• Gene id: 28966

Gene Summary

• Gene Symbol: SNX24   Gene   UCSC   Ensembl
• Aliases: PRO1284, SBBI31
• Gene name: sorting nexin 24
• Alternate names: sorting nexin-24, sorting nexing 24,
• Gene location: 5q23.2 (122845448: 123029317)     Exons: 13     NC_000005.10

Protein Summary

• Protein general information: Q9Y343  
  • Name: Sorting nexin 24
  • Length: 169  
  • Mass: 19818
• Sequence:

  MEVYIPSFRYEESDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRR
  QGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEESSKLSHQPVLLFLRDPYVLPAASDFP
  NVVIEGVLHGIFYPHLQPR

• Structural information:
  • Protein Domains: (1..12-)
    (/note="PX-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00147"-)
  • Interpro: IPR001683  IPR036871  
  • Prosite: PS50195
  • PDB: 4AZ9
  • PDBsum: 4AZ9
  • STRING: ENSP00000261369
• Other Databases: GeneCards:  SNX24  Malacards:  SNX24

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0008289	lipid binding	IEA	molecular function
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0010314	phosphatidylinositol-5-phosphate binding	IEA	molecular function
GO:0070273	phosphatidylinositol-4-phosphate binding	IEA	molecular function
GO:0032266	phosphatidylinositol-3-phosphate binding	IEA	molecular function
GO:0030659	cytoplasmic vesicle membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq