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Gene id 2952
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol GSTT1   Gene   UCSC   Ensembl
Gene name glutathione S-transferase theta 1
Alternate names glutathione S-transferase theta-1, GST class-theta-1, glutathione transferase T1-1,
Gene location 22q11.23 (95435071: 95404861)     Exons: 9     NC_000007.14
Gene summary(Entrez) The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be div
OMIM 600436

Protein Summary
Protein general information P30711  

Name: Glutathione S transferase theta 1 (EC 2.5.1.18) (GST class theta 1) (Glutathione transferase T1 1)

Length: 240  Mass: 27,335

Sequence MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAILLYLT
RKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDK
FLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADP
TIKQKLMPWVLAMIR
Structural information
Protein Domains
 GST (2-82)
GST (88-220)
Interpro:  IPR010987  IPR036282  IPR004045  IPR004046  IPR036249  
Prosite:   PS50405 PS50404

PDB:  		 2C3N 2C3Q 2C3T
PDBsum:   2C3N 2C3Q 2C3T
STRING:   ENSP00000248935
Other Databases GeneCards:  GSTT1  Malacards:  GSTT1

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 TAS molecular function
GO:0004602 glutathione peroxidase ac
tivity
 IDA molecular function
GO:0004602 glutathione peroxidase ac
tivity
 IDA molecular function
GO:0005829 cytosol
 IDA cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0070062 extracellular exosome
 IDA cellular component
GO:0070062 extracellular exosome
 IDA cellular component
GO:0098869 cellular oxidant detoxifi
cation
 IEA biological process
GO:1901687 glutathione derivative bi
osynthetic process
 TAS biological process
GO:0004364 glutathione transferase a
ctivity
 IEA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 TAS molecular function
GO:0004602 glutathione peroxidase ac
tivity
 IDA molecular function
GO:0004602 glutathione peroxidase ac
tivity
 IDA molecular function
GO:0005737 cytoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005829 cytosol
 IDA cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0016740 transferase activity
 IEA molecular function
GO:0070062 extracellular exosome
 IDA cellular component
GO:0070062 extracellular exosome
 IDA cellular component
GO:0098869 cellular oxidant detoxifi
cation
 IEA biological process
GO:1901687 glutathione derivative bi
osynthetic process
 TAS biological process
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 IDA molecular function
GO:0004364 glutathione transferase a
ctivity
 TAS molecular function
GO:0004602 glutathione peroxidase ac
tivity
 IDA molecular function
GO:0004602 glutathione peroxidase ac
tivity
 IDA molecular function
GO:0005829 cytosol
 IDA cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0006749 glutathione metabolic pro
cess
 IDA biological process
GO:0070062 extracellular exosome
 IDA cellular component
GO:0070062 extracellular exosome
 IDA cellular component
GO:1901687 glutathione derivative bi
osynthetic process
 TAS biological process

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa01100Metabolic pathways
hsa05200Pathways in cancer
hsa05204Chemical carcinogenesis
hsa05225Hepatocellular carcinoma
hsa05418Fluid shear stress and atherosclerosis
hsa01524Platinum drug resistance

Diseases

Expand All | Collapse All
Associated diseases References
Astrocytoma GAD: 15102663
Leukoplakia GAD: 18507060
Cancer (thyroid) GAD: 17158763
Cancer (transitional cell) GAD: 15548945
Cancer (urinary bladder) GAD: 19467981
Cancer (uterine cervical) GAD: 18177825
Brill-Symmers disease GAD: 20029944
Cancer GAD: 20056567
Cancer (Adenocarcinoma) GAD: 18779738
Cancer (Adenoma) GAD: 19589345
Cancer (Aerodigestive tract) GAD: 20012094
Cancer (basal cell) GAD: 19800766
Cancer (bladder) GAD: 16112301
Cancer (brain) GAD: 17372252
Cancer (Cerebellar) GAD: 18952980
Cancer (cervical) GAD: 19012698
Cancer (Chronic B-Cell Leukemias) GAD: 12010828
Cancer (colon) GAD: 12210502
Cancer (colorectal) GAD: 12419832
Cancer (endometrial) GAD: 20381444
Cancer (esophageal) GAD: 12883749
Cancer (gallbladder) GAD: 16760134
Cancer (gastric) GAD: 19521675
Cancer (germinoma) GAD: 19741569
Cancer (glaucoma) GAD: 11040079
Cancer (glioma) GAD: 20391338
Cancer (head and neck) GAD: 12548461
Cancer (Hepatocellular) GAD: 11440964
Cancer (Hodgkin disease) GAD: 15368334
Cancer (kidney) GAD: 17617661
Cancer (laryngeal) GAD: 12668919
Cancer (leukemia) GAD: 15981231
Cancer (liver) GAD: 15734960
Cancer (lung) GAD: 12234692
Cancer (lymphoma) GAD: 15725081
Cancer (melanoma) GAD: 17072629
Cancer (mesothelioma) GAD: 16697254
Cancer (mouth) GAD: 11564581
Cancer (myeloid leukemia) GAD: 19811334
Cancer (myeloma) GAD: 15136237
Cancer (nasopharyngeal) GAD: 15634519
Cancer (Neuroblastoma) GAD: 15900216
Cancer (non-Hodgkin lymphoma) GAD: 12139735
Cancer (non-melanoma skin cancer) GAD: 15459020
Cancer (oral) GAD: 16393248
Cancer (oropharyngeal) GAD: 12029283
Cancer (ovarian) GAD: 16710704
Cancer (pancreatic) GAD: 12183419
Cancer (Papilary) GAD: 18591888
Cancer (papillary thyroid cancer) GAD: 19629346
Cancer (prostate) GAD: 14719475
Cancer (Renal cell) GAD: 18566013
Cancer (soft tissue sarcoma) GAD: 15459223
Cancer (Squamous cell) GAD: 18507050
Cancer (stomach) GAD: 11692073
Cancer (testicular) GAD: 18162130
Cancer (breast) GAD: 11291049
Atherosclerosis GAD: 11259393
Atherosclerosis GAD: 12355548
Cardiovascular disease GAD: 15927971
Hypertension GAD: 18840420
Brain ischemia GAD: 12663932
Intrauterine growth retardation GAD: 14665706
Limb deficiency defects GAD: 16906563
Neuropathy GAD: 15838728
Down syndrome GAD: 19491810
Cystic fibrosis GAD: 15115915
Cleft defects GAD: 16521944
Cleft defects GAD: 16521944
Esophageal atresia GAD: 20740495
Gastric disease GAD: 15734972
Hepatic Veno-Occlusive disease GAD: 18641537
Graves disease GAD: 17980001
Diabetic neuropathy GAD: 15125229
Optic nerve diseases GAD: 19286687
Exfoliation syndrome GAD: 18334963
Glaucoma GAD: 11040079
Macular degeneration GAD: 16496253
Retinopathy GAD: 21038299
Eye diseases GAD: 18447907
Anemia GAD: 11488937
Fanconi anemia GAD: 16173971
Beta-thalassemia GAD: 16798650
Myelodysplastic syndrome GAD: 16620556
Neutropenia GAD: 19074750
Hodgkin disease GAD: 18768784
Asthma GAD: 12018173
Chronic ulcerative colitis GAD: 20459366
Inflammatory bowel disease GAD: 17565649
Multiple sclerosis GAD: 17437619
Psoriasis GAD: 12713578
Systemic lupus erythematosus (SLE) GAD: 11477481
Behcet's disease GAD: 16283344
Crohn's disease GAD: 12631667
Hypersensitivity GAD: 14726165
Diabetes GAD: 12732844
Fatty liver GAD: 18492019
Obesity GAD: 19057702
Biliary cirrhosis GAD: 15559321
Dyslipidemias GAD: 18254710
Bone diseases GAD: 16520888
Tardive dyskinesia GAD: 16160620
Motor neuron disease GAD: 12500684
Peripheral nervous system diseases GAD: 19223573
Alzheimer's disease GAD: 15805147
Epilepsy GAD: 18155166
Parkinson disease GAD: 15279067
Arthritis GAD: 12421093
Hearing Loss GAD: 17228018
Dyspepsia GAD: 18365908
Psychological disorders GAD: 18325667
Schizophrenia GAD: 18449862
Cognitive function GAD: 19057715
Chronic renal failure GAD: 18067039
Abortion GAD: 12606593
Chorioamnionitis GAD: 18320229
Polycystic ovary syndrome (PCOS) GAD: 15333250
Hypospadias GAD: 15579657
Varicocele GAD: 19151739
Fetal Growth Retardation GAD: 19440446
Oligozoospermia GAD: 17569254
Miscarriage GAD: 19892789
Preeclampsia GAD: 11751440
Pregnancy complications GAD: 20301895
Premature birth GAD: 18706519
Premature ovarian failure (POF) GAD: 18630123
Premature ovarian failure (POF) GAD: 18630123
Varicocele GAD: 19151739
Preterm birth risk GAD: 11520401
Endometriosis INFBASE: 26350109
Endometriosis INFBASE: 10764452
Oocyte quality INFBASE: 17919612
Polycystic ovaries (PCO) INFBASE: 15333250
Azoospermia MIK: 23450492
Male factor infertility MIK: 23450492
Azoospermia MIK: 17569254
Oligozoospermia MIK: 25532576
Male factor infertility MIK: 20686491
Male factor infertility MIK: 21561808
Spermatogenesis defects MIK: 23311983
Female infertility INFBASE: 15333250
Infertility INFBASE: 19768671
Chronic obstructive pulmonary disease (COPD) GAD: 18461673
Lung disease GAD: 12153964
Pulmonary fibrosis GAD: 15923250
Rhinitis GAD: 20088379
Erythema GAD: 12083949
Solar keratosis GAD: 12485442
Vitiligo GAD: 19571817
Dermatitis GAD: 19842992
Connective tissue diseases GAD: 19527514
Ascorbic acid deficiency GAD: 19710200
Chronic toxic encephalopathy GAD: 14992466
Dysmenorrhea GAD: 20197727
Elers-Danlose syndrome GAD: 17020091
Emphysema GAD: 12579334
Encephalopathy GAD: 17022435
Respiratory distress syndrome GAD: 18993042
Non-allergic nasal polyposis GAD: 19701760
Isolated orofacial clefts KEGG: H00516
Genital diseases GAD: 19799358
Proteinuria GAD: 18455004
Nephrotic syndrome GAD: 18594869
Balkan nephropathy GAD: 15365959
Cataract GAD: 20120433
Azoospermia MIK: 23450492
Oligospermia MIK: 25532576
Spermatogenic defects MIK: 23311983
Male infertility MIK: 21561808
Teratozoospermia MIK: 17327269
Varicocele MIK: 18163994

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
25532576 Idiopathic
azoosperm
ia, oligos
permia
 GSTT1-null and GSTP1 (Ile/Val + Val/Val), GSTP1 variant genotype (Ile/Val + Val/Val) Chinese
 723 (361 men wi
th idiopathic a
zoospermia, 118
men with idiop
athic oligosper
mia, 234 age-ma
tched healthy f
ertile male con
trols)
 Male infertility GSTM1
GSTT1
and GSTP1
 Show abstract
23877133 Male infer
tility
 Asian a
nd Cauc
asian 
 120 (60 with pr
imary idiopathi
c infertility,
60 fertile men
as controls)
 Male infertility GSTM1
GSTT1
 Show abstract
23631429 Male infer
tility
 Caucasi
an and
Chinese
 4035 (2174 case
s, 1861 control
s)
 Male infertility GSTM1
GSTT1
 Show abstract
23450492 Azoospermi
a
 M1 (-/-) and P1 (Ile/Val or Val/Val) genotype
378 (236 azoosp
ermia patients,
142 healthy fe
rtile male cont
rols)
 Male infertility GSTT1
 GSTM1 and GSTP1
 Show abstract
23311983 Male facto
r infertil
ity, Impai
red sperma
togenesis
 Chinese
 554 (353 patien
ts with azoospe
rmia or oligosp
ermia, 201 fert
ile controls)
 Male infertility
Show abstract
23239128 Male facto
r infertil
ity
 Asian,
Caucasi
an
Male infertility GSTM1
GSTT1
 Show abstract
23164539 Male facto
r infertil
ity

Male infertility GSTM1
GSTT1
 Show abstract
23026209 Idiopathic
male infe
rtility
 Asian,
Europea
n
 3682 (1897 case
s, 1785 control
s)
 Male infertility GSTM1
GSTT1
 Show abstract
22903474 Male facto
r infertil
ity
 GSTP1 Ile/Val genotype
2377 (1323 case
s, 1054 control
s)
 Male infertility GSTM1
GSTT1
and GSTP1
 Show abstract
22383780 Male infer
tility
 GSTM1 and GSTT1 (-/-) genotypes North I
ndian
 204 (113 nonobs
tructive azoosp
ermia patients,
91 healthy fer
tile controls)
 Male infertility GSTT1
GSTM1
 Show abstract
21775774 Idiopathic
male infe
rtility
 Norther
n Iran
 350 (150 infert
ile men, 200 he
althy men as co
ntrols)
 Male infertility GSTT1
GSTM1
and CYP1A1
 Show abstract
21561808 Male infer
tility
 PON1-55/192, PON2-311, GSTM1/T1
381 (187 infert
ile men (86 wit
h non-obstructi
ve azoospermia
(NOA) and 101 w
ith oligoasthen
oteratozoosperm
ia (OAT)), 194
fertile men)
 Male infertility PON1
PON2
GSTM1
GSTT1
 Show abstract
21546615 Varicocele
, Male inf
ertility
 GSTP1 A/A and A/G+G/G genotypes, GSTT1 null genotypes Northwe
stern C
hina
 95 (65 infertil
e men with vari
coceles, 30 con
trols)
 Male infertility GSTM1
GSTT1
and GSTM1/T1
 Show abstract
20686491 Idiopathic
male infe
rtility
 GSTM1 present/null, GSTT1 present/ null, GSTP1 Ile105Val
1617 (862 male
infertility cas
es, 755 contro
ls)
 Male infertility GSTM1
GSTT1
GSTP1
Show abstract
20505681 Idiopathic
male infe
rtility
 GSTP1 (Ile/Val and Val/Val), GSTM1 or GSTT1null genotypes
332 (166 men su
ffering from id
iopathic oligoa
sthenoteratozoo
spermia (OAT),
166 healthy mal
e controls)
 Male infertility GSTM1
GSTT1 and GSTP1
 Show abstract
19768671 Idiopathic
infertili
ty
 GSTM1/T1 (null)
466 (233 men wi
th idiopathic i
nfertility, 105
normal individ
uals, 128 abnor
mal individuals
)
 Male infertility GSTM1
GSTT1
 Show abstract
18774560 Male facto
r infertil
ity
 CYP1A1 Val/Val or CYP1A1 Ile/Val, GSTM null genotype
215 (110 men wi
th infertility,
105 healthy fe
rtile men)
 Male infertility CYP1A1(*)2C
 GSTM1
and GSTT1
 Show abstract
20056207 Idiopathic
infertili
ty
 Russian
 430 (203 infert
ile, 227 fertil
e men)
 Male infertility GSTM1
GSTT1
 Show abstract
19151739 Varicocele
, Male inf
ertility
375 (72 inferti
le varicocele p
atients, 202 in
fertile patient
s without varic
ocele, 101 male
control)
 Male infertility
Show abstract
18163994 Varicocele
 Chinese
 117 (63 inferti
le patients wit
h varicocele, 5
4 healthy ferti
le controls)
 Male infertility
Show abstract
18097510 Idiopathic
 azoosperm
ia or olig
ospermia
 Chinese
 337 (78 patient
s with idiopath
ic azoospermia,
103 patients w
ith idiopathic
oligospermia, 1
56 age-matched
controls)
 Male infertility
Show abstract
17569254 Idiopathic
 azoosperm
ia and oli
gospermia
127 (34 patient
s with idiopath
ic azoospermia,
40 patients wi
th idiopathic o
ligospermia, 53
healthy contro
ls with normal
sperm concentra
tion and motili
ty)
 Male infertility
Show abstract
23238917 Idiopathic
infertili
ty
3574 (1,845 idi
opathic inferti
lity males, 1,7
29 controls)
 Male infertility GSTM1
GSTT1
 Show abstract
18774560 Male facto
r infertil
ity
215 (110 men wi
th infertility,
105 healthy fe
rtile men)
 Male infertility
Show abstract
25677140 Varicocele

Male infertility
Show abstract
30732132 Male infer
tility
 Chinese
 4909(3048 cases
, 1861 controls
)
 Male infertility GSTM1
 Show abstract
28944422 Male infer
tility

Male infertility
Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
29376593 Male infer
tility
264 (160 infert
ile Russian men
of reproductiv
e age, 104 heal
thy Russian vol
unteers)
 Male infertility
Show abstract