• Gene id: 2913

Gene Summary

• Gene Symbol: GRM3   Gene   UCSC   Ensembl
• Aliases: GLUR3, GPRC1C, MGLUR3, mGlu3
• Gene name: glutamate metabotropic receptor 3
• Alternate names: metabotropic glutamate receptor 3, glutamate receptor, metabotropic 3,
• Gene location: 7q21.11-q21.12 (109426447: 109399041)     Exons: 9     NC_000001.11
• Gene summary(Entrez): L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe
• OMIM: 601115

Protein Summary

• Protein general information: Q14832  
  • Name: Metabotropic glutamate receptor 3 (mGluR3)
  • Length: 879  
  • Mass: 98879
  • Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. {ECO
• Sequence:

  MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFA
  IDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSY
  SSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGET
  GIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
  DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDK
  HLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDA
  DSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGD
  VCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
  HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKN
  GAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVIL
  CTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHI
  ILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL

• Structural information:
  • Interpro: IPR001828  IPR000337  IPR011500  IPR038550  IPR017978   IPR017979  IPR000162  IPR001234  IPR028082  
  • Prosite: PS00979 PS00980 PS00981 PS50259
  • PDB: 1S8M 3SM9 4XAR 5CNK 5CNM 6B7H
  • PDBsum: 1S8M 3SM9 4XAR 5CNK 5CNM 6B7H
  • STRING: ENSP00000355316
• Other Databases: GeneCards:  GRM3  Malacards:  GRM3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0097110	scaffold protein binding	ISS	molecular function
GO:0030424	axon	ISS	cellular component
GO:0097449	astrocyte projection	ISS	cellular component
GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	biological process
GO:0008066	glutamate receptor activity	IBA	molecular function
GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0001641	group II metabotropic glutamate receptor activity	IBA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007194	negative regulation of adenylate cyclase activity	TAS	biological process
GO:0007268	chemical synaptic transmission	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005246	calcium channel regulator activity	IEA	molecular function
GO:0030424	axon	IEA	cellular component
GO:0042734	presynaptic membrane	IEA	cellular component
GO:0043005	neuron projection	IEA	cellular component
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0099055	integral component of postsynaptic membrane	IEA	cellular component
GO:0001641	group II metabotropic glutamate receptor activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0014069	postsynaptic density	IEA	cellular component
GO:0043197	dendritic spine	IEA	cellular component
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0099056	integral component of presynaptic membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0008066	glutamate receptor activity	TAS	molecular function
GO:0004930	G protein-coupled receptor activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04072	Phospholipase D signaling pathway
hsa04724	Glutamatergic synapse
hsa05030	Cocaine addiction

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)