• Gene id: 28970

Gene Summary

• Gene Symbol: C11orf54   Gene   UCSC   Ensembl
• Aliases: PTD012, PTOD012
• Gene name: chromosome 11 open reading frame 54
• Alternate names: ester hydrolase C11orf54, epididymis secretory sperm binding protein,
• Gene location: 11q21 (93741593: 93764748)     Exons: 13     NC_000011.10
• OMIM: 615810

Protein Summary

• Protein general information: Q9H0W9  
  • Name: Ester hydrolase C11orf54 (EC 3.1. . )
  • Length: 315  
  • Mass: 35117
• Sequence:

  MACAEFSFHVPSLEELAGVMQKGLKDNFADVQVSVVDCPDLTKEPFTFPVKGICGKTRIAEVGGVPYLLPLVNQK
  KVYDLNKIAKEIKLPGAFILGAGAGPFQTLGFNSEFMPVIQTESEHKPPVNGSYFAHVNPADGGCLLEKYSEKCH
  DFQCALLANLFASEGQPGKVIEVKAKRRTGPLNFVTCMRETLEKHYGNKPIGMGGTFIIQKGKVKSHIMPAEFSS
  CPLNSDEEVNKWLHFYEMKAPLVCLPVFVSRDPGFDLRLEHTHFFSRHGEGGHYHYDTTPDIVEYLGYFLPAEFL
  YRIDQPKETHSIGRD

• Structural information:
  • Interpro: IPR015021  
  • PDB: 1XCR
  • PDBsum: 1XCR
  • STRING: ENSP00000331209
• Other Databases: GeneCards:  C11orf54  Malacards:  C11orf54

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0008270	zinc ion binding	IBA	molecular function
GO:0016788	hydrolase activity, acting on ester bonds	IBA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0016788	hydrolase activity, acting on ester bonds	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881