• Gene id: 286319

Gene Summary

• Gene Symbol: TUSC1   Gene   UCSC   Ensembl
• Aliases: CCDC89B, TSG-9, TSG9
• Gene name: tumor suppressor candidate 1
• Alternate names: tumor suppressor candidate gene 1 protein,
• Gene location: 9p21.2 (25678857: 25676388)     Exons: 1     NC_000001.11
• Gene summary(Entrez): This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it
• OMIM: 610529

SNPs

rs12348

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000009.12   g.25677217T>C
NC_000009.12   g.25677217T>G
NC_000009.11   g.25677215T>C
NC_000009.11   g.25677215T>G
NG_012031.1   g.6642A>G
NG_012031.1   g.6642A>C
NM_001004125.2   c.*466A>G
NM_001004125.2   c.*466A>C|SEQ=[T/C/G]|GENE=TUSC1

Diseases

Associated diseases	References
Melanoma	GAD: 20574843
Cancer (gall bladder)	GAD: 22318345
Carotid artery diseases	GAD: 17903303
Male factor infertility	MIK: 28975488
Male infertility	MIK: 28975488
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28975488	Male infertility				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)