• Gene id: 29984

Gene Summary

• Gene Symbol: RHOD   Gene   UCSC   Ensembl
• Aliases: ARHD, RHOHP1, RHOM, Rho
• Gene name: ras homolog family member D
• Alternate names: rho-related GTP-binding protein RhoD, Rho-related protein HP1, ras homolog D, ras homolog gene family, member A, ras homolog gene family, member D,
• Gene location: 11q13.2 (19178862: 19175574)     Exons: 10     NC_000022.11
• Gene summary(Entrez): Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It
• OMIM: 605781

Protein Summary

• Protein general information: O00212  
  • Name: Rho related GTP binding protein RhoD (Rho related protein HP1) (RhoHP1)
  • Length: 210  
  • Mass: 23413
  • Tissue specificity: Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
• Sequence:

  MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQ
  DDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLCKDKSLVNKLRRNGLEP
  VTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT

• Structural information:
  • Interpro: IPR027417  IPR005225  IPR001806  IPR003578  
  • Prosite: PS51420
  • PDB: 2J1L
  • PDBsum: 2J1L
  • STRING: ENSP00000308576
• Other Databases: GeneCards:  RHOD  Malacards:  RHOD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0003924	GTPase activity	IBA	molecular function
GO:0005525	GTP binding	IBA	molecular function
GO:0016477	cell migration	IBA	biological process
GO:0030335	positive regulation of cell migration	IMP	biological process
GO:0030032	lamellipodium assembly	IMP	biological process
GO:0048041	focal adhesion assembly	IMP	biological process
GO:0045785	positive regulation of cell adhesion	IMP	biological process
GO:0051017	actin filament bundle assembly	IMP	biological process
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0007264	small GTPase mediated signal transduction	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0005525	GTP binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0003924	GTPase activity	TAS	molecular function
GO:0007266	Rho protein signal transduction	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	biological process
GO:0006605	protein targeting	IEA	biological process
GO:0005525	GTP binding	IEA	molecular function
GO:2000249	regulation of actin cytoskeleton reorganization	IEA	biological process
GO:0051893	regulation of focal adhesion assembly	IEA	biological process
GO:0019901	protein kinase binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005769	early endosome	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881