• Gene id: 2912

Gene Summary

• Gene Symbol: GRM2   Gene   UCSC   Ensembl
• Aliases: GLUR2, GPRC1B, MGLUR2, mGlu2
• Gene name: glutamate metabotropic receptor 2
• Alternate names: metabotropic glutamate receptor 2, glutamate receptor homolog, glutamate receptor, metabotropic 2,
• Gene location: 3p21.2 (51707067: 51718615)     Exons: 8     NC_000003.12
• Gene summary(Entrez): L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe
• OMIM: 607181

SNPs

rs2656927

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000019.10   g.4908263C>T
NC_000019.9   g.4908275C>T
NG_033256.2   g.10184C>T|SEQ=[C/T]|GENE=UHRF1
ARRDC5   645432

rs8103849

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000019.10   g.4909617C>G
NC_000019.9   g.4909629C>G
NG_033256.2   g.11538C>G
NM_001048201.3   c.-49C>G
NM_001048201.2   c.-49C>G
NM_001048201.1   c.-49C>G
XM_011527942.2   c.-49C>G|SEQ=[C/G]|GENE=UHRF1
ARRDC5   645432

Protein Summary

• Protein general information: Q14416  
  • Name: Metabotropic glutamate receptor 2 (mGluR2)
  • Length: 872  
  • Mass: 95568
  • Tissue specificity: Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO
• Sequence:

  MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRD
  PHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQ
  VANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFE
  LEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
  ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQE
  SKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGI
  GRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPC
  QPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
  SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFIS
  PASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTR
  KCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNV
  VSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL

• Structural information:
  • Interpro: IPR001828  IPR000337  IPR011500  IPR038550  IPR017978   IPR017979  IPR000162  IPR001458  IPR028082  
  • Prosite: PS00979 PS00980 PS00981 PS50259
  • PDB: 4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
  • PDBsum: 4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
  • DIP: 59826
  • STRING: ENSP00000378492
• Other Databases: GeneCards:  GRM2  Malacards:  GRM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0097110	scaffold protein binding	ISS	molecular function
GO:0030424	axon	ISS	cellular component
GO:0097449	astrocyte projection	ISS	cellular component
GO:0051896	regulation of protein kinase B signaling	ISS	biological process
GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	biological process
GO:0008066	glutamate receptor activity	IBA	molecular function
GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0001641	group II metabotropic glutamate receptor activity	IBA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007194	negative regulation of adenylate cyclase activity	TAS	biological process
GO:0007268	chemical synaptic transmission	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0090461	glutamate homeostasis	IEA	biological process
GO:0001641	group II metabotropic glutamate receptor activity	IEA	molecular function
GO:0097449	astrocyte projection	IEA	cellular component
GO:0097110	scaffold protein binding	IEA	molecular function
GO:0051896	regulation of protein kinase B signaling	IEA	biological process
GO:0001641	group II metabotropic glutamate receptor activity	IEA	molecular function
GO:0043005	neuron projection	IEA	cellular component
GO:0007268	chemical synaptic transmission	IEA	biological process
GO:0005246	calcium channel regulator activity	IEA	molecular function
GO:0099055	integral component of postsynaptic membrane	IEA	cellular component
GO:0042734	presynaptic membrane	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0014047	glutamate secretion	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0008066	glutamate receptor activity	TAS	molecular function
GO:0004930	G protein-coupled receptor activity	TAS	molecular function
GO:0097110	scaffold protein binding	ISS	molecular function
GO:0030424	axon	ISS	cellular component
GO:0097449	astrocyte projection	ISS	cellular component
GO:0051896	regulation of protein kinase B signaling	ISS	biological process
GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	biological process
GO:0008066	glutamate receptor activity	IBA	molecular function
GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0001641	group II metabotropic glutamate receptor activity	IBA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007194	negative regulation of adenylate cyclase activity	TAS	biological process
GO:0007268	chemical synaptic transmission	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0090461	glutamate homeostasis	IEA	biological process
GO:0001641	group II metabotropic glutamate receptor activity	IEA	molecular function
GO:0097449	astrocyte projection	IEA	cellular component
GO:0097110	scaffold protein binding	IEA	molecular function
GO:0051896	regulation of protein kinase B signaling	IEA	biological process
GO:0001641	group II metabotropic glutamate receptor activity	IEA	molecular function
GO:0043005	neuron projection	IEA	cellular component
GO:0007268	chemical synaptic transmission	IEA	biological process
GO:0005246	calcium channel regulator activity	IEA	molecular function
GO:0099055	integral component of postsynaptic membrane	IEA	cellular component
GO:0042734	presynaptic membrane	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0014047	glutamate secretion	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA	biological process
GO:0008066	glutamate receptor activity	TAS	molecular function
GO:0004930	G protein-coupled receptor activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04072	Phospholipase D signaling pathway
hsa04724	Glutamatergic synapse
hsa05030	Cocaine addiction

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq