• Gene id: 29883

Gene Summary

• Gene Symbol: CNOT7   Gene   UCSC   Ensembl
• Aliases: CAF-1, CAF1, Caf1a, hCAF-1
• Gene name: CCR4-NOT transcription complex subunit 7
• Alternate names: CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, carbon catabolite repressor protein (CCR4)-associative factor 1,
• Gene location: 8p22 (17246908: 17221980)     Exons: 12     NC_000014.9
• Gene summary(Entrez): The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, caus
• OMIM: 604913

KEGG pathways

Pathway id	Pathway name
hsa03018	RNA degradation

Diseases

Associated diseases	References
Abnormal sperm morphology caused by defects in Sertoli cells	MIK: 15700538
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Abnormal sperm morphology caused by defects in Sertoli cells	MIK: 15700538
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
15700538	Abnormal sperm morphology caused by defects in Sertoli cells				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray