• Gene id: 29965

Gene Summary

• Gene Symbol: CDIP1   Gene   UCSC   Ensembl
• Aliases: C16orf5, CDIP, I1, LITAFL
• Gene name: cell death inducing p53 target 1
• Alternate names: cell death-inducing p53-target protein 1, LITAF-like protein, cell death inducing protein, cell death involved p53-target, lipopolysaccharide-induced tumor necrosis factor-alpha-like protein, transmembrane protein I1,
• Gene location: 16p13.3 (4538772: 4510668)     Exons: 7     NC_000016.10
• OMIM: 184430

Protein Summary

• Protein general information: Q9H305  
  • Name: Cell death inducing p53 target protein 1 (Cell death involved p53 target) (Cell death inducing protein) (LITAF like protein) (Lipopolysaccharide induced tumor necrosis factor alpha like protein) (Transmembrane protein I1)
  • Length: 208  
  • Mass: 21892
  • Tissue specificity: Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung. {ECO
• Sequence:

  MSSEPPPPYPGGPTAPLLEEKSGAPPTPGRSSPAVMQPPPGMPLPPADIGPPPYEPPGHPMPQPGFIPPHMSADG
  TYMPPGFYPPPGPHPPMGYYPPGPYTPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAIT
  TKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC

• Structural information:
  • Protein Domains: (122..20-)
    (/note="LITAF-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01181"-)
  • Interpro: IPR006629  IPR037519  
  • Prosite: PS51837
  • STRING: ENSP00000382508
• Other Databases: GeneCards:  CDIP1  Malacards:  CDIP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0098574	cytoplasmic side of lysosomal membrane	IDA	cellular component
GO:0098560	cytoplasmic side of late endosome membrane	IDA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	biological process
GO:0033209	tumor necrosis factor-mediated signaling pathway	IGI	biological process
GO:0006915	apoptotic process	IGI	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0031902	late endosome membrane	IEA	cellular component
GO:0005634	nucleus	NAS	cellular component
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)