• Gene id: 29121

Gene Summary

• Gene Symbol: CLEC2D   Gene   UCSC   Ensembl
• Aliases: CLAX, LLT1, OCIL
• Gene name: C-type lectin domain family 2 member D
• Alternate names: C-type lectin domain family 2 member D, C-type lectin related f, C-type lectin superfamily 2, member D, LLT-1, lectin-like NK cell receptor, lectin-like transcript 1, osteoclast inhibitory lectin,
• Gene location: 12p13.31 (7751599: 7729244)     Exons: 8     NC_000012.12
• Gene summary(Entrez): This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several
• OMIM: 605659

Protein Summary

• Protein general information: Q9UHP7  
  • Name: C type lectin domain family 2 member D (Lectin like NK cell receptor) (Lectin like transcript 1) (LLT 1) (Osteoclast inhibitory lectin)
  • Length: 191  
  • Mass: 21849
  • Tissue specificity: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and
• Sequence:

  MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWRLFFLIMFLTIIVCGMVAALSAIRANCHQEPSVCLQAAC
  PESWIGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQELNFLLRYKGPSDHWIGLSREQGQPWKWINGTE
  WTRQFPILGAGECAYLNDKGASSARHYTERKWICSKSDIHV

• Structural information:
  • Protein Domains: (82..18-)
    (/note="C-type-lectin)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00040"-)
  • Interpro: IPR001304  IPR016186  IPR016187  IPR033992  
  • Prosite: PS50041
  • CDD: cd03593
  • PDB: 4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
  • PDBsum: 4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
  • STRING: ENSP00000261340
• Other Databases: GeneCards:  CLEC2D  Malacards:  CLEC2D

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009897	external side of plasma membrane	IBA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0004888	transmembrane signaling receptor activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0016020	membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0050776	regulation of immune response	TAS	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)