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Gene id |
2947 |
| Gene Summary SNPs KEGG pathways Diseases PubMed |
Gene Summary
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Gene Symbol |
GSTM3 Gene UCSC Ensembl |
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Aliases |
GST5, GSTB, GSTM3-3, GTM3 |
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Gene name |
glutathione S-transferase mu 3 |
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Alternate names |
glutathione S-transferase Mu 3, GST class-mu 3, S-(hydroxyalkyl)glutathione lyase M3, brain GST, brain type mu-glutathione S-transferase, epididymis secretory sperm binding protein, glutathione S-alkyltransferase M3, glutathione S-aralkyltransferase M3, glutathio, |
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Gene location |
1p13.3 (109741037: 109733931) Exons: 9 NC_000003.12
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Gene summary(Entrez) |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg
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OMIM |
138390 |
SNPs |
rs3814309
Strand: Allele origin: Allele change: Mutation type: snv
NC_000001.11 g.109734781T>C
NC_000001.10 g.110277403T>C
NM_000849.4 c.*2290A>G
NM_000849.5 c.*2290A>G
NR_024537.1 n.3202A>G|SEQ=[T/C]|GENE=GSTM3
rs1571858
Strand: Allele origin: Allele change: Mutation type: snv
NC_000001.11 g.109737292C>A
NC_000001.11 g.109737292C>G
NC_000001.11 g.109737292C>T
NC_000001.10 g.110279914C>A
NC_000001.10 g.110279914C>G
NC_000001.10 g.110279914C>T|SEQ=[C/A/G/T]|GENE=GSTM3
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| Associated diseases |
References |
| Cancer (oral) | GAD: 12016153 |
| Cancer (stomach) | GAD: 11692073 |
| Cancer (skin) | GAD: 17083362 |
| Cancer (lung) | GAD: 11740339 |
| Cancer (gall bladder) | GAD: 16760134 |
| Cancer (gastric) | GAD: 19521675 |
| Glioma | GAD: 20391338 |
| Head and neck cancer | GAD: 12548461 |
| Cancer (ovarian) | GAD: 19786980 |
| Cancer (prostate) | GAD: 19223546 |
| Cancer (esophageal) | GAD: 20661821 |
| Cancer (bladder) | GAD: 11173863 |
| Cancer (brain) | GAD: 17372252 |
| Cancer (breast) | GAD: 11303592 |
| Cancer (kidney) | GAD: 17617661 |
| Cancer (Laryngeal) | GAD: 12359356 |
| Colorectal cancer | GAD: 11408349 |
| Atherosclerosis | GAD: 20485444 |
| Hypertension | GAD: 18551009 |
| Cystic fibrosis | GAD: 15115915 |
| Cleft defects | GAD: 20634891 |
| Glaucoma | GAD: 11040079 |
| Eye diseases | GAD: 18447907 |
| Asthma | GAD: 11927838 |
| Alzheimer's disease | GAD: 17904251 |
| Parkinson disease | GAD: 17034008 |
| Mental retardation | GAD: 19860743 |
| Non-Hodgkin lymphoma | GAD: 19822571 |
| Prostatic hyperplasia | GAD: 19407363 |
| Non obstructive azoospermia | MIK: 29528137 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Nonobstructive azoospermia | MIK: 29528137 |
| Teratozoospermia | MIK: 17327269 |
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|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29528137 |
Nonobstruc
tive azoos
permia
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|
|
21 (14 nonobstr
uctive azoosper
mic men (N = 4;
normal FSH and
normal testicu
lar volume and
N = 10; high FS
H and small tes
ticular volume)
, seven normozo
ospermic men)
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
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|
|
13 (5 controls,
8 cases)
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Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
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|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
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|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|