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Gene id 3007
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol H1-3   Gene   UCSC   Ensembl
Aliases H1.3, H1D, H1F3, H1s-2, HIST1H1D
Gene name H1.3 linker histone, cluster member
Alternate names histone H1.3, H1 histone family, member 3, histone 1, H1d, histone H1c, histone H1s-2, histone cluster 1 H1 family member d, histone cluster 1, H1d,
Gene location 6p22.2 (26234986: 26234211)     Exons: 1     NC_000006.12
Gene summary(Entrez) Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in
OMIM 612384

Protein Summary

Protein general information P16402  

Name: Histone H1.3 (Histone H1c) (Histone H1s 2)

Length: 221  Mass: 22350

Sequence MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVE
KNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKK
SIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK
Structural information
Protein Domains
(37..11-)
(/note="H15-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00837"-)
Interpro:  IPR005818  IPR005819  IPR036388  IPR036390  
Prosite:   PS51504
CDD:   cd00073
MINT:  
STRING:   ENSP00000244534
Other Databases GeneCards:  H1-3  Malacards:  H1-3

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0031490 chromatin DNA binding
IDA molecular function
GO:0005719 nuclear euchromatin
IDA cellular component
GO:0000790 nuclear chromatin
IDA cellular component
GO:0003723 RNA binding
HDA molecular function
GO:0000786 nucleosome
IEA cellular component
GO:0006334 nucleosome assembly
IEA biological process
GO:0042025 host cell nucleus
IEA cellular component
GO:0003677 DNA binding
IEA molecular function
GO:0045910 negative regulation of DN
A recombination
IBA biological process
GO:0031492 nucleosomal DNA binding
IBA molecular function
GO:0030261 chromosome condensation
IBA biological process
GO:0003690 double-stranded DNA bindi
ng
IBA molecular function
GO:0031936 negative regulation of ch
romatin silencing
IBA biological process
GO:0016584 nucleosome positioning
IBA biological process
GO:0006355 regulation of transcripti
on, DNA-templated
IBA biological process
GO:0005719 nuclear euchromatin
IBA cellular component
GO:0005634 nucleus
IBA cellular component
GO:0000790 nuclear chromatin
IBA cellular component
GO:0005634 nucleus
IEA cellular component
GO:0005694 chromosome
IEA cellular component
GO:0003677 DNA binding
IEA molecular function
GO:0006357 regulation of transcripti
on by RNA polymerase II
IEA biological process
GO:0080182 histone H3-K4 trimethylat
ion
IEA biological process
GO:0000122 negative regulation of tr
anscription by RNA polyme
rase II
IEA biological process
GO:0003677 DNA binding
IEA molecular function
GO:0016584 nucleosome positioning
IEA biological process
GO:0098532 histone H3-K27 trimethyla
tion
IEA biological process
GO:0005634 nucleus
IEA cellular component
GO:0005694 chromosome
IEA cellular component
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract