• Gene id: 28987

Gene Summary

• Gene Symbol: NOB1   Gene   UCSC   Ensembl
• Aliases: ART-4, MST158, MSTP158, NOB1P, PSMD8BP1
• Gene name: NIN1 (RPN12) binding protein 1 homolog
• Alternate names: RNA-binding protein NOB1, NIN1/PSMD8 binding protein 1 homolog, PSMD8 binding protein 1, adenocarcinoma antigen recognized by T lymphocytes 4, nin one binding protein, phosphorylation regulatory protein HP-10, protein ART-4,
• Gene location: 16q22.1 (69754967: 69741853)     Exons: 17     NC_000016.10
• Gene summary(Entrez): In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, a
• OMIM: 613586

Protein Summary

• Protein general information: Q9ULX3  
  • Name: RNA binding protein NOB1 (EC 3.1. . ) (Phosphorylation regulatory protein HP 10) (Protein ART 4)
  • Length: 412  
  • Mass: 46675
  • Tissue specificity: Detected in liver, lung, placenta, endothelial cells and spleen. {ECO
• Sequence:

  MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFSKKTGD
  YPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPE
  NLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCD
  VPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTV
  SDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVE
  NDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR

• Structural information:
  • Protein Domains: (5..10-)
    (/note="PINc-)
    (/evidence="ECO:0000255"-)
  • Interpro: IPR039907  IPR017117  IPR036283  IPR014881  IPR002716   IPR033411  IPR033461  
  • PDB: 6G18 6G4S 6G51 6G53 6G5I
  • PDBsum: 6G18 6G4S 6G51 6G53 6G5I
  • STRING: ENSP00000268802
• Other Databases: GeneCards:  NOB1  Malacards:  NOB1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004521	endoribonuclease activity	IBA	molecular function
GO:0030688	preribosome, small subunit precursor	IBA	cellular component
GO:0030490	maturation of SSU-rRNA	IBA	biological process
GO:0004521	endoribonuclease activity	IEA	molecular function
GO:0042274	ribosomal small subunit biogenesis	IEA	biological process
GO:0000469	cleavage involved in rRNA processing	IEA	biological process
GO:0004519	endonuclease activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0004521	endoribonuclease activity	EXP	molecular function
GO:0004521	endoribonuclease activity	EXP	molecular function
GO:0006364	rRNA processing	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007601	visual perception	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa03008	Ribosome biogenesis in eukaryotes

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq