• Gene id: 29765

Gene Summary

• Gene Symbol: TMOD4   Gene   UCSC   Ensembl
• Aliases: SK-TMOD
• Gene name: tropomodulin 4
• Alternate names: tropomodulin-4, actin-capping protein, skeletal muscle tropomodulin, skeletal tropomodulin, tropomodulin 4 (muscle),
• Gene location: 1q21.3 (151175980: 151169985)     Exons: 10     NC_000001.11
• OMIM: 606556

Protein Summary

• Protein general information: Q9NZQ9  
  • Name: Tropomodulin 4 (Skeletal muscle tropomodulin) (Sk Tmod)
  • Length: 345  
  • Mass: 39335
  • Tissue specificity: Highly expressed in skeletal muscle. {ECO
• Sequence:

  MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDREALLQYLEQQ
  ALEVKERDDLVPFTGEKKGKPYIQPKREIPAEEQITLEPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDAL
  CSGEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTY
  VRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWPGDAVEM
  EMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKKR

• Structural information:
  • Interpro: IPR032675  IPR004934  IPR030129  
  • STRING: ENSP00000295314
• Other Databases: GeneCards:  TMOD4  Malacards:  TMOD4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005523	tropomyosin binding	IBA	molecular function
GO:0005865	striated muscle thin filament	IBA	cellular component
GO:0007015	actin filament organization	IBA	biological process
GO:0005856	cytoskeleton	IBA	cellular component
GO:0006936	muscle contraction	IBA	biological process
GO:0030016	myofibril	IBA	cellular component
GO:0030239	myofibril assembly	IBA	biological process
GO:0005523	tropomyosin binding	IEA	molecular function
GO:0051015	actin filament binding	IEA	molecular function
GO:0051694	pointed-end actin filament capping	IEA	biological process
GO:0003779	actin binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005523	tropomyosin binding	TAS	molecular function
GO:0006936	muscle contraction	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005865	striated muscle thin filament	IEA	cellular component
GO:0005523	tropomyosin binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005865	striated muscle thin filament	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray