|
Gene id |
2880 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
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|
Gene Symbol |
GPX5 Gene UCSC Ensembl |
|
Aliases |
EGLP, GPx-5, GSHPx-5, HEL-S-75p |
|
Gene name |
glutathione peroxidase 5 |
|
Alternate names |
epididymal secretory glutathione peroxidase, epididymal androgen-related protein, epididymis secretory sperm binding protein Li 75p, epididymis-specific glutathione peroxidase-like protein, |
|
Gene location |
6p22.1 (28526011: 28534950) Exons: 6 NC_000004.12
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|
Gene summary(Entrez) |
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a se
|
|
OMIM |
603435 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
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| Associated diseases |
References |
| Cancer (lung) | GAD: 20200426 |
| Plays a crucial role in speramtogenesis | MIK: 9110319 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
| Unexplained infertility | MIK: 25753583 |
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|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 9110319 |
Plays an i
mportant r
ole in spe
rm maturat
ion
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
| 25753583 |
Unexplaine
d infertil
ity
|
|
|
46 (17 fertile
men, 29 male pa
tients)
|
Male infertility |
Microarray
|
Show abstract |
|