• Gene id: 29888

Gene Summary

• Gene Symbol: STRN4   Gene   UCSC   Ensembl
• Aliases: PPP2R6C, ZIN, zinedin
• Gene name: striatin 4
• Alternate names: striatin-4, protein phosphatase 2 regulatory subunit B'''gamma, striatin, calmodulin binding protein 4,
• Gene location: 19q13.32 (46746474: 46719508)     Exons: 23     NC_000019.10
• OMIM: 614767

Protein Summary

• Protein general information: Q9NRL3  
  • Name: Striatin 4 (Zinedin)
  • Length: 753  
  • Mass: 80596
• Sequence:

  MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGPEPLSLPGILHFIQHE
  WARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADV
  SEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPG
  PAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
  PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADLRDVDGLPPKVTGPPP
  GTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQ
  SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSM
  DPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS
  TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSM
  VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAK
  VFV

• Structural information:
  • Interpro: IPR020472  IPR013258  IPR015943  IPR001680  IPR019775   IPR017986  IPR036322  
  • Prosite: PS00678 PS50082 PS50294
  • STRING: ENSP00000375777
• Other Databases: GeneCards:  STRN4  Malacards:  STRN4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070016	armadillo repeat domain binding	IBA	molecular function
GO:0030425	dendrite	IBA	cellular component
GO:0005516	calmodulin binding	IBA	molecular function
GO:0051721	protein phosphatase 2A binding	IBA	molecular function
GO:0044877	protein-containing complex binding	IBA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0032991	protein-containing complex	IEA	cellular component
GO:0019904	protein domain specific binding	IEA	molecular function
GO:0043197	dendritic spine	IEA	cellular component
GO:0044877	protein-containing complex binding	IEA	molecular function
GO:0043197	dendritic spine	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0051721	protein phosphatase 2A binding	IDA	molecular function
GO:0044877	protein-containing complex binding	IDA	molecular function
GO:0090443	FAR/SIN/STRIPAK complex	IDA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0070016	armadillo repeat domain binding	IPI	molecular function
GO:0005516	calmodulin binding	NAS	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray