• Gene id: 29101

Gene Summary

• Gene Symbol: SSU72   Gene   UCSC   Ensembl
• Aliases: HSPC182, PNAS-120
• Gene name: SSU72 homolog, RNA polymerase II CTD phosphatase
• Alternate names: RNA polymerase II subunit A C-terminal domain phosphatase SSU72, CTD phosphatase SSU72,
• Gene location: 1p36.33 (1574862: 1541672)     Exons: 5     NC_000001.11
• OMIM: 617680

Protein Summary

• Protein general information: Q9NP77  
  • Name: RNA polymerase II subunit A C terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)
  • Length: 194  
  • Mass: 22574
• Sequence:

  MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKEL
  YTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATL
  GAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY

• Structural information:
  • Interpro: IPR006811  
  • PDB: 3O2Q 3O2S 4H3H 4H3K
  • PDBsum: 3O2Q 3O2S 4H3H 4H3K
  • DIP: 53666
  • STRING: ENSP00000291386
• Other Databases: GeneCards:  SSU72  Malacards:  SSU72

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA	molecular function
GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain	IBA	biological process
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	IBA	cellular component
GO:0006369	termination of RNA polymerase II transcription	IBA	biological process
GO:0006378	mRNA polyadenylation	IBA	biological process
GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain	IDA	biological process
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006378	mRNA polyadenylation	IMP	biological process
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0006397	mRNA processing	IEA	biological process
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0006397	mRNA processing	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03015	mRNA surveillance pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq