
GO:0008360	regulation of cell shape	IBA	biological process
GO:0010165	response to X-ray	IBA	biological process
GO:0019834	phospholipase A2 inhibitor activity	IBA	molecular function
GO:0030073	insulin secretion	IBA	biological process
GO:0030850	prostate gland development	IBA	biological process
GO:0031394	positive regulation of prostaglandin biosynthetic process	IBA	biological process
GO:0032355	response to estradiol	IBA	biological process
GO:0032508	DNA duplex unwinding	IBA	biological process
GO:0032652	regulation of interleukin-1 production	IBA	biological process
GO:0032743	positive regulation of interleukin-2 production	IBA	biological process
GO:0042127	regulation of cell population proliferation	IBA	biological process
GO:0045629	negative regulation of T-helper 2 cell differentiation	IBA	biological process
GO:0045920	negative regulation of exocytosis	IBA	biological process
GO:0046632	alpha-beta T cell differentiation	IBA	biological process
GO:0050727	regulation of inflammatory response	IBA	biological process
GO:0070555	response to interleukin-1	IBA	biological process
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IBA	biological process
GO:0090303	positive regulation of wound healing	IBA	biological process
GO:0097350	neutrophil clearance	IBA	biological process
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IBA	biological process
GO:0002685	regulation of leukocyte migration	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0006954	inflammatory response	IBA	biological process
GO:0007166	cell surface receptor signaling pathway	IBA	biological process
GO:0014839	myoblast migration involved in skeletal muscle regeneration	IBA	biological process
GO:0030216	keratinocyte differentiation	IBA	biological process
GO:0031018	endocrine pancreas development	IBA	biological process
GO:0031340	positive regulation of vesicle fusion	IBA	biological process
GO:0031532	actin cytoskeleton reorganization	IBA	biological process
GO:0033031	positive regulation of neutrophil apoptotic process	IBA	biological process
GO:0035924	cellular response to vascular endothelial growth factor stimulus	IBA	biological process
GO:0042063	gliogenesis	IBA	biological process
GO:0042102	positive regulation of T cell proliferation	IBA	biological process
GO:0042493	response to drug	IBA	biological process
GO:0043434	response to peptide hormone	IBA	biological process
GO:0044849	estrous cycle	IBA	NOT|biological process
GO:0045627	positive regulation of T-helper 1 cell differentiation	IBA	biological process
GO:0046883	regulation of hormone secretion	IBA	biological process
GO:0050482	arachidonic acid secretion	IBA	biological process
GO:0070301	cellular response to hydrogen peroxide	IBA	biological process
GO:0070365	hepatocyte differentiation	IBA	biological process
GO:0070459	prolactin secretion	IBA	biological process
GO:0071385	cellular response to glucocorticoid stimulus	IBA	biological process
GO:0071621	granulocyte chemotaxis	IBA	biological process
GO:1900138	negative regulation of phospholipase A2 activity	IBA	biological process
GO:2000483	negative regulation of interleukin-8 secretion	IBA	biological process
GO:0008360	regulation of cell shape	IDA	biological process
GO:0031532	actin cytoskeleton reorganization	IDA	biological process
GO:0071621	granulocyte chemotaxis	IDA	biological process
GO:0002548	monocyte chemotaxis	IDA	biological process
GO:0032743	positive regulation of interleukin-2 production	IDA	biological process
GO:0045629	negative regulation of T-helper 2 cell differentiation	IDA	biological process
GO:0019898	extrinsic component of membrane	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0031232	extrinsic component of external side of plasma membrane	IDA	cellular component
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA	biological process
GO:0090303	positive regulation of wound healing	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0042102	positive regulation of T cell proliferation	IDA	biological process
GO:0045627	positive regulation of T-helper 1 cell differentiation	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP	biological process
GO:0031901	early endosome membrane	ISS	cellular component
GO:0031313	extrinsic component of endosome membrane	ISS	cellular component
GO:0005509	calcium ion binding	ISS	molecular function
GO:0016328	lateral plasma membrane	ISS	cellular component
GO:0050727	regulation of inflammatory response	ISS	biological process
GO:0032652	regulation of interleukin-1 production	ISS	biological process
GO:0006909	phagocytosis	ISS	biological process
GO:0045920	negative regulation of exocytosis	IMP	biological process
GO:0031514	motile cilium	ISS	cellular component
GO:0016324	apical plasma membrane	ISS	cellular component
GO:0006954	inflammatory response	ISS	biological process
GO:0002685	regulation of leukocyte migration	ISS	biological process
GO:0046883	regulation of hormone secretion	IMP	biological process
GO:0004859	phospholipase inhibitor activity	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005544	calcium-dependent phospholipid binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0002376	immune system process	IEA	biological process
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005544	calcium-dependent phospholipid binding	IEA	molecular function
GO:0019834	phospholipase A2 inhibitor activity	IEA	molecular function
GO:0045087	innate immune response	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0002250	adaptive immune response	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005509	calcium ion binding	TAS	molecular function
GO:0005102	signaling receptor binding	TAS	molecular function
GO:0005543	phospholipid binding	TAS	molecular function
GO:0006954	inflammatory response	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IEA	biological process
GO:0050727	regulation of inflammatory response	IEA	biological process
GO:0046632	alpha-beta T cell differentiation	IEA	biological process
GO:0042127	regulation of cell population proliferation	IEA	biological process
GO:0032652	regulation of interleukin-1 production	IEA	biological process
GO:0016328	lateral plasma membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0006909	phagocytosis	IEA	biological process
GO:0001780	neutrophil homeostasis	IEA	biological process
GO:1990814	DNA/DNA annealing activity	IEA	molecular function
GO:0070555	response to interleukin-1	IEA	biological process
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0042629	mast cell granule	IEA	cellular component
GO:0032991	protein-containing complex	IEA	cellular component
GO:0032508	DNA duplex unwinding	IEA	biological process
GO:0032355	response to estradiol	IEA	biological process
GO:0031394	positive regulation of prostaglandin biosynthetic process	IEA	biological process
GO:0030850	prostate gland development	IEA	biological process
GO:0030073	insulin secretion	IEA	biological process
GO:0019834	phospholipase A2 inhibitor activity	IEA	molecular function
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0010165	response to X-ray	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0071385	cellular response to glucocorticoid stimulus	IEA	biological process
GO:0050482	arachidonic acid secretion	IEA	biological process
GO:0042383	sarcolemma	IEA	cellular component
GO:0033031	positive regulation of neutrophil apoptotic process	IEA	biological process
GO:0031514	motile cilium	IEA	cellular component
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0014839	myoblast migration involved in skeletal muscle regeneration	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0002685	regulation of leukocyte migration	IEA	biological process
GO:1900138	negative regulation of phospholipase A2 activity	IEA	biological process
GO:0097060	synaptic membrane	IEA	cellular component
GO:0071385	cellular response to glucocorticoid stimulus	IEA	biological process
GO:0070459	prolactin secretion	IEA	biological process
GO:0070365	hepatocyte differentiation	IEA	biological process
GO:0070301	cellular response to hydrogen peroxide	IEA	biological process
GO:0050709	negative regulation of protein secretion	IEA	biological process
GO:0043434	response to peptide hormone	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0042493	response to drug	IEA	biological process
GO:0042063	gliogenesis	IEA	biological process
GO:0036121	double-stranded DNA helicase activity	IEA	molecular function
GO:0031966	mitochondrial membrane	IEA	cellular component
GO:0031960	response to corticosteroid	IEA	biological process
GO:0031018	endocrine pancreas development	IEA	biological process
GO:0009725	response to hormone	IEA	biological process
GO:0007166	cell surface receptor signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005543	phospholipid binding	IEA	molecular function
GO:0003727	single-stranded RNA binding	IEA	molecular function
GO:0003697	single-stranded DNA binding	IEA	molecular function
GO:0035924	cellular response to vascular endothelial growth factor stimulus	IDA	biological process
GO:0005884	actin filament	IDA	colocalizes with
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:2000483	negative regulation of interleukin-8 secretion	IMP	biological process
GO:0019834	phospholipase A2 inhibitor activity	IDA	molecular function
GO:0098641	cadherin binding involved in cell-cell adhesion	HDA	molecular function
GO:0001780	neutrophil homeostasis	IMP	biological process
GO:0046632	alpha-beta T cell differentiation	ISS	biological process
GO:0097350	neutrophil clearance	IMP	biological process
GO:0071385	cellular response to glucocorticoid stimulus	IDA	biological process
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IDA	biological process
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005912	adherens junction	HDA	cellular component
GO:0016328	lateral plasma membrane	IEA	cellular component
GO:0001891	phagocytic cup	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0016323	basolateral plasma membrane	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0030659	cytoplasmic vesicle membrane	IEA	cellular component
GO:0005769	early endosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0010008	endosome membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0048306	calcium-dependent protein binding	IPI	molecular function
GO:0098609	cell-cell adhesion	IEA	biological process
GO:0005768	endosome	IDA	cellular component
GO:0019834	phospholipase A2 inhibitor activity	IDA	molecular function
GO:0005544	calcium-dependent phospholipid binding	IDA	molecular function
GO:0031340	positive regulation of vesicle fusion	IDA	biological process
GO:0030216	keratinocyte differentiation	IDA	biological process
GO:0018149	peptide cross-linking	IDA	biological process
GO:0001533	cornified envelope	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0031982	vesicle	HDA	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005615	extracellular space	HDA	cellular component
GO:0005615	extracellular space	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0043066	negative regulation of apoptotic process	TAS	biological process
GO:0007165	signal transduction	TAS	biological process

Diseases

Associated diseases	References
Ductal carcinoma in situ	PMID:22323911
Dry eye syndrome	PMID:23201116
paranasal sinus neoplasm	PMID:20970165
Squamous cell carcinoma	PMID:8919037
pancreatic cancer	PMID:17974280
pancreatic cancer	PMID:19173988
Brain ischemia	PMID:1830327
Keratosis follicularis	PMID:8919037
invasive ductal carcinoma	PMID:18776816
invasive ductal carcinoma	PMID:19171478
Astrocytoma	PMID:20133820
Seborrheic keratosis	PMID:8919037
Psoriasis	PMID:8919037
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)