• Gene id: 29766

Gene Summary

• Gene Symbol: TMOD3   Gene   UCSC   Ensembl
• Aliases: UTMOD
• Gene name: tropomodulin 3
• Alternate names: tropomodulin-3, tropomodulin 3 (ubiquitous), ubiquitous tropomodulin,
• Gene location: 15q21.2 (51829652: 51915724)     Exons: 12     NC_000015.10
• OMIM: 605112

Protein Summary

• Protein general information: Q9NYL9  
  • Name: Tropomodulin 3 (Ubiquitous tropomodulin) (U Tmod)
  • Length: 352  
  • Mass: 39595
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MALPFRKDLEKYKDLDEDELLGNLSETELKQLETVLDDLDPENALLPAGFRQKNQTSKSTTGPFDREHLLSYLEK
  EALEHKDREDYVPYTGEKKGKIFIPKQKPVQTFTEEKVSLDPELEEALTSASDTELCDLAAILGMHNLITNTKFC
  NIMGSSNGVDQEHFSNVVKGEKILPVFDEPPNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKDFAKALET
  NTHVKCFSLAATRSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDALRDNETLAELKIDNQRQQLGTA
  VELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRVEGDHQ

• Structural information:
  • Interpro: IPR032675  IPR004934  IPR030133  
  • STRING: ENSP00000308753
• Other Databases: GeneCards:  TMOD3  Malacards:  TMOD3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007015	actin filament organization	IBA	biological process
GO:0005865	striated muscle thin filament	IBA	cellular component
GO:0005523	tropomyosin binding	IBA	molecular function
GO:0030239	myofibril assembly	IBA	biological process
GO:0030016	myofibril	IBA	cellular component
GO:0006936	muscle contraction	IBA	biological process
GO:0005856	cytoskeleton	IBA	cellular component
GO:0005523	tropomyosin binding	IEA	molecular function
GO:0030036	actin cytoskeleton organization	IEA	biological process
GO:0048821	erythrocyte development	IEA	biological process
GO:0051694	pointed-end actin filament capping	IEA	biological process
GO:0003779	actin binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005523	tropomyosin binding	TAS	molecular function
GO:0005523	tropomyosin binding	IEA	molecular function
GO:0005865	striated muscle thin filament	IEA	cellular component
GO:0030036	actin cytoskeleton organization	IEA	biological process
GO:0048821	erythrocyte development	IEA	biological process
GO:1901992	positive regulation of mitotic cell cycle phase transition	IEA	biological process
GO:0098641	cadherin binding involved in cell-cell adhesion	HDA	molecular function
GO:0005912	adherens junction	HDA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0098609	cell-cell adhesion	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R