Gene id |
3007 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
H1-3 Gene UCSC Ensembl |
Aliases |
H1.3, H1D, H1F3, H1s-2, HIST1H1D |
Gene name |
H1.3 linker histone, cluster member |
Alternate names |
histone H1.3, H1 histone family, member 3, histone 1, H1d, histone H1c, histone H1s-2, histone cluster 1 H1 family member d, histone cluster 1, H1d, |
Gene location |
6p22.2 (26234986: 26234211) Exons: 1 NC_000006.12
|
Gene summary(Entrez) |
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in
|
OMIM |
612384 |
Protein Summary
|
Protein general information
| P16402
Name: Histone H1.3 (Histone H1c) (Histone H1s 2)
Length: 221 Mass: 22350
|
Sequence |
MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVE KNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKK SIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK
|
Structural information |
|
Other Databases |
GeneCards: H1-3  Malacards: H1-3 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0031490 |
chromatin DNA binding
|
IDA |
molecular function |
GO:0005719 |
nuclear euchromatin
|
IDA |
cellular component |
GO:0000790 |
nuclear chromatin
|
IDA |
cellular component |
GO:0003723 |
RNA binding
|
HDA |
molecular function |
GO:0000786 |
nucleosome
|
IEA |
cellular component |
GO:0006334 |
nucleosome assembly
|
IEA |
biological process |
GO:0042025 |
host cell nucleus
|
IEA |
cellular component |
GO:0003677 |
DNA binding
|
IEA |
molecular function |
GO:0045910 |
negative regulation of DN A recombination
|
IBA |
biological process |
GO:0031492 |
nucleosomal DNA binding
|
IBA |
molecular function |
GO:0030261 |
chromosome condensation
|
IBA |
biological process |
GO:0003690 |
double-stranded DNA bindi ng
|
IBA |
molecular function |
GO:0031936 |
negative regulation of ch romatin silencing
|
IBA |
biological process |
GO:0016584 |
nucleosome positioning
|
IBA |
biological process |
GO:0006355 |
regulation of transcripti on, DNA-templated
|
IBA |
biological process |
GO:0005719 |
nuclear euchromatin
|
IBA |
cellular component |
GO:0005634 |
nucleus
|
IBA |
cellular component |
GO:0000790 |
nuclear chromatin
|
IBA |
cellular component |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005694 |
chromosome
|
IEA |
cellular component |
GO:0003677 |
DNA binding
|
IEA |
molecular function |
GO:0006357 |
regulation of transcripti on by RNA polymerase II
|
IEA |
biological process |
GO:0080182 |
histone H3-K4 trimethylat ion
|
IEA |
biological process |
GO:0000122 |
negative regulation of tr anscription by RNA polyme rase II
|
IEA |
biological process |
GO:0003677 |
DNA binding
|
IEA |
molecular function |
GO:0016584 |
nucleosome positioning
|
IEA |
biological process |
GO:0098532 |
histone H3-K27 trimethyla tion
|
IEA |
biological process |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005694 |
chromosome
|
IEA |
cellular component |
|
|
Associated diseases |
References |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|