• Gene id: 29980

Gene Summary

• Gene Symbol: DONSON   Gene   UCSC   Ensembl
• Aliases: B17, C21orf60, MIMIS, MISSLA
• Gene name: DNA replication fork stabilization factor DONSON
• Alternate names: protein downstream neighbor of Son, downstream neighbor of SON,
• Gene location: 21q22.11 (33588683: 33577550)     Exons: 10     NC_000021.9
• Gene summary(Entrez): This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
• OMIM: 100690

Protein Summary

• Protein general information: Q9NYP3  
  • Name: Protein downstream neighbor of Son (B17)
  • Length: 566  
  • Mass: 62747
  • Tissue specificity: Expressed in the brain, with higher levels in prenatal compared to adult brain. {ECO
• Sequence:

  MALSVPGYSPGFRKPPEVVRLRRKRARSRGAAASPPRELTEPAARRAALVAGLPLRPFPAAGGRGGGSGGGPAAA
  RRNPFARLDNRPRVAAEPPDGPAREQPEAPVPFLDSNQENDLLWEEKFPERTTVTELPQTSHVSFSEPDIPSSKS
  TELPVDWSIKTRLLFTSSQPFTWADHLKAQEEAQGLVQHCRATEVTLPKSIQDPKLSSELRCTFQQSLIYWLHPA
  LSWLPLFPRIGADRKMAGKTSPWSNDATLQHVLMSDWSVSFTSLYNLLKTKLCPYFYVCTYQFTVLFRAAGLAGS
  DLITALISPTTRGLREAMRNEGIEFSLPLIKESGHKKETASGTSLGYGEEQAISDEDEEESFSWLEEMGVQDKIK
  KPDILSIKLRKEKHEVQMDHRPESVVLVKGINTFTLLNFLINSKSLVATSGPQAGLPPTLLSPVAFRGATMQMLK
  ARSVNVKTQALSGYRDQFSLEITGPIMPHSLHSLTMLLKSSQSGSFSAVLYPHEPTAVFNICLQMDKVLDMEVVH
  KELTNCGLHPNTLEQLSQIPLLGKSSLRNVVLRDYIYNWRS

• Structural information:
  • Interpro: IPR024861  
  • STRING: ENSP00000307143
• Other Databases: GeneCards:  DONSON  Malacards:  DONSON

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0033260	nuclear DNA replication	IBA	biological process
GO:0030894	replisome	IDA	cellular component
GO:0005657	replication fork	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0007095	mitotic G2 DNA damage checkpoint	IMP	biological process
GO:0048478	replication fork protection	IMP	biological process
GO:0006260	DNA replication	IMP	biological process
GO:0000077	DNA damage checkpoint	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Microcephaly syndrome	KEGG:H02132
Microcephaly syndrome	KEGG:H02132
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R